Correlation of gallium-68 prostate-specific membrane antigen positron emission tomography – Computed tomography/magnetic resonance imaging with histopathology characteristics in carcinoma prostate patients undergoing radical prostatectomy
Introduction: Gallium-68 prostate-specific membrane antigen positron emission tomography (68Ga-PSMA PET) is being increasingly used in patients with prostate cancer (PCa) for the staging and detection of lymph node (LN) metastases, despite a lack of prospective, validated evidence. We aimed to inves...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Urology |
| Online Access: | https://journals.lww.com/10.4103/iju.iju_143_24 |
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| author | P Taur Pratik Deerush Kannan Sakthivel S Tiwari Madhav P Bafna Sandeep Narasimhan Ragavan |
| author_facet | P Taur Pratik Deerush Kannan Sakthivel S Tiwari Madhav P Bafna Sandeep Narasimhan Ragavan |
| author_sort | P Taur Pratik |
| collection | DOAJ |
| description | Introduction:
Gallium-68 prostate-specific membrane antigen positron emission tomography (68Ga-PSMA PET) is being increasingly used in patients with prostate cancer (PCa) for the staging and detection of lymph node (LN) metastases, despite a lack of prospective, validated evidence. We aimed to investigate the relationship between the PSMA PET findings (maximum standardized uptake [SUVmax] value) and the final histopathology results (Gleason Grade [GG], and LN positivity) in patients undergoing radical prostatectomy.
Methods:
This is a single centre, prospective, observational study of 63 consecutive eligible patients treated at a tertiary care centre in India. Patients underwent 68Ga-PSMA PET computed tomography with fusion magnetic resonance imaging for staging, followed by a Transrectal ultrasound guided prostate biopsy. All patients underwent robotic-assisted radical prostatectomy with extended pelvic LN dissection as per the standard protocol. Clinical parameters and SUVmax values were collected and analysed.
Results:
The median preoperative prostate specific antigen (PSA) was 15.0 ng/ml (interquartile range: 9.4–28.0). A statistically significant correlation was observed between the PSA values and the SUVmax uptake (P < 0.001). Additionally, there was a statistically significant correlation between the SUVmax of the prostatic lesion and the GG on the radical prostatectomy specimens (P = 0.025), and SUVmax of LN and LN involvement (P < 0.001). The sensitivity and specificity of the 68Ga-PSMA PET scan were 77.8% and 88.7%, respectively.
Conclusions:
SUVmax of the PCa lesion and the GG Group on the final histopathology correlates significantly. There is an increased SUV uptake in Gleason’s Score (GS) 8, 9 tumours as compared to GS 6 and 7. |
| format | Article |
| id | doaj-art-780c4c5f8e7b484d81ebce9414a9814a |
| institution | DOAJ |
| issn | 0970-1591 1998-3824 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Urology |
| spelling | doaj-art-780c4c5f8e7b484d81ebce9414a9814a2025-08-20T03:01:02ZengWolters Kluwer Medknow PublicationsIndian Journal of Urology0970-15911998-38242025-01-01411404410.4103/iju.iju_143_24Correlation of gallium-68 prostate-specific membrane antigen positron emission tomography – Computed tomography/magnetic resonance imaging with histopathology characteristics in carcinoma prostate patients undergoing radical prostatectomyP Taur PratikDeerush Kannan SakthivelS Tiwari MadhavP Bafna SandeepNarasimhan RagavanIntroduction: Gallium-68 prostate-specific membrane antigen positron emission tomography (68Ga-PSMA PET) is being increasingly used in patients with prostate cancer (PCa) for the staging and detection of lymph node (LN) metastases, despite a lack of prospective, validated evidence. We aimed to investigate the relationship between the PSMA PET findings (maximum standardized uptake [SUVmax] value) and the final histopathology results (Gleason Grade [GG], and LN positivity) in patients undergoing radical prostatectomy. Methods: This is a single centre, prospective, observational study of 63 consecutive eligible patients treated at a tertiary care centre in India. Patients underwent 68Ga-PSMA PET computed tomography with fusion magnetic resonance imaging for staging, followed by a Transrectal ultrasound guided prostate biopsy. All patients underwent robotic-assisted radical prostatectomy with extended pelvic LN dissection as per the standard protocol. Clinical parameters and SUVmax values were collected and analysed. Results: The median preoperative prostate specific antigen (PSA) was 15.0 ng/ml (interquartile range: 9.4–28.0). A statistically significant correlation was observed between the PSA values and the SUVmax uptake (P < 0.001). Additionally, there was a statistically significant correlation between the SUVmax of the prostatic lesion and the GG on the radical prostatectomy specimens (P = 0.025), and SUVmax of LN and LN involvement (P < 0.001). The sensitivity and specificity of the 68Ga-PSMA PET scan were 77.8% and 88.7%, respectively. Conclusions: SUVmax of the PCa lesion and the GG Group on the final histopathology correlates significantly. There is an increased SUV uptake in Gleason’s Score (GS) 8, 9 tumours as compared to GS 6 and 7.https://journals.lww.com/10.4103/iju.iju_143_24 |
| spellingShingle | P Taur Pratik Deerush Kannan Sakthivel S Tiwari Madhav P Bafna Sandeep Narasimhan Ragavan Correlation of gallium-68 prostate-specific membrane antigen positron emission tomography – Computed tomography/magnetic resonance imaging with histopathology characteristics in carcinoma prostate patients undergoing radical prostatectomy Indian Journal of Urology |
| title | Correlation of gallium-68 prostate-specific membrane antigen positron emission tomography – Computed tomography/magnetic resonance imaging with histopathology characteristics in carcinoma prostate patients undergoing radical prostatectomy |
| title_full | Correlation of gallium-68 prostate-specific membrane antigen positron emission tomography – Computed tomography/magnetic resonance imaging with histopathology characteristics in carcinoma prostate patients undergoing radical prostatectomy |
| title_fullStr | Correlation of gallium-68 prostate-specific membrane antigen positron emission tomography – Computed tomography/magnetic resonance imaging with histopathology characteristics in carcinoma prostate patients undergoing radical prostatectomy |
| title_full_unstemmed | Correlation of gallium-68 prostate-specific membrane antigen positron emission tomography – Computed tomography/magnetic resonance imaging with histopathology characteristics in carcinoma prostate patients undergoing radical prostatectomy |
| title_short | Correlation of gallium-68 prostate-specific membrane antigen positron emission tomography – Computed tomography/magnetic resonance imaging with histopathology characteristics in carcinoma prostate patients undergoing radical prostatectomy |
| title_sort | correlation of gallium 68 prostate specific membrane antigen positron emission tomography computed tomography magnetic resonance imaging with histopathology characteristics in carcinoma prostate patients undergoing radical prostatectomy |
| url | https://journals.lww.com/10.4103/iju.iju_143_24 |
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