Turbulent Kinetic Energy Measurement Using Phase Contrast MRI for Estimating the Post-Stenotic Pressure Drop: In Vitro Validation and Clinical Application.
<h4>Background</h4>Although the measurement of turbulence kinetic energy (TKE) by using magnetic resonance imaging (MRI) has been introduced as an alternative index for quantifying energy loss through the cardiac valve, experimental verification and clinical application of this parameter...
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0151540&type=printable |
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| author | Hojin Ha Guk Bae Kim Jihoon Kweon Hyung Kyu Huh Sang Joon Lee Hyun Jung Koo Joon-Won Kang Tae-Hwan Lim Dae-Hee Kim Young-Hak Kim Namkug Kim Dong Hyun Yang |
| author_facet | Hojin Ha Guk Bae Kim Jihoon Kweon Hyung Kyu Huh Sang Joon Lee Hyun Jung Koo Joon-Won Kang Tae-Hwan Lim Dae-Hee Kim Young-Hak Kim Namkug Kim Dong Hyun Yang |
| author_sort | Hojin Ha |
| collection | DOAJ |
| description | <h4>Background</h4>Although the measurement of turbulence kinetic energy (TKE) by using magnetic resonance imaging (MRI) has been introduced as an alternative index for quantifying energy loss through the cardiac valve, experimental verification and clinical application of this parameter are still required.<h4>Objectives</h4>The goal of this study is to verify MRI measurements of TKE by using a phantom stenosis with particle image velocimetry (PIV) as the reference standard. In addition, the feasibility of measuring TKE with MRI is explored.<h4>Methods</h4>MRI measurements of TKE through a phantom stenosis was performed by using clinical 3T MRI scanner. The MRI measurements were verified experimentally by using PIV as the reference standard. In vivo application of MRI-driven TKE was explored in seven patients with aortic valve disease and one healthy volunteer. Transvalvular gradients measured by MRI and echocardiography were compared.<h4>Results</h4>MRI and PIV measurements of TKE are consistent for turbulent flow (0.666 < R2 < 0.738) with a mean difference of -11.13 J/m3 (SD = 4.34 J/m3). Results of MRI and PIV measurements differ by 2.76 ± 0.82 cm/s (velocity) and -11.13 ± 4.34 J/m3 (TKE) for turbulent flow (Re > 400). The turbulence pressure drop correlates strongly with total TKE (R2 = 0.986). However, in vivo measurements of TKE are not consistent with the transvalvular pressure gradient estimated by echocardiography.<h4>Conclusions</h4>These results suggest that TKE measurement via MRI may provide a potential benefit as an energy-loss index to characterize blood flow through the aortic valve. However, further clinical studies are necessary to reach definitive conclusions regarding this technique. |
| format | Article |
| id | doaj-art-783001f2580c4ebd8079193fe2abe0c8 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-783001f2580c4ebd8079193fe2abe0c82025-08-20T03:11:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e015154010.1371/journal.pone.0151540Turbulent Kinetic Energy Measurement Using Phase Contrast MRI for Estimating the Post-Stenotic Pressure Drop: In Vitro Validation and Clinical Application.Hojin HaGuk Bae KimJihoon KweonHyung Kyu HuhSang Joon LeeHyun Jung KooJoon-Won KangTae-Hwan LimDae-Hee KimYoung-Hak KimNamkug KimDong Hyun Yang<h4>Background</h4>Although the measurement of turbulence kinetic energy (TKE) by using magnetic resonance imaging (MRI) has been introduced as an alternative index for quantifying energy loss through the cardiac valve, experimental verification and clinical application of this parameter are still required.<h4>Objectives</h4>The goal of this study is to verify MRI measurements of TKE by using a phantom stenosis with particle image velocimetry (PIV) as the reference standard. In addition, the feasibility of measuring TKE with MRI is explored.<h4>Methods</h4>MRI measurements of TKE through a phantom stenosis was performed by using clinical 3T MRI scanner. The MRI measurements were verified experimentally by using PIV as the reference standard. In vivo application of MRI-driven TKE was explored in seven patients with aortic valve disease and one healthy volunteer. Transvalvular gradients measured by MRI and echocardiography were compared.<h4>Results</h4>MRI and PIV measurements of TKE are consistent for turbulent flow (0.666 < R2 < 0.738) with a mean difference of -11.13 J/m3 (SD = 4.34 J/m3). Results of MRI and PIV measurements differ by 2.76 ± 0.82 cm/s (velocity) and -11.13 ± 4.34 J/m3 (TKE) for turbulent flow (Re > 400). The turbulence pressure drop correlates strongly with total TKE (R2 = 0.986). However, in vivo measurements of TKE are not consistent with the transvalvular pressure gradient estimated by echocardiography.<h4>Conclusions</h4>These results suggest that TKE measurement via MRI may provide a potential benefit as an energy-loss index to characterize blood flow through the aortic valve. However, further clinical studies are necessary to reach definitive conclusions regarding this technique.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0151540&type=printable |
| spellingShingle | Hojin Ha Guk Bae Kim Jihoon Kweon Hyung Kyu Huh Sang Joon Lee Hyun Jung Koo Joon-Won Kang Tae-Hwan Lim Dae-Hee Kim Young-Hak Kim Namkug Kim Dong Hyun Yang Turbulent Kinetic Energy Measurement Using Phase Contrast MRI for Estimating the Post-Stenotic Pressure Drop: In Vitro Validation and Clinical Application. PLoS ONE |
| title | Turbulent Kinetic Energy Measurement Using Phase Contrast MRI for Estimating the Post-Stenotic Pressure Drop: In Vitro Validation and Clinical Application. |
| title_full | Turbulent Kinetic Energy Measurement Using Phase Contrast MRI for Estimating the Post-Stenotic Pressure Drop: In Vitro Validation and Clinical Application. |
| title_fullStr | Turbulent Kinetic Energy Measurement Using Phase Contrast MRI for Estimating the Post-Stenotic Pressure Drop: In Vitro Validation and Clinical Application. |
| title_full_unstemmed | Turbulent Kinetic Energy Measurement Using Phase Contrast MRI for Estimating the Post-Stenotic Pressure Drop: In Vitro Validation and Clinical Application. |
| title_short | Turbulent Kinetic Energy Measurement Using Phase Contrast MRI for Estimating the Post-Stenotic Pressure Drop: In Vitro Validation and Clinical Application. |
| title_sort | turbulent kinetic energy measurement using phase contrast mri for estimating the post stenotic pressure drop in vitro validation and clinical application |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0151540&type=printable |
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