Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease
Celiac disease is usually diagnosed by demonstrating gluten enteropathy in small bowel biopsy. Celiac specific antibodies are used as an initial screening test. The goal of this study is to test the relationship of the anti-tTG titer and severity of histological changes in Jordanian children with ce...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/6718590 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558107036745728 |
|---|---|
| author | Hasan Hawamdeh Basim Al-Zoubi Yasameen Al Sharqi Ayman Qasrawi Yousef Abdelaziz Maha Barbar |
| author_facet | Hasan Hawamdeh Basim Al-Zoubi Yasameen Al Sharqi Ayman Qasrawi Yousef Abdelaziz Maha Barbar |
| author_sort | Hasan Hawamdeh |
| collection | DOAJ |
| description | Celiac disease is usually diagnosed by demonstrating gluten enteropathy in small bowel biopsy. Celiac specific antibodies are used as an initial screening test. The goal of this study is to test the relationship of the anti-tTG titer and severity of histological changes in Jordanian children with celiac disease. Method. The medical records of 81 children who had elevated anti-tTG titer and had duodenal biopsies available were retrospectively reviewed. Result. Assessing the association of anti-tTG titer with duodenal histopathological changes, 94% of those with high anti-tTG titer (≥180 U/mL) had histological evidence of celiac disease. There was statistically significant positive association between high anti-tTG titer and Marsh grading as 82% of patients with Marsh III had high anti-tTG titer (Chi2 18.5; P value 0.00; Odds Ratio 8.5). The fraction of patients with Marsh III who were correctly identified as positive by anti-tTG titer ≥ 180 U/mL was high (sensitivity = 81.6). Moreover, the fraction of patients with anti-tTG titer ≥ 180 U/mL who had Marsh III was also high (positive predictive value = 78.4). Conclusion. Anti-tTG titer ≥ 180 U/mL had significant positive association with Marsh III histopathological changes of celiac disease. |
| format | Article |
| id | doaj-art-77f4b70cb5b84ad894f0d2cd5d3e38cd |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-77f4b70cb5b84ad894f0d2cd5d3e38cd2025-02-03T01:33:16ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/67185906718590Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac DiseaseHasan Hawamdeh0Basim Al-Zoubi1Yasameen Al Sharqi2Ayman Qasrawi3Yousef Abdelaziz4Maha Barbar5Department of Pediatrics, Hashemite University, P.O. Box 1504514, Zarqa 13115, JordanDepartment of Pediatrics, Prince Hamzah Hospital, P.O. Box 86, Amman 11118, JordanDepartment of Pathology, Prince Hamzah Hospital, P.O. Box 86, Amman 11118, JordanDepartment of Pediatrics, Prince Hamzah Hospital, P.O. Box 86, Amman 11118, JordanDepartment of Pediatrics, Prince Hamzah Hospital, P.O. Box 86, Amman 11118, JordanDepartment of Pediatrics, Hashemite University, P.O. Box 1504514, Zarqa 13115, JordanCeliac disease is usually diagnosed by demonstrating gluten enteropathy in small bowel biopsy. Celiac specific antibodies are used as an initial screening test. The goal of this study is to test the relationship of the anti-tTG titer and severity of histological changes in Jordanian children with celiac disease. Method. The medical records of 81 children who had elevated anti-tTG titer and had duodenal biopsies available were retrospectively reviewed. Result. Assessing the association of anti-tTG titer with duodenal histopathological changes, 94% of those with high anti-tTG titer (≥180 U/mL) had histological evidence of celiac disease. There was statistically significant positive association between high anti-tTG titer and Marsh grading as 82% of patients with Marsh III had high anti-tTG titer (Chi2 18.5; P value 0.00; Odds Ratio 8.5). The fraction of patients with Marsh III who were correctly identified as positive by anti-tTG titer ≥ 180 U/mL was high (sensitivity = 81.6). Moreover, the fraction of patients with anti-tTG titer ≥ 180 U/mL who had Marsh III was also high (positive predictive value = 78.4). Conclusion. Anti-tTG titer ≥ 180 U/mL had significant positive association with Marsh III histopathological changes of celiac disease.http://dx.doi.org/10.1155/2016/6718590 |
| spellingShingle | Hasan Hawamdeh Basim Al-Zoubi Yasameen Al Sharqi Ayman Qasrawi Yousef Abdelaziz Maha Barbar Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease Gastroenterology Research and Practice |
| title | Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease |
| title_full | Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease |
| title_fullStr | Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease |
| title_full_unstemmed | Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease |
| title_short | Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease |
| title_sort | association of tissue transglutaminase antibody titer with duodenal histological changes in children with celiac disease |
| url | http://dx.doi.org/10.1155/2016/6718590 |
| work_keys_str_mv | AT hasanhawamdeh associationoftissuetransglutaminaseantibodytiterwithduodenalhistologicalchangesinchildrenwithceliacdisease AT basimalzoubi associationoftissuetransglutaminaseantibodytiterwithduodenalhistologicalchangesinchildrenwithceliacdisease AT yasameenalsharqi associationoftissuetransglutaminaseantibodytiterwithduodenalhistologicalchangesinchildrenwithceliacdisease AT aymanqasrawi associationoftissuetransglutaminaseantibodytiterwithduodenalhistologicalchangesinchildrenwithceliacdisease AT yousefabdelaziz associationoftissuetransglutaminaseantibodytiterwithduodenalhistologicalchangesinchildrenwithceliacdisease AT mahabarbar associationoftissuetransglutaminaseantibodytiterwithduodenalhistologicalchangesinchildrenwithceliacdisease |