PPARδ Activity in Cardiovascular Diseases: A Potential Pharmacological Target
Activation of peroxisome proliferator-activated receptors (PPARs), and particularly of PPARα and PPARγ, using selective agonists, is currently used in the treatment of metabolic diseases such as hypertriglyceridemia and type 2 diabetes mellitus. PPARα and PPARγ anti-inflammatory, antiproliferative...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2009/745821 |
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| _version_ | 1849410374263111680 |
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| author | Angela Tesse Ramaroson Andriantsitohaina Thierry Ragot |
| author_facet | Angela Tesse Ramaroson Andriantsitohaina Thierry Ragot |
| author_sort | Angela Tesse |
| collection | DOAJ |
| description | Activation of peroxisome proliferator-activated receptors (PPARs), and particularly of
PPARα and PPARγ, using selective agonists, is currently used in the treatment of metabolic diseases such as hypertriglyceridemia and type 2 diabetes mellitus. PPARα and PPARγ anti-inflammatory, antiproliferative and antiangiogenic properties in cardiovascular cells were
extensively clarified in a variety of in vitro and in vivo models. In contrast, the role of PPARδ in cardiovascular system is poorly understood. Prostacyclin, the predominant prostanoid released by
vascular cells, is a putative endogenous agonist for PPARδ, but only recently PPARδ selective synthetic agonists were found, improving studies about the physiological and pathophysiological roles of PPARδ activation. Recent reports suggest that the PPARδ activation may play a pivotal role to
regulate inflammation, apoptosis, and cell proliferation, suggesting that this transcriptional factor could become an interesting pharmacological target to regulate cardiovascular cell apoptosis, proliferation, inflammation, and metabolism. |
| format | Article |
| id | doaj-art-780106338356469faaa7f5a6bbb97a2c |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-780106338356469faaa7f5a6bbb97a2c2025-08-20T03:35:08ZengWileyPPAR Research1687-47571687-47652009-01-01200910.1155/2009/745821745821PPARδ Activity in Cardiovascular Diseases: A Potential Pharmacological TargetAngela Tesse0Ramaroson Andriantsitohaina1Thierry Ragot2Laboratoire de Biologie Neurovasculaire Intégrée (LBNVI), UMR CNRS 6214/INSERM 771, Faculté de Médecine, Université d'Angers, rue Haute de Reculée, 49045 Angers Cedex 01, FranceLaboratoire de Biologie Neurovasculaire Intégrée (LBNVI), UMR CNRS 6214/INSERM 771, Faculté de Médecine, Université d'Angers, rue Haute de Reculée, 49045 Angers Cedex 01, FranceInstitut de Cancérologie Gustave Roussy (IGR), CNRS UMRY 8121, PR2, 39 rue Camille Desmoulins, 94805 Villejuif, FranceActivation of peroxisome proliferator-activated receptors (PPARs), and particularly of PPARα and PPARγ, using selective agonists, is currently used in the treatment of metabolic diseases such as hypertriglyceridemia and type 2 diabetes mellitus. PPARα and PPARγ anti-inflammatory, antiproliferative and antiangiogenic properties in cardiovascular cells were extensively clarified in a variety of in vitro and in vivo models. In contrast, the role of PPARδ in cardiovascular system is poorly understood. Prostacyclin, the predominant prostanoid released by vascular cells, is a putative endogenous agonist for PPARδ, but only recently PPARδ selective synthetic agonists were found, improving studies about the physiological and pathophysiological roles of PPARδ activation. Recent reports suggest that the PPARδ activation may play a pivotal role to regulate inflammation, apoptosis, and cell proliferation, suggesting that this transcriptional factor could become an interesting pharmacological target to regulate cardiovascular cell apoptosis, proliferation, inflammation, and metabolism.http://dx.doi.org/10.1155/2009/745821 |
| spellingShingle | Angela Tesse Ramaroson Andriantsitohaina Thierry Ragot PPARδ Activity in Cardiovascular Diseases: A Potential Pharmacological Target PPAR Research |
| title | PPARδ Activity in Cardiovascular Diseases: A Potential Pharmacological Target |
| title_full | PPARδ Activity in Cardiovascular Diseases: A Potential Pharmacological Target |
| title_fullStr | PPARδ Activity in Cardiovascular Diseases: A Potential Pharmacological Target |
| title_full_unstemmed | PPARδ Activity in Cardiovascular Diseases: A Potential Pharmacological Target |
| title_short | PPARδ Activity in Cardiovascular Diseases: A Potential Pharmacological Target |
| title_sort | pparδ activity in cardiovascular diseases a potential pharmacological target |
| url | http://dx.doi.org/10.1155/2009/745821 |
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