Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity
A series of Compound 4-(2᾽-hydroxy-3᾽-chloro-5᾽-ethyl phen-1᾽-yl)-1-(4᾽-tolyl)-3-chloro-2-azetidinone 4a-j have been prepared by the reaction of 2 -hydroxy-3 -chloro-5 -ethyl-N-(p-tolyl)-chalconimines 3a-j with chloroacetyl chloride in the presence of triethylamine. The Schiff base derivatives 3a-j...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2004-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2004/158924 |
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| _version_ | 1849409150516199424 |
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| author | Kamal Vashi H. B. Naik |
| author_facet | Kamal Vashi H. B. Naik |
| author_sort | Kamal Vashi |
| collection | DOAJ |
| description | A series of Compound 4-(2᾽-hydroxy-3᾽-chloro-5᾽-ethyl phen-1᾽-yl)-1-(4᾽-tolyl)-3-chloro-2-azetidinone 4a-j have been prepared by the reaction of 2 -hydroxy-3 -chloro-5 -ethyl-N-(p-tolyl)-chalconimines 3a-j with chloroacetyl chloride in the presence of triethylamine. The Schiff base derivatives 3a-j has been prepared by the condensation of different substituted chalone derivatives 1 with p-toluidine 2. The synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus and Escherichia coli. |
| format | Article |
| id | doaj-art-77f37d2e6add484a9b28f7ea890d477f |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-77f37d2e6add484a9b28f7ea890d477f2025-08-20T03:35:36ZengWileyE-Journal of Chemistry0973-49452090-98102004-01-011527227510.1155/2004/158924Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial ActivityKamal Vashi0H. B. Naik1Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, IndiaDepartment of Chemistry, Veer Narmad South Gujarat University, Surat 395007, IndiaA series of Compound 4-(2᾽-hydroxy-3᾽-chloro-5᾽-ethyl phen-1᾽-yl)-1-(4᾽-tolyl)-3-chloro-2-azetidinone 4a-j have been prepared by the reaction of 2 -hydroxy-3 -chloro-5 -ethyl-N-(p-tolyl)-chalconimines 3a-j with chloroacetyl chloride in the presence of triethylamine. The Schiff base derivatives 3a-j has been prepared by the condensation of different substituted chalone derivatives 1 with p-toluidine 2. The synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus and Escherichia coli.http://dx.doi.org/10.1155/2004/158924 |
| spellingShingle | Kamal Vashi H. B. Naik Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity E-Journal of Chemistry |
| title | Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity |
| title_full | Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity |
| title_fullStr | Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity |
| title_full_unstemmed | Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity |
| title_short | Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity |
| title_sort | synthesis of novel schiff base and azetidinone derivatives and their antibacterial activity |
| url | http://dx.doi.org/10.1155/2004/158924 |
| work_keys_str_mv | AT kamalvashi synthesisofnovelschiffbaseandazetidinonederivativesandtheirantibacterialactivity AT hbnaik synthesisofnovelschiffbaseandazetidinonederivativesandtheirantibacterialactivity |