A Physical-Chemical Study of the Interference of Ceftriaxone Antibiotic with Copper Chloride Salt
The nano-CuCl2.2H2O salt was prepared by the ball milling method. The association parameters for bulk and nano-CuCl2 salts in H2O are estimated at different temperatures using the conductivity method by applying the Fuoss–Shedlovsky equation and it was higher for nano-CuCl2 than bulk CuCl2 salt. The...
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Wiley
2021-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2021/4018843 |
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| author | Elsayed M. AbouElleef Mowafak M. Mahrouka Sherine E. Salem |
| author_facet | Elsayed M. AbouElleef Mowafak M. Mahrouka Sherine E. Salem |
| author_sort | Elsayed M. AbouElleef |
| collection | DOAJ |
| description | The nano-CuCl2.2H2O salt was prepared by the ball milling method. The association parameters for bulk and nano-CuCl2 salts in H2O are estimated at different temperatures using the conductivity method by applying the Fuoss–Shedlovsky equation and it was higher for nano-CuCl2 than bulk CuCl2 salt. The interaction between the cation (Cu2+) and ligand (ceftriaxone) in H2O was determined also by the conductometric method. Two stoichiometric complexes 1/2 and 1/1 (M/L) are estimated and follow the order Kf (1/1) > Kf (1 : 2) and ∆Gf (1/1) > ∆Gf (1/2) for (M : L) (in negative values) indicate the favorable of formation of (1/1) complex compared to the (1 : 2) complex. The Gibbs free energies change was increased in negative signs with increasing the temperature. The antimicrobial activities of CFT, bulk Cu-CFT complex, and nano-Cu-CFT complex were studied on LB agar by the disc diffusion technique against clinical isolates of gram-negative bacteria (Klebsiella pneumonia and Pseudomonas aeruginosa) and Fungi (Candida albicans). It was observed that (CFT) has a higher zone of inhibition and antibacterial activity than that of bulk and nano-Cu-CFT complexes in Klebsiella pneumonia and Pseudomonas aeruginosa (gram-negative bacteria). The nano-Cu-CFT complex showed a higher clear zone of inhibition and antifungal activity against candida than bulk Cu-CFT complex while the absence of the inhibition zone in CFT, so nano-Cu-CFT complex, can be used as an antifungal drug. |
| format | Article |
| id | doaj-art-7823219a787b451aa4012d3917a665be |
| institution | OA Journals |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-7823219a787b451aa4012d3917a665be2025-08-20T02:07:08ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2021-01-01202110.1155/2021/40188434018843A Physical-Chemical Study of the Interference of Ceftriaxone Antibiotic with Copper Chloride SaltElsayed M. AbouElleef0Mowafak M. Mahrouka1Sherine E. Salem2Chemistry Department, Faculty of Arts and Science, Rafha Northern Border University, 91911 Rafha, Saudi ArabiaChemistry Department, Faculty of Arts and Science, Rafha Northern Border University, 91911 Rafha, Saudi ArabiaChemistry Department, Faculty of Science, Mansoura University, 35516 Mansoura, EgyptThe nano-CuCl2.2H2O salt was prepared by the ball milling method. The association parameters for bulk and nano-CuCl2 salts in H2O are estimated at different temperatures using the conductivity method by applying the Fuoss–Shedlovsky equation and it was higher for nano-CuCl2 than bulk CuCl2 salt. The interaction between the cation (Cu2+) and ligand (ceftriaxone) in H2O was determined also by the conductometric method. Two stoichiometric complexes 1/2 and 1/1 (M/L) are estimated and follow the order Kf (1/1) > Kf (1 : 2) and ∆Gf (1/1) > ∆Gf (1/2) for (M : L) (in negative values) indicate the favorable of formation of (1/1) complex compared to the (1 : 2) complex. The Gibbs free energies change was increased in negative signs with increasing the temperature. The antimicrobial activities of CFT, bulk Cu-CFT complex, and nano-Cu-CFT complex were studied on LB agar by the disc diffusion technique against clinical isolates of gram-negative bacteria (Klebsiella pneumonia and Pseudomonas aeruginosa) and Fungi (Candida albicans). It was observed that (CFT) has a higher zone of inhibition and antibacterial activity than that of bulk and nano-Cu-CFT complexes in Klebsiella pneumonia and Pseudomonas aeruginosa (gram-negative bacteria). The nano-Cu-CFT complex showed a higher clear zone of inhibition and antifungal activity against candida than bulk Cu-CFT complex while the absence of the inhibition zone in CFT, so nano-Cu-CFT complex, can be used as an antifungal drug.http://dx.doi.org/10.1155/2021/4018843 |
| spellingShingle | Elsayed M. AbouElleef Mowafak M. Mahrouka Sherine E. Salem A Physical-Chemical Study of the Interference of Ceftriaxone Antibiotic with Copper Chloride Salt Bioinorganic Chemistry and Applications |
| title | A Physical-Chemical Study of the Interference of Ceftriaxone Antibiotic with Copper Chloride Salt |
| title_full | A Physical-Chemical Study of the Interference of Ceftriaxone Antibiotic with Copper Chloride Salt |
| title_fullStr | A Physical-Chemical Study of the Interference of Ceftriaxone Antibiotic with Copper Chloride Salt |
| title_full_unstemmed | A Physical-Chemical Study of the Interference of Ceftriaxone Antibiotic with Copper Chloride Salt |
| title_short | A Physical-Chemical Study of the Interference of Ceftriaxone Antibiotic with Copper Chloride Salt |
| title_sort | physical chemical study of the interference of ceftriaxone antibiotic with copper chloride salt |
| url | http://dx.doi.org/10.1155/2021/4018843 |
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