Low expression of CADPS predicts poor prognosis in pediatric acute lymphoblastic leukemia without fusion genes
Pediatric acute lymphoblastic leukemia (ALL) is among the most prevalent hematological malignancies in children. Despite an overall cure rate approaching 90%, a subset of patients still experiences relapse, even with advanced therapeutic interventions. Research into the molecular characteristics an...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2025-05-01
|
| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/12254 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850111277239631872 |
|---|---|
| author | Bin Zhang Chaoran Shi Xiuxiu Wang Jiajia Mi Runan Wang Shuang Li Jiawei Yang Qiuying He Yujiao Wang Zuofei Chi Liangchun Hao |
| author_facet | Bin Zhang Chaoran Shi Xiuxiu Wang Jiajia Mi Runan Wang Shuang Li Jiawei Yang Qiuying He Yujiao Wang Zuofei Chi Liangchun Hao |
| author_sort | Bin Zhang |
| collection | DOAJ |
| description |
Pediatric acute lymphoblastic leukemia (ALL) is among the most prevalent hematological malignancies in children. Despite an overall cure rate approaching 90%, a subset of patients still experiences relapse, even with advanced therapeutic interventions. Research into the molecular characteristics and prognostic markers of fusion gene-negative (FG-negative) pediatric ALL remains limited. To address this gap, we performed whole-exome sequencing (WES) and whole-transcriptome sequencing (RNA-seq) on 54 FG-negative ALL cases from our center. Our results indicated that neither specific mutations nor tumor mutational burden significantly influenced relapse risk. Notably, we identified a significant downregulation of CADPS in FG-negative pediatric ALL patients who relapsed. The expression levels and prognostic significance of CADPS were further validated using data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) cohort, where lower CADPS expression was associated with reduced event-free survival (EFS) and overall survival (OS) (P < 0.001 for both). Cox regression analyses were subsequently employed to identify OS-related factors and to construct a prognostic prediction model. Notably, this model demonstrated a significant correlation with therapeutic targets. In conclusion, our findings support the potential of CADPS expression as a novel biomarker for prognostic stratification in FG-negative pediatric ALL patients.
|
| format | Article |
| id | doaj-art-77f03a9c9cef4e6e80637bdc8516163c |
| institution | OA Journals |
| issn | 2831-0896 2831-090X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj-art-77f03a9c9cef4e6e80637bdc8516163c2025-08-20T02:37:39ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2025-05-0110.17305/bb.2025.12254Low expression of CADPS predicts poor prognosis in pediatric acute lymphoblastic leukemia without fusion genesBin Zhang0Chaoran Shi1Xiuxiu Wang2Jiajia Mi3Runan Wang4Shuang Li5Jiawei Yang6Qiuying He7Yujiao Wang8Zuofei Chi9Liangchun Hao10Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Translational Medicine Center, Chigene (Beijing) Translational Medical Research Center Co., Beijing, ChinaDepartment of Translational Medicine Center, Chigene (Beijing) Translational Medical Research Center Co., Beijing, ChinaDepartment of Translational Medicine Center, Chigene (Beijing) Translational Medical Research Center Co., Beijing, ChinaDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China Pediatric acute lymphoblastic leukemia (ALL) is among the most prevalent hematological malignancies in children. Despite an overall cure rate approaching 90%, a subset of patients still experiences relapse, even with advanced therapeutic interventions. Research into the molecular characteristics and prognostic markers of fusion gene-negative (FG-negative) pediatric ALL remains limited. To address this gap, we performed whole-exome sequencing (WES) and whole-transcriptome sequencing (RNA-seq) on 54 FG-negative ALL cases from our center. Our results indicated that neither specific mutations nor tumor mutational burden significantly influenced relapse risk. Notably, we identified a significant downregulation of CADPS in FG-negative pediatric ALL patients who relapsed. The expression levels and prognostic significance of CADPS were further validated using data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) cohort, where lower CADPS expression was associated with reduced event-free survival (EFS) and overall survival (OS) (P < 0.001 for both). Cox regression analyses were subsequently employed to identify OS-related factors and to construct a prognostic prediction model. Notably, this model demonstrated a significant correlation with therapeutic targets. In conclusion, our findings support the potential of CADPS expression as a novel biomarker for prognostic stratification in FG-negative pediatric ALL patients. https://www.bjbms.org/ojs/index.php/bjbms/article/view/12254Pediatric acute lymphoblastic leukemiaALLfusion gene negativeFG-negativenext-generation sequencingprognostic biomarker |
| spellingShingle | Bin Zhang Chaoran Shi Xiuxiu Wang Jiajia Mi Runan Wang Shuang Li Jiawei Yang Qiuying He Yujiao Wang Zuofei Chi Liangchun Hao Low expression of CADPS predicts poor prognosis in pediatric acute lymphoblastic leukemia without fusion genes Biomolecules & Biomedicine Pediatric acute lymphoblastic leukemia ALL fusion gene negative FG-negative next-generation sequencing prognostic biomarker |
| title | Low expression of CADPS predicts poor prognosis in pediatric acute lymphoblastic leukemia without fusion genes |
| title_full | Low expression of CADPS predicts poor prognosis in pediatric acute lymphoblastic leukemia without fusion genes |
| title_fullStr | Low expression of CADPS predicts poor prognosis in pediatric acute lymphoblastic leukemia without fusion genes |
| title_full_unstemmed | Low expression of CADPS predicts poor prognosis in pediatric acute lymphoblastic leukemia without fusion genes |
| title_short | Low expression of CADPS predicts poor prognosis in pediatric acute lymphoblastic leukemia without fusion genes |
| title_sort | low expression of cadps predicts poor prognosis in pediatric acute lymphoblastic leukemia without fusion genes |
| topic | Pediatric acute lymphoblastic leukemia ALL fusion gene negative FG-negative next-generation sequencing prognostic biomarker |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/12254 |
| work_keys_str_mv | AT binzhang lowexpressionofcadpspredictspoorprognosisinpediatricacutelymphoblasticleukemiawithoutfusiongenes AT chaoranshi lowexpressionofcadpspredictspoorprognosisinpediatricacutelymphoblasticleukemiawithoutfusiongenes AT xiuxiuwang lowexpressionofcadpspredictspoorprognosisinpediatricacutelymphoblasticleukemiawithoutfusiongenes AT jiajiami lowexpressionofcadpspredictspoorprognosisinpediatricacutelymphoblasticleukemiawithoutfusiongenes AT runanwang lowexpressionofcadpspredictspoorprognosisinpediatricacutelymphoblasticleukemiawithoutfusiongenes AT shuangli lowexpressionofcadpspredictspoorprognosisinpediatricacutelymphoblasticleukemiawithoutfusiongenes AT jiaweiyang lowexpressionofcadpspredictspoorprognosisinpediatricacutelymphoblasticleukemiawithoutfusiongenes AT qiuyinghe lowexpressionofcadpspredictspoorprognosisinpediatricacutelymphoblasticleukemiawithoutfusiongenes AT yujiaowang lowexpressionofcadpspredictspoorprognosisinpediatricacutelymphoblasticleukemiawithoutfusiongenes AT zuofeichi lowexpressionofcadpspredictspoorprognosisinpediatricacutelymphoblasticleukemiawithoutfusiongenes AT liangchunhao lowexpressionofcadpspredictspoorprognosisinpediatricacutelymphoblasticleukemiawithoutfusiongenes |