Herpes Simplex Virus-2 Esophagitis in a Young Immunocompetent Adult

Herpes simplex esophagitis (HSE) is commonly identified in immunosuppressed patients. It is rare among immunocompetent patients and almost all of the reported cases are due to HSV-1 infection. HSV-2 esophagitis is extremely rare. We report the case of a young immunocompetent male who presented with...

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Main Authors: Deepak K. Kadayakkara, Angela Candelaria, Ye Eun Kwak, Caroline Loeser
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Case Reports in Gastrointestinal Medicine
Online Access:http://dx.doi.org/10.1155/2016/7603484
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author Deepak K. Kadayakkara
Angela Candelaria
Ye Eun Kwak
Caroline Loeser
author_facet Deepak K. Kadayakkara
Angela Candelaria
Ye Eun Kwak
Caroline Loeser
author_sort Deepak K. Kadayakkara
collection DOAJ
description Herpes simplex esophagitis (HSE) is commonly identified in immunosuppressed patients. It is rare among immunocompetent patients and almost all of the reported cases are due to HSV-1 infection. HSV-2 esophagitis is extremely rare. We report the case of a young immunocompetent male who presented with dysphagia, odynophagia, and epigastric pain. Endoscopy showed multitudes of white nummular lesions in the distal esophagus initially suspected to be candida esophagitis. However, classic histopathological findings of multinucleated giant cells with eosinophilic intranuclear inclusions and positive HSV-2 IgM confirmed the diagnosis of HSV-2 esophagitis. The patient rapidly responded to acyclovir treatment. Although HSV-2 is predominantly associated with genital herpes, it can cause infections in other parts of the body previously attributed to only HSV-1 infection.
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spelling doaj-art-77e7bf1389724d2eb004cb8805196b702025-08-20T02:07:09ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362016-01-01201610.1155/2016/76034847603484Herpes Simplex Virus-2 Esophagitis in a Young Immunocompetent AdultDeepak K. Kadayakkara0Angela Candelaria1Ye Eun Kwak2Caroline Loeser3Department of Medicine, Bridgeport Hospital-Yale New Haven Health, Bridgeport, CT 06610, USADepartment of Medicine, Bridgeport Hospital-Yale New Haven Health, Bridgeport, CT 06610, USADepartment of Medicine, Bridgeport Hospital-Yale New Haven Health, Bridgeport, CT 06610, USADepartment of Medicine, Bridgeport Hospital-Yale New Haven Health, Bridgeport, CT 06610, USAHerpes simplex esophagitis (HSE) is commonly identified in immunosuppressed patients. It is rare among immunocompetent patients and almost all of the reported cases are due to HSV-1 infection. HSV-2 esophagitis is extremely rare. We report the case of a young immunocompetent male who presented with dysphagia, odynophagia, and epigastric pain. Endoscopy showed multitudes of white nummular lesions in the distal esophagus initially suspected to be candida esophagitis. However, classic histopathological findings of multinucleated giant cells with eosinophilic intranuclear inclusions and positive HSV-2 IgM confirmed the diagnosis of HSV-2 esophagitis. The patient rapidly responded to acyclovir treatment. Although HSV-2 is predominantly associated with genital herpes, it can cause infections in other parts of the body previously attributed to only HSV-1 infection.http://dx.doi.org/10.1155/2016/7603484
spellingShingle Deepak K. Kadayakkara
Angela Candelaria
Ye Eun Kwak
Caroline Loeser
Herpes Simplex Virus-2 Esophagitis in a Young Immunocompetent Adult
Case Reports in Gastrointestinal Medicine
title Herpes Simplex Virus-2 Esophagitis in a Young Immunocompetent Adult
title_full Herpes Simplex Virus-2 Esophagitis in a Young Immunocompetent Adult
title_fullStr Herpes Simplex Virus-2 Esophagitis in a Young Immunocompetent Adult
title_full_unstemmed Herpes Simplex Virus-2 Esophagitis in a Young Immunocompetent Adult
title_short Herpes Simplex Virus-2 Esophagitis in a Young Immunocompetent Adult
title_sort herpes simplex virus 2 esophagitis in a young immunocompetent adult
url http://dx.doi.org/10.1155/2016/7603484
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