Antimicrobial Activity of Thermocycled Polymethyl Methacrylate Resin Reinforced with Titanium Dioxide and Copper Oxide Nanoparticles
Aims. This study aimed to evaluate the effect of 2.5% and 7.5% copper oxide (CuO) and titanium dioxide (TiO2) nanoparticles on the antimicrobial activity of thermocycled polymethyl methacrylate (PMMA) denture base material against standard strains of yeast and bacteria species. Material and Methods....
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2021/6690806 |
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| author | Rashin Giti Kamiar Zomorodian Maryam Firouzmandi Zahra Zareshahrabadi Sedigheh Rahmannasab |
| author_facet | Rashin Giti Kamiar Zomorodian Maryam Firouzmandi Zahra Zareshahrabadi Sedigheh Rahmannasab |
| author_sort | Rashin Giti |
| collection | DOAJ |
| description | Aims. This study aimed to evaluate the effect of 2.5% and 7.5% copper oxide (CuO) and titanium dioxide (TiO2) nanoparticles on the antimicrobial activity of thermocycled polymethyl methacrylate (PMMA) denture base material against standard strains of yeast and bacteria species. Material and Methods. In this in vitro study, 150 disk-shaped (10 × 2 mm) specimens of heat-cured PMMA were prepared and divided into five groups (n = 30) to be reinforced with 2.5% CuO, 7.5% CuO, 2.5% TiO2, or 7.5% TiO2 nanoparticles and a control group (without nanoparticle). The specimens were thermocycled, and their antimicrobial activity was assessed against standard strains of yeast including Candida albicans and C. dubliniensis and oral bacteria species including Streptococcus mutans, S. sobrinus, S. salivarius, and S. sanguis. Data were analyzed with ANOVA and Tukey’s post hoc tests (α = 0.05). Results. Both concentrations of CuO and TiO2 nanoparticles had significant antimicrobial activity against S. salivarius, S. sanguis, and C. dubliniensis compared with the control group (P < 0.05). Significant differences existed between both 2.5% (P = 0.006) and 7.5% CuO (P = 0.005) and the control group against S. mutans. However, TiO2 groups were not significantly different from the control group against S. mutans. Concerning C. albicans, 7.5% TiO2 was the only nanoparticle with significantly higher antimicrobial activity compared with the control group (P = 0.043). Conclusions. Both concentrations of CuO and TiO2 were effective antimicrobial agents against S. salivarius, S. sanguis, and C. dubliniensis, and the concentration of CuO was effective against S. mutans. Yet, TiO2 was not much effective. Regarding C. albicans, only 7.5% TiO2 showed efficient antimicrobial activity. |
| format | Article |
| id | doaj-art-77f044450b8d4ac1b6725d0b050a2b69 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-77f044450b8d4ac1b6725d0b050a2b692025-02-03T05:49:15ZengWileyInternational Journal of Dentistry1687-87281687-87362021-01-01202110.1155/2021/66908066690806Antimicrobial Activity of Thermocycled Polymethyl Methacrylate Resin Reinforced with Titanium Dioxide and Copper Oxide NanoparticlesRashin Giti0Kamiar Zomorodian1Maryam Firouzmandi2Zahra Zareshahrabadi3Sedigheh Rahmannasab4Department of Prosthodontics, Biomaterials Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IranBasic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Operative Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Medical Mycology and Parasitology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IranAims. This study aimed to evaluate the effect of 2.5% and 7.5% copper oxide (CuO) and titanium dioxide (TiO2) nanoparticles on the antimicrobial activity of thermocycled polymethyl methacrylate (PMMA) denture base material against standard strains of yeast and bacteria species. Material and Methods. In this in vitro study, 150 disk-shaped (10 × 2 mm) specimens of heat-cured PMMA were prepared and divided into five groups (n = 30) to be reinforced with 2.5% CuO, 7.5% CuO, 2.5% TiO2, or 7.5% TiO2 nanoparticles and a control group (without nanoparticle). The specimens were thermocycled, and their antimicrobial activity was assessed against standard strains of yeast including Candida albicans and C. dubliniensis and oral bacteria species including Streptococcus mutans, S. sobrinus, S. salivarius, and S. sanguis. Data were analyzed with ANOVA and Tukey’s post hoc tests (α = 0.05). Results. Both concentrations of CuO and TiO2 nanoparticles had significant antimicrobial activity against S. salivarius, S. sanguis, and C. dubliniensis compared with the control group (P < 0.05). Significant differences existed between both 2.5% (P = 0.006) and 7.5% CuO (P = 0.005) and the control group against S. mutans. However, TiO2 groups were not significantly different from the control group against S. mutans. Concerning C. albicans, 7.5% TiO2 was the only nanoparticle with significantly higher antimicrobial activity compared with the control group (P = 0.043). Conclusions. Both concentrations of CuO and TiO2 were effective antimicrobial agents against S. salivarius, S. sanguis, and C. dubliniensis, and the concentration of CuO was effective against S. mutans. Yet, TiO2 was not much effective. Regarding C. albicans, only 7.5% TiO2 showed efficient antimicrobial activity.http://dx.doi.org/10.1155/2021/6690806 |
| spellingShingle | Rashin Giti Kamiar Zomorodian Maryam Firouzmandi Zahra Zareshahrabadi Sedigheh Rahmannasab Antimicrobial Activity of Thermocycled Polymethyl Methacrylate Resin Reinforced with Titanium Dioxide and Copper Oxide Nanoparticles International Journal of Dentistry |
| title | Antimicrobial Activity of Thermocycled Polymethyl Methacrylate Resin Reinforced with Titanium Dioxide and Copper Oxide Nanoparticles |
| title_full | Antimicrobial Activity of Thermocycled Polymethyl Methacrylate Resin Reinforced with Titanium Dioxide and Copper Oxide Nanoparticles |
| title_fullStr | Antimicrobial Activity of Thermocycled Polymethyl Methacrylate Resin Reinforced with Titanium Dioxide and Copper Oxide Nanoparticles |
| title_full_unstemmed | Antimicrobial Activity of Thermocycled Polymethyl Methacrylate Resin Reinforced with Titanium Dioxide and Copper Oxide Nanoparticles |
| title_short | Antimicrobial Activity of Thermocycled Polymethyl Methacrylate Resin Reinforced with Titanium Dioxide and Copper Oxide Nanoparticles |
| title_sort | antimicrobial activity of thermocycled polymethyl methacrylate resin reinforced with titanium dioxide and copper oxide nanoparticles |
| url | http://dx.doi.org/10.1155/2021/6690806 |
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