Relationship Between Cognitive Impairment and Quality of Life in Systemic Lupus Erythematosus: A Multimodal Neuroimaging Perspective
Qiuping Liu, Min Liu, Qinghua Zou Department of Rheumatology and Immunology, First Affiliated Hospital of Army Medical University, Chongqing, 400038, People’s Republic of ChinaCorrespondence: Qinghua Zou, Email zouqinghua318@tmmu.edu.cnAbstract: Systemic lupus erythematosus (SLE) is a chronic inflam...
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Dove Medical Press
2025-08-01
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| Series: | International Journal of General Medicine |
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| author | Liu Q Liu M Zou Q |
| author_facet | Liu Q Liu M Zou Q |
| author_sort | Liu Q |
| collection | DOAJ |
| description | Qiuping Liu, Min Liu, Qinghua Zou Department of Rheumatology and Immunology, First Affiliated Hospital of Army Medical University, Chongqing, 400038, People’s Republic of ChinaCorrespondence: Qinghua Zou, Email zouqinghua318@tmmu.edu.cnAbstract: Systemic lupus erythematosus (SLE) is a chronic inflammatory multi-system disorder that affects both central and peripheral nervous systems, leading to diverse neuropsychiatric manifestations. Cognitive impairment represents one of the most prevalent and debilitating neuropsychiatric symptoms in SLE, occurring in up to 80% of patients, with significant long-term clinical consequences. Despite its high prevalence, the underlying pathogenesis remains unclear, and its insidious onset and variable presentation often lead to underdiagnosis in clinical practice. Multimodal MRI techniques offer valuable insights into structural, functional, and metabolic abnormalities across both localized brain regions and global neural networks, facilitating comprehensive assessment of SLE-related cognitive dysfunction. Recent advances in SLE management have emphasized patient quality of life (QoL), and multimodal neuroimaging approaches may elucidate the relationship between cognitive impairment and QoL deterioration. Such strategies could improve early detection, therapeutic intervention, and preventive measures, ultimately enhancing socioeconomic outcomes and QoL for SLE patients with cognitive impairment.Keywords: systemic lupus erythematosus, cognitive impairment, multimodal magnetic resonance imaging, quality of life |
| format | Article |
| id | doaj-art-77eaef4023d84c7bb9355c08e9b9d8eb |
| institution | DOAJ |
| issn | 1178-7074 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj-art-77eaef4023d84c7bb9355c08e9b9d8eb2025-08-20T02:58:18ZengDove Medical PressInternational Journal of General Medicine1178-70742025-08-01Volume 18Issue 143274336105570Relationship Between Cognitive Impairment and Quality of Life in Systemic Lupus Erythematosus: A Multimodal Neuroimaging PerspectiveLiu Q0Liu M1Zou Q2Department of Rheumatology and ImmunologyDepartment of Rheumatology and ImmunologDepartment of Rheumatology and ImmunologyQiuping Liu, Min Liu, Qinghua Zou Department of Rheumatology and Immunology, First Affiliated Hospital of Army Medical University, Chongqing, 400038, People’s Republic of ChinaCorrespondence: Qinghua Zou, Email zouqinghua318@tmmu.edu.cnAbstract: Systemic lupus erythematosus (SLE) is a chronic inflammatory multi-system disorder that affects both central and peripheral nervous systems, leading to diverse neuropsychiatric manifestations. Cognitive impairment represents one of the most prevalent and debilitating neuropsychiatric symptoms in SLE, occurring in up to 80% of patients, with significant long-term clinical consequences. Despite its high prevalence, the underlying pathogenesis remains unclear, and its insidious onset and variable presentation often lead to underdiagnosis in clinical practice. Multimodal MRI techniques offer valuable insights into structural, functional, and metabolic abnormalities across both localized brain regions and global neural networks, facilitating comprehensive assessment of SLE-related cognitive dysfunction. Recent advances in SLE management have emphasized patient quality of life (QoL), and multimodal neuroimaging approaches may elucidate the relationship between cognitive impairment and QoL deterioration. Such strategies could improve early detection, therapeutic intervention, and preventive measures, ultimately enhancing socioeconomic outcomes and QoL for SLE patients with cognitive impairment.Keywords: systemic lupus erythematosus, cognitive impairment, multimodal magnetic resonance imaging, quality of lifehttps://www.dovepress.com/relationship-between-cognitive-impairment-and-quality-of-life-in-syste-peer-reviewed-fulltext-article-IJGMsystemic lupus erythematosuscognitive impairmentmultimodal magnetic resonance imagingquality of life |
| spellingShingle | Liu Q Liu M Zou Q Relationship Between Cognitive Impairment and Quality of Life in Systemic Lupus Erythematosus: A Multimodal Neuroimaging Perspective International Journal of General Medicine systemic lupus erythematosus cognitive impairment multimodal magnetic resonance imaging quality of life |
| title | Relationship Between Cognitive Impairment and Quality of Life in Systemic Lupus Erythematosus: A Multimodal Neuroimaging Perspective |
| title_full | Relationship Between Cognitive Impairment and Quality of Life in Systemic Lupus Erythematosus: A Multimodal Neuroimaging Perspective |
| title_fullStr | Relationship Between Cognitive Impairment and Quality of Life in Systemic Lupus Erythematosus: A Multimodal Neuroimaging Perspective |
| title_full_unstemmed | Relationship Between Cognitive Impairment and Quality of Life in Systemic Lupus Erythematosus: A Multimodal Neuroimaging Perspective |
| title_short | Relationship Between Cognitive Impairment and Quality of Life in Systemic Lupus Erythematosus: A Multimodal Neuroimaging Perspective |
| title_sort | relationship between cognitive impairment and quality of life in systemic lupus erythematosus a multimodal neuroimaging perspective |
| topic | systemic lupus erythematosus cognitive impairment multimodal magnetic resonance imaging quality of life |
| url | https://www.dovepress.com/relationship-between-cognitive-impairment-and-quality-of-life-in-syste-peer-reviewed-fulltext-article-IJGM |
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