Therapeutic potential of vardenafil in preventing sepsis-induced kidney injury: a preclinical study
Sepsis is caused by an infection-induced systemic inflammatory response that may lead to organ failure and death. This study aimed to evaluate the nephroprotective effect of vardenafil, a selective PDE-5 inhibitor, in preventing sepsis-induced kidney injury. Twenty-four male albino Swiss mice with i...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Pensoft Publishers
2025-07-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/158977/download/pdf/ |
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| Summary: | Sepsis is caused by an infection-induced systemic inflammatory response that may lead to organ failure and death. This study aimed to evaluate the nephroprotective effect of vardenafil, a selective PDE-5 inhibitor, in preventing sepsis-induced kidney injury. Twenty-four male albino Swiss mice with induced kidney injury were divided into four groups of six animals. Histological and biomarker examinations were conducted to assess the outcomes. Vardenafil pretreatment significantly reduced creatinine, urea, and KIM-1 levels in CLP mice (p < 0.01). IL-6 and TNF-α levels in renal tissue were also significantly decreased by vardenafil treatment (p < 0.01), leading to a reduced inflammatory response. Vardenafil further inhibited BAX and caspase-3, lowered MDA, and increased antioxidant levels (p < 0.01). Nuclear expression of P-ERK1/2 was markedly reduced in the vardenafil-treated group (p < 0.01). These findings indicate that vardenafil protects the kidneys against CLP-induced sepsis by attenuating inflammation, inhibiting apoptosis, and exerting antioxidant effects. In addition, it has a nephroprotective impact by inhibiting nuclear P-ERK1/2 expression. |
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| ISSN: | 2603-557X |