The Relationship Between Changes in the Neutrophil-Lymphocyte Ratio (NLR) and Radiological Progression in Cervical Cancer
Introduction: Peripheral counts of neutrophils and lymphocytes and their changes have been associated with disease prognosis in various malignancies. While several studies have investigated the changes and clinical implications of the peripheral blood neutrophil to lymphocyte ratio (NLR) in cervical...
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Galenos Yayinevi
2025-08-01
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| Series: | İstanbul Medical Journal |
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| Online Access: | https://www.istanbulmedicaljournal.org/articles/the-relationship-between-changes-in-the-neutrophil-lymphocyte-ratio-nlr-and-radiological-progression-in-cervical-cancer/doi/imj.galenos.2025.59254 |
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| author | Rumeysa Çolak İlkay Gültürk Ezgi Değerli Caner Kapar Seher Yıldız Tacar Mesut Yılmaz |
| author_facet | Rumeysa Çolak İlkay Gültürk Ezgi Değerli Caner Kapar Seher Yıldız Tacar Mesut Yılmaz |
| author_sort | Rumeysa Çolak |
| collection | DOAJ |
| description | Introduction: Peripheral counts of neutrophils and lymphocytes and their changes have been associated with disease prognosis in various malignancies. While several studies have investigated the changes and clinical implications of the peripheral blood neutrophil to lymphocyte ratio (NLR) in cervical cancer, the prognostic value of NLR, in locally advanced cervical cancer remains unclear.
Methods: A retrospective analysis of cervical cancer patients who received definitive chemoradiotherapy (CRT) was carried out. NLR values were identified pre-CRT and post-CRT, and changes in these values were calculated. We assessed the relationship between changes in the NLR and clinicopathological features and disease prognosis.
Results: A total of eighty-five patients with locally advanced cervical cancer who received CRT were analyzed in this study. The rate of decrease in NLR in patients with progression was 22.2%, while in patients without progression was 17.2%. The rate of increase in NLR in patients with progression was 77.8%, while in patients without progression it was 82.8%. Higher or lower NLR levels were not found to have a significant relationship with disease progression (p=0.584).
Conclusion: The impact of changes in NLR on the prognosis of cervical cancer patients needs further validation in multicenter studies. |
| format | Article |
| id | doaj-art-77fb62c9fcce4e59ae73f9228d35bf7c |
| institution | Kabale University |
| issn | 2619-9793 2148-094X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | İstanbul Medical Journal |
| spelling | doaj-art-77fb62c9fcce4e59ae73f9228d35bf7c2025-08-20T03:45:14ZengGalenos Yayineviİstanbul Medical Journal2619-97932148-094X2025-08-0126321121510.4274/imj.galenos.2025.59254The Relationship Between Changes in the Neutrophil-Lymphocyte Ratio (NLR) and Radiological Progression in Cervical CancerRumeysa Çolak0https://orcid.org/0000-0002-3867-0793İlkay Gültürk1https://orcid.org/0000-0003-1998-3150Ezgi Değerli2https://orcid.org/0000-0002-8664-5701Caner Kapar3https://orcid.org/0000-0002-8879-8533Seher Yıldız Tacar4https://orcid.org/0000-0001-7581-0962Mesut Yılmaz5https://orcid.org/0000-0001-7581-0962University of Health Sciences Türkiye, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Clinic of Medical Oncology, İstanbul, TürkiyeUniversity of Health Sciences Türkiye, İstanbul Training and Research Hospital, Clinic of Medical Oncology, İstanbul, TürkiyeUniversity of Health Sciences Türkiye, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Clinic of Medical Oncology, İstanbul, TürkiyeUniversity of Health Sciences Türkiye, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Clinic of Medical Oncology, İstanbul, TürkiyeUniversity of Health Sciences Türkiye, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Clinic of Medical Oncology, İstanbul, TürkiyeUniversity of Health Sciences Türkiye, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Clinic of Medical Oncology, İstanbul, TürkiyeIntroduction: Peripheral counts of neutrophils and lymphocytes and their changes have been associated with disease prognosis in various malignancies. While several studies have investigated the changes and clinical implications of the peripheral blood neutrophil to lymphocyte ratio (NLR) in cervical cancer, the prognostic value of NLR, in locally advanced cervical cancer remains unclear. Methods: A retrospective analysis of cervical cancer patients who received definitive chemoradiotherapy (CRT) was carried out. NLR values were identified pre-CRT and post-CRT, and changes in these values were calculated. We assessed the relationship between changes in the NLR and clinicopathological features and disease prognosis. Results: A total of eighty-five patients with locally advanced cervical cancer who received CRT were analyzed in this study. The rate of decrease in NLR in patients with progression was 22.2%, while in patients without progression was 17.2%. The rate of increase in NLR in patients with progression was 77.8%, while in patients without progression it was 82.8%. Higher or lower NLR levels were not found to have a significant relationship with disease progression (p=0.584). Conclusion: The impact of changes in NLR on the prognosis of cervical cancer patients needs further validation in multicenter studies.https://www.istanbulmedicaljournal.org/articles/the-relationship-between-changes-in-the-neutrophil-lymphocyte-ratio-nlr-and-radiological-progression-in-cervical-cancer/doi/imj.galenos.2025.59254cervical cancerdefinitive chemoradiotherapyneutrophil-to-lymphocyte ratioprognosis |
| spellingShingle | Rumeysa Çolak İlkay Gültürk Ezgi Değerli Caner Kapar Seher Yıldız Tacar Mesut Yılmaz The Relationship Between Changes in the Neutrophil-Lymphocyte Ratio (NLR) and Radiological Progression in Cervical Cancer İstanbul Medical Journal cervical cancer definitive chemoradiotherapy neutrophil-to-lymphocyte ratio prognosis |
| title | The Relationship Between Changes in the Neutrophil-Lymphocyte Ratio (NLR) and Radiological Progression in Cervical Cancer |
| title_full | The Relationship Between Changes in the Neutrophil-Lymphocyte Ratio (NLR) and Radiological Progression in Cervical Cancer |
| title_fullStr | The Relationship Between Changes in the Neutrophil-Lymphocyte Ratio (NLR) and Radiological Progression in Cervical Cancer |
| title_full_unstemmed | The Relationship Between Changes in the Neutrophil-Lymphocyte Ratio (NLR) and Radiological Progression in Cervical Cancer |
| title_short | The Relationship Between Changes in the Neutrophil-Lymphocyte Ratio (NLR) and Radiological Progression in Cervical Cancer |
| title_sort | relationship between changes in the neutrophil lymphocyte ratio nlr and radiological progression in cervical cancer |
| topic | cervical cancer definitive chemoradiotherapy neutrophil-to-lymphocyte ratio prognosis |
| url | https://www.istanbulmedicaljournal.org/articles/the-relationship-between-changes-in-the-neutrophil-lymphocyte-ratio-nlr-and-radiological-progression-in-cervical-cancer/doi/imj.galenos.2025.59254 |
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