Targeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study
Abstract Targeted metabolomics was conducted on plasma samples from a nested case-cohort study within the biracial REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. This longitudinal study investigates health outcomes with a focus on stroke disparities across the United State...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-03-01
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| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-025-04746-x |
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| author | Zsuzsanna Ament Naruchorn Kijpaisalratana Varun M. Bhave Catharine A. Couch Ana-Lucia Garcia Guarniz Amit Patki Mary Cushman Suzanne E. Judd M. Ryan Irvin W. Taylor Kimberly |
| author_facet | Zsuzsanna Ament Naruchorn Kijpaisalratana Varun M. Bhave Catharine A. Couch Ana-Lucia Garcia Guarniz Amit Patki Mary Cushman Suzanne E. Judd M. Ryan Irvin W. Taylor Kimberly |
| author_sort | Zsuzsanna Ament |
| collection | DOAJ |
| description | Abstract Targeted metabolomics was conducted on plasma samples from a nested case-cohort study within the biracial REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. This longitudinal study investigates health outcomes with a focus on stroke disparities across the United States, particularly in the Southeastern “Stroke Belt,” where stroke risk and mortality are 2–4 times higher in the Black population. The REGARDS study recruited 30,239 Black and White participants aged 45 years or older. This dataset includes 2,377 baseline plasma samples collected between 2003 and 2007 from a stroke case-cohort sub-study, with 1,056 randomly selected cohort participants and 1,321 stroke cases. The resulting data provides a resource for investigating metabolic profiles and their potential implications for health outcomes and disparities. |
| format | Article |
| id | doaj-art-7805e851c84440828686e526c91e5e2f |
| institution | OA Journals |
| issn | 2052-4463 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Data |
| spelling | doaj-art-7805e851c84440828686e526c91e5e2f2025-08-20T01:57:45ZengNature PortfolioScientific Data2052-44632025-03-011211510.1038/s41597-025-04746-xTargeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) StudyZsuzsanna Ament0Naruchorn Kijpaisalratana1Varun M. Bhave2Catharine A. Couch3Ana-Lucia Garcia Guarniz4Amit Patki5Mary Cushman6Suzanne E. Judd7M. Ryan Irvin8W. Taylor Kimberly9Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical SchoolCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical SchoolHarvard Medical SchoolDepartment of Epidemiology, School of Public Health, University of Alabama at BirminghamCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Biostatistics, School of Public Health, University of Alabama at BirminghamDepartment of Medicine, Larner College of Medicine at the University of VermontDepartment of Biostatistics, School of Public Health, University of Alabama at BirminghamDepartment of Epidemiology, School of Public Health, University of Alabama at BirminghamCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical SchoolAbstract Targeted metabolomics was conducted on plasma samples from a nested case-cohort study within the biracial REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. This longitudinal study investigates health outcomes with a focus on stroke disparities across the United States, particularly in the Southeastern “Stroke Belt,” where stroke risk and mortality are 2–4 times higher in the Black population. The REGARDS study recruited 30,239 Black and White participants aged 45 years or older. This dataset includes 2,377 baseline plasma samples collected between 2003 and 2007 from a stroke case-cohort sub-study, with 1,056 randomly selected cohort participants and 1,321 stroke cases. The resulting data provides a resource for investigating metabolic profiles and their potential implications for health outcomes and disparities.https://doi.org/10.1038/s41597-025-04746-x |
| spellingShingle | Zsuzsanna Ament Naruchorn Kijpaisalratana Varun M. Bhave Catharine A. Couch Ana-Lucia Garcia Guarniz Amit Patki Mary Cushman Suzanne E. Judd M. Ryan Irvin W. Taylor Kimberly Targeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study Scientific Data |
| title | Targeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study |
| title_full | Targeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study |
| title_fullStr | Targeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study |
| title_full_unstemmed | Targeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study |
| title_short | Targeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study |
| title_sort | targeted metabolomics in the reasons for geographic and racial differences in stroke regards study |
| url | https://doi.org/10.1038/s41597-025-04746-x |
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