Circular PVT1 promotes cardiac fibroblast activation interacting with miR-30a-5p and miR-125b-5p

Circular PVT1 promotes cardiac fibroblast activation interacting with miR-30a-5p and miR-125b-5p

Abstract Circular RNAs (circRNAs) are involved in the pathogenesis of several cardiovascular diseases, including heart failure. In this study, we report that circular PVT1 (circPVT1) was upregulated in the left ventricle of 31 ischemic heart failure patients compared to 11 non-ischemic controls. RNA...

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Main Authors: Alessia Bibi, Alisia Madè, Simona Greco, Jose Manuel Garcia-Manteiga, Anna Sofia Tascini, Spyros Tastsoglou, Germana Zaccagnini, Przemyslaw Leszek, Carlo Gaetano, Fabio Martelli
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07652-7
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