Chronic Lymphocytic Leukemia with Translocation (2;14)(p16;q32): A Case Report and Review of the Literature
We report the case of a young African American male with no significant past medical history presenting with low back and bilateral leg pain; presenting CBC and chemistries revealed elevated white blood cell count of 250,000, with anemia (Hb 6.8 g/dL) and thrombocytopenia (platelets 9 K/μL), and ele...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/9037436 |
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| author | Francisco Socola Giovanni Insuasti-Beltran Rodolfo Henrich Lobo Shebli Atrash Appalanaidu Sasapu |
| author_facet | Francisco Socola Giovanni Insuasti-Beltran Rodolfo Henrich Lobo Shebli Atrash Appalanaidu Sasapu |
| author_sort | Francisco Socola |
| collection | DOAJ |
| description | We report the case of a young African American male with no significant past medical history presenting with low back and bilateral leg pain; presenting CBC and chemistries revealed elevated white blood cell count of 250,000, with anemia (Hb 6.8 g/dL) and thrombocytopenia (platelets 9 K/μL), and elevated LDH, 1008. Physical examination findings were notable for diffuse lymphadenopathy and lower extremity skin nodules. Interestingly the bone marrow biopsy revealed involvement by CLL/SLL with translocation (2;14)(p16;q32) and trisomy 12. The patient was treated with fludarabine-based chemotherapy and steroids for CLL-related ITP with excellent response. After three cycles of chemotherapy, all the enlarged lymph nodes and skin nodules disappeared, and patient had achieved complete hematologic response. In this paper we also reviewed the available literature of CLL patients with translocation (2;14). |
| format | Article |
| id | doaj-art-77edf553402b4665aa587afb0f0ace6f |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-77edf553402b4665aa587afb0f0ace6f2025-08-20T03:35:38ZengWileyCase Reports in Oncological Medicine2090-67062090-67142016-01-01201610.1155/2016/90374369037436Chronic Lymphocytic Leukemia with Translocation (2;14)(p16;q32): A Case Report and Review of the LiteratureFrancisco Socola0Giovanni Insuasti-Beltran1Rodolfo Henrich Lobo2Shebli Atrash3Appalanaidu Sasapu4Department of Medicine, Division of Hematology Oncology, University of Arkansas for Medical Science, Little Rock, AR, USADepartment of Hematopathology/Molecular Genetics Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USADepartment of Hematopathology/Molecular Genetics Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USADepartment of Medicine, Division of Hematology Oncology, University of Arkansas for Medical Science, Little Rock, AR, USADepartment of Medicine, Division of Hematology Oncology, University of Arkansas for Medical Science, Little Rock, AR, USAWe report the case of a young African American male with no significant past medical history presenting with low back and bilateral leg pain; presenting CBC and chemistries revealed elevated white blood cell count of 250,000, with anemia (Hb 6.8 g/dL) and thrombocytopenia (platelets 9 K/μL), and elevated LDH, 1008. Physical examination findings were notable for diffuse lymphadenopathy and lower extremity skin nodules. Interestingly the bone marrow biopsy revealed involvement by CLL/SLL with translocation (2;14)(p16;q32) and trisomy 12. The patient was treated with fludarabine-based chemotherapy and steroids for CLL-related ITP with excellent response. After three cycles of chemotherapy, all the enlarged lymph nodes and skin nodules disappeared, and patient had achieved complete hematologic response. In this paper we also reviewed the available literature of CLL patients with translocation (2;14).http://dx.doi.org/10.1155/2016/9037436 |
| spellingShingle | Francisco Socola Giovanni Insuasti-Beltran Rodolfo Henrich Lobo Shebli Atrash Appalanaidu Sasapu Chronic Lymphocytic Leukemia with Translocation (2;14)(p16;q32): A Case Report and Review of the Literature Case Reports in Oncological Medicine |
| title | Chronic Lymphocytic Leukemia with Translocation (2;14)(p16;q32): A Case Report and Review of the Literature |
| title_full | Chronic Lymphocytic Leukemia with Translocation (2;14)(p16;q32): A Case Report and Review of the Literature |
| title_fullStr | Chronic Lymphocytic Leukemia with Translocation (2;14)(p16;q32): A Case Report and Review of the Literature |
| title_full_unstemmed | Chronic Lymphocytic Leukemia with Translocation (2;14)(p16;q32): A Case Report and Review of the Literature |
| title_short | Chronic Lymphocytic Leukemia with Translocation (2;14)(p16;q32): A Case Report and Review of the Literature |
| title_sort | chronic lymphocytic leukemia with translocation 2 14 p16 q32 a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2016/9037436 |
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