Immune metabolic restoration in systemic lupus erythematosus: the impact of gut microbiota, probiotics, and nutritional synergy
Gut microbiota alterations have been considered one of the attributes of Systemic Lupus Erythematosus (SLE), and may offer an immunological disorder and even cause the disease. The probiotic administration, especially the Lactobacillus and Bifidobacterium probiotics, is becoming highly utilized for...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1602235/full |
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| author | Douae Nihed Habiballah Fanzhu Li Lai Jiang |
| author_facet | Douae Nihed Habiballah Fanzhu Li Lai Jiang |
| author_sort | Douae Nihed Habiballah |
| collection | DOAJ |
| description | Gut microbiota alterations have been considered one of the attributes of Systemic Lupus Erythematosus (SLE), and may offer an immunological disorder and even cause the disease. The probiotic administration, especially the Lactobacillus and Bifidobacterium probiotics, is becoming highly utilized for the maintenance of the intestinal barrier’s integrity and immune function, minimizing further the risks of developing some complications such as lupus nephritis, mechanisms that have remained so incompletely defined. This review focuses on the analysis of literature data about the influence of certain probiotic strains on the pathogenesis and course of SLE as immunomodulators and a new therapy strategy that seeks to achieve a synergistic effect with the help of an additional probiotic in combination with dietary supplements gingerols or vitamin D. The current review, therefore, provided the limitations in current trials addressing SLE and therapy optimization. The work is done with the intention of addressing the existing gaps in knowledge, thereby creating more space for new approaches to emerge toward the SLE management and improvement of patients’ outcomes. |
| format | Article |
| id | doaj-art-781e42867bf44be099f74dd313cca40e |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-781e42867bf44be099f74dd313cca40e2025-08-20T03:19:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.16022351602235Immune metabolic restoration in systemic lupus erythematosus: the impact of gut microbiota, probiotics, and nutritional synergyDouae Nihed HabiballahFanzhu LiLai JiangGut microbiota alterations have been considered one of the attributes of Systemic Lupus Erythematosus (SLE), and may offer an immunological disorder and even cause the disease. The probiotic administration, especially the Lactobacillus and Bifidobacterium probiotics, is becoming highly utilized for the maintenance of the intestinal barrier’s integrity and immune function, minimizing further the risks of developing some complications such as lupus nephritis, mechanisms that have remained so incompletely defined. This review focuses on the analysis of literature data about the influence of certain probiotic strains on the pathogenesis and course of SLE as immunomodulators and a new therapy strategy that seeks to achieve a synergistic effect with the help of an additional probiotic in combination with dietary supplements gingerols or vitamin D. The current review, therefore, provided the limitations in current trials addressing SLE and therapy optimization. The work is done with the intention of addressing the existing gaps in knowledge, thereby creating more space for new approaches to emerge toward the SLE management and improvement of patients’ outcomes.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1602235/fullsystemic lupus erythematosusprobioticsgut microbiotavitamin D6-gingerolimmune modulation |
| spellingShingle | Douae Nihed Habiballah Fanzhu Li Lai Jiang Immune metabolic restoration in systemic lupus erythematosus: the impact of gut microbiota, probiotics, and nutritional synergy Frontiers in Immunology systemic lupus erythematosus probiotics gut microbiota vitamin D 6-gingerol immune modulation |
| title | Immune metabolic restoration in systemic lupus erythematosus: the impact of gut microbiota, probiotics, and nutritional synergy |
| title_full | Immune metabolic restoration in systemic lupus erythematosus: the impact of gut microbiota, probiotics, and nutritional synergy |
| title_fullStr | Immune metabolic restoration in systemic lupus erythematosus: the impact of gut microbiota, probiotics, and nutritional synergy |
| title_full_unstemmed | Immune metabolic restoration in systemic lupus erythematosus: the impact of gut microbiota, probiotics, and nutritional synergy |
| title_short | Immune metabolic restoration in systemic lupus erythematosus: the impact of gut microbiota, probiotics, and nutritional synergy |
| title_sort | immune metabolic restoration in systemic lupus erythematosus the impact of gut microbiota probiotics and nutritional synergy |
| topic | systemic lupus erythematosus probiotics gut microbiota vitamin D 6-gingerol immune modulation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1602235/full |
| work_keys_str_mv | AT douaenihedhabiballah immunemetabolicrestorationinsystemiclupuserythematosustheimpactofgutmicrobiotaprobioticsandnutritionalsynergy AT fanzhuli immunemetabolicrestorationinsystemiclupuserythematosustheimpactofgutmicrobiotaprobioticsandnutritionalsynergy AT laijiang immunemetabolicrestorationinsystemiclupuserythematosustheimpactofgutmicrobiotaprobioticsandnutritionalsynergy |