Anxiety, depression and impaired health-related quality of life are therapeutic challenges in patients with multiple sclerosis
Anxiety, depression and impaired health-related quality of life (HRQoL) are commonly reported in patients with multiple sclerosis (MS) and are of great interest for therapeutic approaches. Based on regional differences a quantitative assessment of these factors in comparison to the general populatio...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mental Illness |
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| Online Access: | http://www.pagepress.org/journals/index.php/mi/article/view/1747 |
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| author | Florian Then Bergh Susanne Singer Andreas Hinz Eva Thomae Dominik Michalski Stefanie Liebig |
| author_facet | Florian Then Bergh Susanne Singer Andreas Hinz Eva Thomae Dominik Michalski Stefanie Liebig |
| author_sort | Florian Then Bergh |
| collection | DOAJ |
| description | Anxiety, depression and impaired health-related quality of life (HRQoL) are commonly reported in patients with multiple sclerosis (MS) and are of great interest for therapeutic approaches. Based on regional differences a quantitative assessment of these factors in comparison to the general population, and the consideration of demographic cofactors, would be useful when designing specific interventions. We adopted such an approach in a German cohort of MS patients. Anxiety, depression (HADS) and HRQoL (SF-36) were measured in 49 consecutive outpatients with MS and compared to age- and gender-adjusted control groups (n=1330 for HADS; n=5087 for SF-36) extracted from German National Health Surveys. Patients with MS showed significantly increased levels of anxiety and depression as well as decreased HRQoL with the exception of mental health; the effect sizes ranged from 0.39 (depression) to 1.06 (physical functioning). As could be expected, MS patients with relapsing-remitting clinical course had better physical functioning than patients with secondary progressive MS. There were strong relations between anxiety and depression (r=0.54; P less than 0.01), and between neurological impairment (EDSS) and physical functioning (r=-0.80; P less than 0.001) as well as depression (r=0.48; P less than 0.05). This investigation of MS patients confirms the prevalence and impact of anxiety, depression and most of the HRQoL dimensions in MS patients and provides evidence for the usefulness of a quantitative comparison to a region-specific general population as a starting point for therapeutic approaches. |
| format | Article |
| id | doaj-art-77fd6e686a20443d9c5d6a0e72016ade |
| institution | OA Journals |
| issn | 2036-7457 2036-7465 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mental Illness |
| spelling | doaj-art-77fd6e686a20443d9c5d6a0e72016ade2025-08-20T02:07:06ZengWileyMental Illness2036-74572036-74652010-01-0121e5e510.4081/mi.2010.e5Anxiety, depression and impaired health-related quality of life are therapeutic challenges in patients with multiple sclerosisFlorian Then BerghSusanne SingerAndreas HinzEva ThomaeDominik MichalskiStefanie LiebigAnxiety, depression and impaired health-related quality of life (HRQoL) are commonly reported in patients with multiple sclerosis (MS) and are of great interest for therapeutic approaches. Based on regional differences a quantitative assessment of these factors in comparison to the general population, and the consideration of demographic cofactors, would be useful when designing specific interventions. We adopted such an approach in a German cohort of MS patients. Anxiety, depression (HADS) and HRQoL (SF-36) were measured in 49 consecutive outpatients with MS and compared to age- and gender-adjusted control groups (n=1330 for HADS; n=5087 for SF-36) extracted from German National Health Surveys. Patients with MS showed significantly increased levels of anxiety and depression as well as decreased HRQoL with the exception of mental health; the effect sizes ranged from 0.39 (depression) to 1.06 (physical functioning). As could be expected, MS patients with relapsing-remitting clinical course had better physical functioning than patients with secondary progressive MS. There were strong relations between anxiety and depression (r=0.54; P less than 0.01), and between neurological impairment (EDSS) and physical functioning (r=-0.80; P less than 0.001) as well as depression (r=0.48; P less than 0.05). This investigation of MS patients confirms the prevalence and impact of anxiety, depression and most of the HRQoL dimensions in MS patients and provides evidence for the usefulness of a quantitative comparison to a region-specific general population as a starting point for therapeutic approaches.http://www.pagepress.org/journals/index.php/mi/article/view/1747AnxietyDepressionHealth-related quality of lifemultiple sclerosis |
| spellingShingle | Florian Then Bergh Susanne Singer Andreas Hinz Eva Thomae Dominik Michalski Stefanie Liebig Anxiety, depression and impaired health-related quality of life are therapeutic challenges in patients with multiple sclerosis Mental Illness Anxiety Depression Health-related quality of life multiple sclerosis |
| title | Anxiety, depression and impaired health-related quality of life are therapeutic challenges in patients with multiple sclerosis |
| title_full | Anxiety, depression and impaired health-related quality of life are therapeutic challenges in patients with multiple sclerosis |
| title_fullStr | Anxiety, depression and impaired health-related quality of life are therapeutic challenges in patients with multiple sclerosis |
| title_full_unstemmed | Anxiety, depression and impaired health-related quality of life are therapeutic challenges in patients with multiple sclerosis |
| title_short | Anxiety, depression and impaired health-related quality of life are therapeutic challenges in patients with multiple sclerosis |
| title_sort | anxiety depression and impaired health related quality of life are therapeutic challenges in patients with multiple sclerosis |
| topic | Anxiety Depression Health-related quality of life multiple sclerosis |
| url | http://www.pagepress.org/journals/index.php/mi/article/view/1747 |
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