Neuroblastoma in the Elderly and SIADH: Case Report and Review of the Literature
Objective. To report the rare case of a thymic neuroblastoma, in an elderly woman with SIADH at presentation. Methods. Clinical and biochemical data of the patient are presented and the pertinent literature is reviewed. Results. a 79-year-old woman was admitted into our department with worsening ast...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/952645 |
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| author | Micaela Pellegrino Laura Gianotti Sara Cassibba Rodolfo Brizio Alberto Terzi Giorgio Borretta |
| author_facet | Micaela Pellegrino Laura Gianotti Sara Cassibba Rodolfo Brizio Alberto Terzi Giorgio Borretta |
| author_sort | Micaela Pellegrino |
| collection | DOAJ |
| description | Objective. To report the rare case of a thymic neuroblastoma, in an elderly woman with SIADH at presentation. Methods. Clinical and biochemical data of the patient are presented and the pertinent literature is reviewed. Results. a 79-year-old woman was admitted into our department with worsening asthenia, severe hyponatremia (114.8 mEq/L), low plasma osmolarity (253 mEq/L), and inappropriate urinary sodium concentration (151 mEq/L). CT scan showed an a large solid inhomogeneous mass in the anterior mediastinum. 18F-FDG-PET/CT showed uptake in the mass. On continuous 3% hypertonic saline infusion, sodium gradually increased without achieving normal values. The patient underwent surgery, followed by full normalization of sodium levels. Tumor cells were positive for neuroendocrine markers. Thymic neuroblastoma with SIADH was diagnosed. Conclusions. Neuroblastoma is an extremely rare tumor in the elderly. Contrary to children and younger adults, neuroblastoma in older adults is typically localized in the anterior mediastinum and is often associated with SIADH. Moreover, it has mainly local aggressiveness in this age group, without metastatic spread; thus radical surgery achieves cure in most cases. |
| format | Article |
| id | doaj-art-77fea7f98aea4ff2955b770d322e16c9 |
| institution | OA Journals |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-77fea7f98aea4ff2955b770d322e16c92025-08-20T02:07:06ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/952645952645Neuroblastoma in the Elderly and SIADH: Case Report and Review of the LiteratureMicaela Pellegrino0Laura Gianotti1Sara Cassibba2Rodolfo Brizio3Alberto Terzi4Giorgio Borretta5Division of Endocrinology and Metabolism, Department of Internal Medicine, S. Croce e Carle Hospital, Via M. Coppino 26, 12100 Cuneo, ItalyDivision of Endocrinology and Metabolism, Department of Internal Medicine, S. Croce e Carle Hospital, Via M. Coppino 26, 12100 Cuneo, ItalyDivision of Endocrinology and Metabolism, Department of Internal Medicine, S. Croce e Carle Hospital, Via M. Coppino 26, 12100 Cuneo, ItalyDepartment of Pathology, S. Croce e Carle Hospital, Via M. Coppino 26, 12100 Cuneo, ItalyThoracic Surgery Unit, S. Croce e Carle Hospital, Via M. Coppino 26, 12100 Cuneo, ItalyDivision of Endocrinology and Metabolism, Department of Internal Medicine, S. Croce e Carle Hospital, Via M. Coppino 26, 12100 Cuneo, ItalyObjective. To report the rare case of a thymic neuroblastoma, in an elderly woman with SIADH at presentation. Methods. Clinical and biochemical data of the patient are presented and the pertinent literature is reviewed. Results. a 79-year-old woman was admitted into our department with worsening asthenia, severe hyponatremia (114.8 mEq/L), low plasma osmolarity (253 mEq/L), and inappropriate urinary sodium concentration (151 mEq/L). CT scan showed an a large solid inhomogeneous mass in the anterior mediastinum. 18F-FDG-PET/CT showed uptake in the mass. On continuous 3% hypertonic saline infusion, sodium gradually increased without achieving normal values. The patient underwent surgery, followed by full normalization of sodium levels. Tumor cells were positive for neuroendocrine markers. Thymic neuroblastoma with SIADH was diagnosed. Conclusions. Neuroblastoma is an extremely rare tumor in the elderly. Contrary to children and younger adults, neuroblastoma in older adults is typically localized in the anterior mediastinum and is often associated with SIADH. Moreover, it has mainly local aggressiveness in this age group, without metastatic spread; thus radical surgery achieves cure in most cases.http://dx.doi.org/10.1155/2012/952645 |
| spellingShingle | Micaela Pellegrino Laura Gianotti Sara Cassibba Rodolfo Brizio Alberto Terzi Giorgio Borretta Neuroblastoma in the Elderly and SIADH: Case Report and Review of the Literature Case Reports in Medicine |
| title | Neuroblastoma in the Elderly and SIADH: Case Report and Review of the Literature |
| title_full | Neuroblastoma in the Elderly and SIADH: Case Report and Review of the Literature |
| title_fullStr | Neuroblastoma in the Elderly and SIADH: Case Report and Review of the Literature |
| title_full_unstemmed | Neuroblastoma in the Elderly and SIADH: Case Report and Review of the Literature |
| title_short | Neuroblastoma in the Elderly and SIADH: Case Report and Review of the Literature |
| title_sort | neuroblastoma in the elderly and siadh case report and review of the literature |
| url | http://dx.doi.org/10.1155/2012/952645 |
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