Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity
A series of Compound 4-(2᾽-hydroxy-3᾽-chloro-5᾽-ethyl phen-1᾽-yl)-1-(4᾽-tolyl)-3-chloro-2-azetidinone 4a-j have been prepared by the reaction of 2 -hydroxy-3 -chloro-5 -ethyl-N-(p-tolyl)-chalconimines 3a-j with chloroacetyl chloride in the presence of triethylamine. The Schiff base derivatives 3a-j...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2004-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2004/158924 |
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| Summary: | A series of Compound 4-(2᾽-hydroxy-3᾽-chloro-5᾽-ethyl phen-1᾽-yl)-1-(4᾽-tolyl)-3-chloro-2-azetidinone 4a-j have been prepared by the reaction of 2 -hydroxy-3 -chloro-5 -ethyl-N-(p-tolyl)-chalconimines 3a-j with chloroacetyl chloride in the presence of triethylamine. The Schiff base derivatives 3a-j has been prepared by the condensation of different substituted chalone derivatives 1 with p-toluidine 2. The synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus and Escherichia coli. |
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| ISSN: | 0973-4945 2090-9810 |