TO THE PROBLEM OF EXPERIMENTAL-MORPHOLOGICAL STUDIES OF RADIATION-INDUCED THYROID DISEASES
The thyroid gland of 30 4-month-old male Wistar rats was studied. The control group consisted of 5 rats. Twenty-five rats received whole body ionizing radiation with γ-quantum in sublethal dose using the gamma therapeutical apparatus AGAT R1. Animals were killed 2, 5, 10, 15 и 30 days after irradiat...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/251 |
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| author | Yu. M. Iryanov G. N. Filimonova |
| author_facet | Yu. M. Iryanov G. N. Filimonova |
| author_sort | Yu. M. Iryanov |
| collection | DOAJ |
| description | The thyroid gland of 30 4-month-old male Wistar rats was studied. The control group consisted of 5 rats. Twenty-five rats received whole body ionizing radiation with γ-quantum in sublethal dose using the gamma therapeutical apparatus AGAT R1. Animals were killed 2, 5, 10, 15 и 30 days after irradiation (n=5). Histomorphometric analysis included measurements of external follicle diameter, nuclear diameter and area, colloid area, follicular epithelium area, Braun index, nuclear/cytoplasmic ratio and follicular/colloid index. At the end of the experimental study, all morphometric criteria were higher than the control values, especially nuclear area, indicating neoplastic transformation of thyroid. Histograms of distribution of thyrocyte nuclear area were dome-shaped in all days of the experimental study except day 2 characterizing follicular and papillary thyroid cancers. The given work is a prospective experimental-morphological study of radiation-induced neuroendocrine cancers |
| format | Article |
| id | doaj-art-77f3f07529bf4aeca6af0791789393ad |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-77f3f07529bf4aeca6af0791789393ad2025-08-20T03:35:50ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01163135251TO THE PROBLEM OF EXPERIMENTAL-MORPHOLOGICAL STUDIES OF RADIATION-INDUCED THYROID DISEASESYu. M. Iryanov0G. N. Filimonova1Russian Research Center of Traumatology and Orthopedics named after Academician G.A. Ilizarov, KurganRussian Research Center of Traumatology and Orthopedics named after Academician G.A. Ilizarov, KurganThe thyroid gland of 30 4-month-old male Wistar rats was studied. The control group consisted of 5 rats. Twenty-five rats received whole body ionizing radiation with γ-quantum in sublethal dose using the gamma therapeutical apparatus AGAT R1. Animals were killed 2, 5, 10, 15 и 30 days after irradiation (n=5). Histomorphometric analysis included measurements of external follicle diameter, nuclear diameter and area, colloid area, follicular epithelium area, Braun index, nuclear/cytoplasmic ratio and follicular/colloid index. At the end of the experimental study, all morphometric criteria were higher than the control values, especially nuclear area, indicating neoplastic transformation of thyroid. Histograms of distribution of thyrocyte nuclear area were dome-shaped in all days of the experimental study except day 2 characterizing follicular and papillary thyroid cancers. The given work is a prospective experimental-morphological study of radiation-induced neuroendocrine cancershttps://www.siboncoj.ru/jour/article/view/251thyroid cancergamma radiationacute radiation-induced diseasehistomorphometrypapillary cancer |
| spellingShingle | Yu. M. Iryanov G. N. Filimonova TO THE PROBLEM OF EXPERIMENTAL-MORPHOLOGICAL STUDIES OF RADIATION-INDUCED THYROID DISEASES Сибирский онкологический журнал thyroid cancer gamma radiation acute radiation-induced disease histomorphometry papillary cancer |
| title | TO THE PROBLEM OF EXPERIMENTAL-MORPHOLOGICAL STUDIES OF RADIATION-INDUCED THYROID DISEASES |
| title_full | TO THE PROBLEM OF EXPERIMENTAL-MORPHOLOGICAL STUDIES OF RADIATION-INDUCED THYROID DISEASES |
| title_fullStr | TO THE PROBLEM OF EXPERIMENTAL-MORPHOLOGICAL STUDIES OF RADIATION-INDUCED THYROID DISEASES |
| title_full_unstemmed | TO THE PROBLEM OF EXPERIMENTAL-MORPHOLOGICAL STUDIES OF RADIATION-INDUCED THYROID DISEASES |
| title_short | TO THE PROBLEM OF EXPERIMENTAL-MORPHOLOGICAL STUDIES OF RADIATION-INDUCED THYROID DISEASES |
| title_sort | to the problem of experimental morphological studies of radiation induced thyroid diseases |
| topic | thyroid cancer gamma radiation acute radiation-induced disease histomorphometry papillary cancer |
| url | https://www.siboncoj.ru/jour/article/view/251 |
| work_keys_str_mv | AT yumiryanov totheproblemofexperimentalmorphologicalstudiesofradiationinducedthyroiddiseases AT gnfilimonova totheproblemofexperimentalmorphologicalstudiesofradiationinducedthyroiddiseases |