<i>Lilium candidum</i> Extract Loaded in Alginate Hydrogel Beads for Chronic Wound Healing
Chronic wounds are a major health problem, affecting millions of people worldwide. Resistance to treatment is frequently observed, requiring an extension of the wound healing time, and improper care can lead to more problems in patients. Smart wound dressings that provide a controlled drug release c...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/11/1/22 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588420739760128 |
|---|---|
| author | Ioana Bâldea Maria-Loredana Soran Adina Stegarescu Ocsana Opriș Irina Kacso Septimiu Tripon Alexandra Adascalitei Iulian George Fericel Roxana Decea Ildiko Lung |
| author_facet | Ioana Bâldea Maria-Loredana Soran Adina Stegarescu Ocsana Opriș Irina Kacso Septimiu Tripon Alexandra Adascalitei Iulian George Fericel Roxana Decea Ildiko Lung |
| author_sort | Ioana Bâldea |
| collection | DOAJ |
| description | Chronic wounds are a major health problem, affecting millions of people worldwide. Resistance to treatment is frequently observed, requiring an extension of the wound healing time, and improper care can lead to more problems in patients. Smart wound dressings that provide a controlled drug release can significantly improve the healing process. In this paper, alginate beads with white lily leaf extract were prepared and tested for chronic wound healing. The obtained beads were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Also, the efficiency of extract encapsulation in alginate was determined as being of. The obtained hydrogel was tested on two normal human cell lines, respectively, dermal fibroblasts (BJ-CRL-2522-ATCC) and endothelial cells (human umbilical vein endothelial cells—HUVEC 2). The longer release of bioactive compounds from plant extract loaded in the alginate hydrogel resulted in more effective wound closure, compared to the extract alone, and scar formation, compared to the alginate hydrogel. Therefore, the effect of the white lily extract in combination with that of sodium alginate hydrogel improves the biological activity of the alginate hydrogel and increases the wound healing properties of the alginate. |
| format | Article |
| id | doaj-art-78088b4dc92f48099a3b1c6a7af5428f |
| institution | Kabale University |
| issn | 2310-2861 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-78088b4dc92f48099a3b1c6a7af5428f2025-01-24T13:33:48ZengMDPI AGGels2310-28612025-01-011112210.3390/gels11010022<i>Lilium candidum</i> Extract Loaded in Alginate Hydrogel Beads for Chronic Wound HealingIoana Bâldea0Maria-Loredana Soran1Adina Stegarescu2Ocsana Opriș3Irina Kacso4Septimiu Tripon5Alexandra Adascalitei6Iulian George Fericel7Roxana Decea8Ildiko Lung9Department of Physiology, Iuliu Haţieganu University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath, 400293 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath, 400293 Cluj-Napoca, RomaniaDepartment of Physiology, Iuliu Haţieganu University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, RomaniaDepartment of Physiology, Iuliu Haţieganu University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, RomaniaDepartment of Physiology, Iuliu Haţieganu University of Medicine and Pharmacy, Clinicilor 1, 400006 Cluj-Napoca, RomaniaNational Institute for Research and Development of Isotopic and Molecular Technologies, 67-103 Donath, 400293 Cluj-Napoca, RomaniaChronic wounds are a major health problem, affecting millions of people worldwide. Resistance to treatment is frequently observed, requiring an extension of the wound healing time, and improper care can lead to more problems in patients. Smart wound dressings that provide a controlled drug release can significantly improve the healing process. In this paper, alginate beads with white lily leaf extract were prepared and tested for chronic wound healing. The obtained beads were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Also, the efficiency of extract encapsulation in alginate was determined as being of. The obtained hydrogel was tested on two normal human cell lines, respectively, dermal fibroblasts (BJ-CRL-2522-ATCC) and endothelial cells (human umbilical vein endothelial cells—HUVEC 2). The longer release of bioactive compounds from plant extract loaded in the alginate hydrogel resulted in more effective wound closure, compared to the extract alone, and scar formation, compared to the alginate hydrogel. Therefore, the effect of the white lily extract in combination with that of sodium alginate hydrogel improves the biological activity of the alginate hydrogel and increases the wound healing properties of the alginate.https://www.mdpi.com/2310-2861/11/1/22white lilypolyphenolsalginate beadsantioxidant capacitychronic wound |
| spellingShingle | Ioana Bâldea Maria-Loredana Soran Adina Stegarescu Ocsana Opriș Irina Kacso Septimiu Tripon Alexandra Adascalitei Iulian George Fericel Roxana Decea Ildiko Lung <i>Lilium candidum</i> Extract Loaded in Alginate Hydrogel Beads for Chronic Wound Healing Gels white lily polyphenols alginate beads antioxidant capacity chronic wound |
| title | <i>Lilium candidum</i> Extract Loaded in Alginate Hydrogel Beads for Chronic Wound Healing |
| title_full | <i>Lilium candidum</i> Extract Loaded in Alginate Hydrogel Beads for Chronic Wound Healing |
| title_fullStr | <i>Lilium candidum</i> Extract Loaded in Alginate Hydrogel Beads for Chronic Wound Healing |
| title_full_unstemmed | <i>Lilium candidum</i> Extract Loaded in Alginate Hydrogel Beads for Chronic Wound Healing |
| title_short | <i>Lilium candidum</i> Extract Loaded in Alginate Hydrogel Beads for Chronic Wound Healing |
| title_sort | i lilium candidum i extract loaded in alginate hydrogel beads for chronic wound healing |
| topic | white lily polyphenols alginate beads antioxidant capacity chronic wound |
| url | https://www.mdpi.com/2310-2861/11/1/22 |
| work_keys_str_mv | AT ioanabaldea ililiumcandidumiextractloadedinalginatehydrogelbeadsforchronicwoundhealing AT marialoredanasoran ililiumcandidumiextractloadedinalginatehydrogelbeadsforchronicwoundhealing AT adinastegarescu ililiumcandidumiextractloadedinalginatehydrogelbeadsforchronicwoundhealing AT ocsanaopris ililiumcandidumiextractloadedinalginatehydrogelbeadsforchronicwoundhealing AT irinakacso ililiumcandidumiextractloadedinalginatehydrogelbeadsforchronicwoundhealing AT septimiutripon ililiumcandidumiextractloadedinalginatehydrogelbeadsforchronicwoundhealing AT alexandraadascalitei ililiumcandidumiextractloadedinalginatehydrogelbeadsforchronicwoundhealing AT iuliangeorgefericel ililiumcandidumiextractloadedinalginatehydrogelbeadsforchronicwoundhealing AT roxanadecea ililiumcandidumiextractloadedinalginatehydrogelbeadsforchronicwoundhealing AT ildikolung ililiumcandidumiextractloadedinalginatehydrogelbeadsforchronicwoundhealing |