Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols
Reactive oxygen species (ROS) imbalance and mitochondrial dysfunction played critical roles in the pathogenesis of cardiovascular diseases which are the leading cause of death worldwide. Mitochondrion is the main ROS production, which is also the vulnerable target for ROS attack. Compelling evidence...
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| Format: | Article |
| Language: | zho |
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The editorial department of Science and Technology of Food Industry
2025-02-01
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| Series: | Shipin gongye ke-ji |
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| Online Access: | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024040263 |
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| author | Tingting DENG Jinchan PI Xiaoping PENG Yufei YAO Yiquan LI Wenjuan LI |
| author_facet | Tingting DENG Jinchan PI Xiaoping PENG Yufei YAO Yiquan LI Wenjuan LI |
| author_sort | Tingting DENG |
| collection | DOAJ |
| description | Reactive oxygen species (ROS) imbalance and mitochondrial dysfunction played critical roles in the pathogenesis of cardiovascular diseases which are the leading cause of death worldwide. Mitochondrion is the main ROS production, which is also the vulnerable target for ROS attack. Compelling evidence has been provided that tea polyphenols could regulate ROS generation and protect mitochondrial structure and function, contributing to its beneficial health effects on cardiovascular protection. Hence, the article introduces the sources and detrimental effects of ROS, then the intrinsic connections between ROS, mitochondria, and the development of cardiovascular diseases, as well as the ROS-scavenging effects of tea polyphenols are summarized. From the perspective of ROS-mitochondrial pathway, the article elucidates how tea polyphenols behaved the beneficial effects against cardiovascular diseases by modulating the expression of mitochondrial fusion and fission proteins, reducing the opening of mitochondrial membrane permeability transition pore, maintaining cellular calcium homeostasis, mitigating mitochondrial DNA damage and regulating mitochondrial apoptosis signaling pathways. Correspondingly, the potential applications of tea polyphenols are discussed, aiming to provide valuable insights for research and application in related fields. |
| format | Article |
| id | doaj-art-77f865d4756b448fa0364513c4032d45 |
| institution | Kabale University |
| issn | 1002-0306 |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | The editorial department of Science and Technology of Food Industry |
| record_format | Article |
| series | Shipin gongye ke-ji |
| spelling | doaj-art-77f865d4756b448fa0364513c4032d452025-02-08T08:06:21ZzhoThe editorial department of Science and Technology of Food IndustryShipin gongye ke-ji1002-03062025-02-0146443444210.13386/j.issn1002-0306.20240402632024040263-4Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea PolyphenolsTingting DENG0Jinchan PI1Xiaoping PENG2Yufei YAO3Yiquan LI4Wenjuan LI5State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, ChinaFirst Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaAffiliated Hospital of Jiangxi Traditional Chinese Medicine University, Nanchang 330006, ChinaJiangxi Taiyang Hong Tea Industry Co., Ltd., Jiujiang 332300, ChinaState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, ChinaReactive oxygen species (ROS) imbalance and mitochondrial dysfunction played critical roles in the pathogenesis of cardiovascular diseases which are the leading cause of death worldwide. Mitochondrion is the main ROS production, which is also the vulnerable target for ROS attack. Compelling evidence has been provided that tea polyphenols could regulate ROS generation and protect mitochondrial structure and function, contributing to its beneficial health effects on cardiovascular protection. Hence, the article introduces the sources and detrimental effects of ROS, then the intrinsic connections between ROS, mitochondria, and the development of cardiovascular diseases, as well as the ROS-scavenging effects of tea polyphenols are summarized. From the perspective of ROS-mitochondrial pathway, the article elucidates how tea polyphenols behaved the beneficial effects against cardiovascular diseases by modulating the expression of mitochondrial fusion and fission proteins, reducing the opening of mitochondrial membrane permeability transition pore, maintaining cellular calcium homeostasis, mitigating mitochondrial DNA damage and regulating mitochondrial apoptosis signaling pathways. Correspondingly, the potential applications of tea polyphenols are discussed, aiming to provide valuable insights for research and application in related fields.http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024040263reactive oxygen species (ros)mitochondriacardiovascular diseasetea polyphenolssignal transduction mechanism |
| spellingShingle | Tingting DENG Jinchan PI Xiaoping PENG Yufei YAO Yiquan LI Wenjuan LI Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols Shipin gongye ke-ji reactive oxygen species (ros) mitochondria cardiovascular disease tea polyphenols signal transduction mechanism |
| title | Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols |
| title_full | Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols |
| title_fullStr | Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols |
| title_full_unstemmed | Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols |
| title_short | Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols |
| title_sort | research progress of ros mitochondrial pathway on cardiovascular protection of tea polyphenols |
| topic | reactive oxygen species (ros) mitochondria cardiovascular disease tea polyphenols signal transduction mechanism |
| url | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024040263 |
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