Noninvasive markers of inflammatory bowel disease activity
Aim of investigation. To study noninvasive activity markers of inflammatory bowel diseases (IBD) and to estimate correlation between various diagnostic methods for an assessment of clinical and endoscopical activity of ulcerative colitis (UC) and Crohn's disease (CD). Material and methods. Orig...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2018-08-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/101 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860290604761088 |
|---|---|
| author | A. V. Nikitin L. V. Vasilyeva Anatoly A. Matiukhin |
| author_facet | A. V. Nikitin L. V. Vasilyeva Anatoly A. Matiukhin |
| author_sort | A. V. Nikitin |
| collection | DOAJ |
| description | Aim of investigation. To study noninvasive activity markers of inflammatory bowel diseases (IBD) and to estimate correlation between various diagnostic methods for an assessment of clinical and endoscopical activity of ulcerative colitis (UC) and Crohn's disease (CD). Material and methods. Original study included 67 patients with UC and CD in whom clinical and endoscopic activity of the disease with assessed by histological investigation of biopsy specimens. Blood serum cytokines: IL-4, IL-8, tumor necrosis factor α (TNF-α) and fecal calcium binding protein (calprotectin) were assessed. Results. Fecal calprotectin and TNF-α levels were much higher in patients with high disease activity and extent of inflammatory process. Spearman correlation coefficient between endoscopic features and fecal calprotectin (0,82) was higher in the UC patients, than between endoscopic parameters and TNF-α (0,78) in CD patients. Conclusions. Noninvasive inflammatory activity markers should be taken into account and decision-making on diagnostic and treatment strategy, as well as to decrease expensive and invasive diagnostic procedures. |
| format | Article |
| id | doaj-art-77e995462c014dccbee0b494a43cce8e |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-77e995462c014dccbee0b494a43cce8e2025-02-10T16:14:29ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-0126610611110.22416/1382-4376-2016-6-106-111101Noninvasive markers of inflammatory bowel disease activityA. V. Nikitin0L. V. Vasilyeva1Anatoly A. Matiukhin2State educational state-funded institution of higher professional education «Burdenko Voronezh state medical academy»; Voronezh regional hospital No. 1State educational state-funded institution of higher professional education «Burdenko Voronezh state medical academy»; Voronezh regional hospital No. 1State educational state-funded institution of higher professional education «Burdenko Voronezh state medical academy»; Voronezh regional hospital No. 1Aim of investigation. To study noninvasive activity markers of inflammatory bowel diseases (IBD) and to estimate correlation between various diagnostic methods for an assessment of clinical and endoscopical activity of ulcerative colitis (UC) and Crohn's disease (CD). Material and methods. Original study included 67 patients with UC and CD in whom clinical and endoscopic activity of the disease with assessed by histological investigation of biopsy specimens. Blood serum cytokines: IL-4, IL-8, tumor necrosis factor α (TNF-α) and fecal calcium binding protein (calprotectin) were assessed. Results. Fecal calprotectin and TNF-α levels were much higher in patients with high disease activity and extent of inflammatory process. Spearman correlation coefficient between endoscopic features and fecal calprotectin (0,82) was higher in the UC patients, than between endoscopic parameters and TNF-α (0,78) in CD patients. Conclusions. Noninvasive inflammatory activity markers should be taken into account and decision-making on diagnostic and treatment strategy, as well as to decrease expensive and invasive diagnostic procedures.https://www.gastro-j.ru/jour/article/view/101воспалительные заболевания кишечникаязвенный колитболезнь кронаинтерлейкиныкальпротектин |
| spellingShingle | A. V. Nikitin L. V. Vasilyeva Anatoly A. Matiukhin Noninvasive markers of inflammatory bowel disease activity Российский журнал гастроэнтерологии, гепатологии, колопроктологии воспалительные заболевания кишечника язвенный колит болезнь крона интерлейкины кальпротектин |
| title | Noninvasive markers of inflammatory bowel disease activity |
| title_full | Noninvasive markers of inflammatory bowel disease activity |
| title_fullStr | Noninvasive markers of inflammatory bowel disease activity |
| title_full_unstemmed | Noninvasive markers of inflammatory bowel disease activity |
| title_short | Noninvasive markers of inflammatory bowel disease activity |
| title_sort | noninvasive markers of inflammatory bowel disease activity |
| topic | воспалительные заболевания кишечника язвенный колит болезнь крона интерлейкины кальпротектин |
| url | https://www.gastro-j.ru/jour/article/view/101 |
| work_keys_str_mv | AT avnikitin noninvasivemarkersofinflammatoryboweldiseaseactivity AT lvvasilyeva noninvasivemarkersofinflammatoryboweldiseaseactivity AT anatolyamatiukhin noninvasivemarkersofinflammatoryboweldiseaseactivity |