An NOS3 Haplotype Is Protective against Hypertension in a Caucasian Population
The endothelial nitric oxide synthase gene (NOS3) has been implicated in the development of hypertension, although the specific role of variants and haplotypes has not been clarified. In this study, the association of three polymorphisms (promoter T786C, intronic 4a/b, and nonsynonymous G894T) was t...
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| Format: | Article |
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Wiley
2010-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2010/865031 |
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| author | Georgios D. Kitsios Elias Zintzaras |
| author_facet | Georgios D. Kitsios Elias Zintzaras |
| author_sort | Georgios D. Kitsios |
| collection | DOAJ |
| description | The endothelial nitric oxide synthase gene (NOS3) has been implicated in the development of hypertension, although the specific role of variants and haplotypes has not been clarified. In this study, the association of three polymorphisms (promoter T786C, intronic 4a/b, and nonsynonymous G894T) was tested in a case-control sample of 230 patients with essential hypertension and 306 healthy controls. Haplotype analysis was also performed. The mutant allele a∗ of the 4a/b polymorphism showed a protective effect against hypertension under a dominant model (odds ratio=0.64, 95% confidence interval (0.44–0.93)), although this effect was not significant after the adjustment for covariates (𝑃=0.06). The estimated frequency of the haplotype composed of the T786∗, 4a∗, and G894∗ alleles was significantly higher in controls (5.5%) compared to cases (2%). These results indicate that although individual NOS3 polymorphisms are not associated with hypertension, a rare haplotype of the gene might be protective against the development of hypertension. |
| format | Article |
| id | doaj-art-7833116fc2e14d129360f0e9c9e8f75c |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-7833116fc2e14d129360f0e9c9e8f75c2025-08-20T03:35:12ZengWileyInternational Journal of Hypertension2090-03922010-01-01201010.4061/2010/865031865031An NOS3 Haplotype Is Protective against Hypertension in a Caucasian PopulationGeorgios D. Kitsios0Elias Zintzaras1Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Tufts MC no. 63, Boston, MA 02111, USAInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Tufts MC no. 63, Boston, MA 02111, USAThe endothelial nitric oxide synthase gene (NOS3) has been implicated in the development of hypertension, although the specific role of variants and haplotypes has not been clarified. In this study, the association of three polymorphisms (promoter T786C, intronic 4a/b, and nonsynonymous G894T) was tested in a case-control sample of 230 patients with essential hypertension and 306 healthy controls. Haplotype analysis was also performed. The mutant allele a∗ of the 4a/b polymorphism showed a protective effect against hypertension under a dominant model (odds ratio=0.64, 95% confidence interval (0.44–0.93)), although this effect was not significant after the adjustment for covariates (𝑃=0.06). The estimated frequency of the haplotype composed of the T786∗, 4a∗, and G894∗ alleles was significantly higher in controls (5.5%) compared to cases (2%). These results indicate that although individual NOS3 polymorphisms are not associated with hypertension, a rare haplotype of the gene might be protective against the development of hypertension.http://dx.doi.org/10.4061/2010/865031 |
| spellingShingle | Georgios D. Kitsios Elias Zintzaras An NOS3 Haplotype Is Protective against Hypertension in a Caucasian Population International Journal of Hypertension |
| title | An NOS3 Haplotype Is Protective against Hypertension in a Caucasian Population |
| title_full | An NOS3 Haplotype Is Protective against Hypertension in a Caucasian Population |
| title_fullStr | An NOS3 Haplotype Is Protective against Hypertension in a Caucasian Population |
| title_full_unstemmed | An NOS3 Haplotype Is Protective against Hypertension in a Caucasian Population |
| title_short | An NOS3 Haplotype Is Protective against Hypertension in a Caucasian Population |
| title_sort | nos3 haplotype is protective against hypertension in a caucasian population |
| url | http://dx.doi.org/10.4061/2010/865031 |
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