FEATURES OF THE IMMUNE RESPONSE AND EFFICACY IMMUNOTHERAPY FOR ROTAVIRUS INFECTION IN CHILDREN
The article reflects the changes in both cellular and humoral immunity in rotavirus infection, as well as the correlation between the degree of severity of immunological disorders and the peculiarities of the clinical course of the disease in childhood. The most significant changes in cytokine stat...
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| Format: | Article |
| Language: | Russian |
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LLC "Diagnostics and Vaccines"
2018-09-01
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| Series: | Детские инфекции (Москва) |
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| Online Access: | https://detinf.elpub.ru/jour/article/view/375 |
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| author | S. G. Gorbunov L. N. Mazankova I. D. Maykova O. I. Demina E. P. Koval |
| author_facet | S. G. Gorbunov L. N. Mazankova I. D. Maykova O. I. Demina E. P. Koval |
| author_sort | S. G. Gorbunov |
| collection | DOAJ |
| description | The article reflects the changes in both cellular and humoral immunity in rotavirus infection, as well as the correlation between the degree of severity of immunological disorders and the peculiarities of the clinical course of the disease in childhood. The most significant changes in cytokine status are associated with an increase in interleukin-1b, which is a marker of intoxication. In addition, during rotavirus infection in children reduced the level of induced interferon a and у, that justified the application of a2b-interferon that is part of the drug VIFERON®, containing also vitamins E and C. The appointment of drug VIFERON®, along with basic therapy, including the probiotic strains LGG and ВВ12 in the complex of therapeutic measures in children with rotavirus infection allows to improve the dynamics of clinical and immunological indicators, as well as to reduce 1.5 times the number of cases of ARI within 6 months of the follow-up observations after the acute period of the disease. |
| format | Article |
| id | doaj-art-77e1b8ea73c14655a2fd83105c551c25 |
| institution | DOAJ |
| issn | 2072-8107 |
| language | Russian |
| publishDate | 2018-09-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj-art-77e1b8ea73c14655a2fd83105c551c252025-08-20T02:46:33ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072018-09-01173384610.22627/2072-8107-2018-17-3-38-46351FEATURES OF THE IMMUNE RESPONSE AND EFFICACY IMMUNOTHERAPY FOR ROTAVIRUS INFECTION IN CHILDRENS. G. Gorbunov0L. N. Mazankova1I. D. Maykova2O. I. Demina3E. P. Koval4Russian Medical Academy of Continuig Professional Education of the Ministry of Healthcare of the Russian FederationRussian Medical Academy of Continuig Professional Education of the Ministry of Healthcare of the Russian FederationСhildren's city clinical hospital named after Z.A. Bashlyayeva of Moscow Department of HealthcareRussian Medical Academy of Continuig Professional Education of the Ministry of Healthcare of the Russian FederationRussian Medical Academy of Continuig Professional Education of the Ministry of Healthcare of the Russian FederationThe article reflects the changes in both cellular and humoral immunity in rotavirus infection, as well as the correlation between the degree of severity of immunological disorders and the peculiarities of the clinical course of the disease in childhood. The most significant changes in cytokine status are associated with an increase in interleukin-1b, which is a marker of intoxication. In addition, during rotavirus infection in children reduced the level of induced interferon a and у, that justified the application of a2b-interferon that is part of the drug VIFERON®, containing also vitamins E and C. The appointment of drug VIFERON®, along with basic therapy, including the probiotic strains LGG and ВВ12 in the complex of therapeutic measures in children with rotavirus infection allows to improve the dynamics of clinical and immunological indicators, as well as to reduce 1.5 times the number of cases of ARI within 6 months of the follow-up observations after the acute period of the disease.https://detinf.elpub.ru/jour/article/view/375rotavirus infectionimmunitycytokines2b-interferonprobioticschildren |
| spellingShingle | S. G. Gorbunov L. N. Mazankova I. D. Maykova O. I. Demina E. P. Koval FEATURES OF THE IMMUNE RESPONSE AND EFFICACY IMMUNOTHERAPY FOR ROTAVIRUS INFECTION IN CHILDREN Детские инфекции (Москва) rotavirus infection immunity cytokines 2b-interferon probiotics children |
| title | FEATURES OF THE IMMUNE RESPONSE AND EFFICACY IMMUNOTHERAPY FOR ROTAVIRUS INFECTION IN CHILDREN |
| title_full | FEATURES OF THE IMMUNE RESPONSE AND EFFICACY IMMUNOTHERAPY FOR ROTAVIRUS INFECTION IN CHILDREN |
| title_fullStr | FEATURES OF THE IMMUNE RESPONSE AND EFFICACY IMMUNOTHERAPY FOR ROTAVIRUS INFECTION IN CHILDREN |
| title_full_unstemmed | FEATURES OF THE IMMUNE RESPONSE AND EFFICACY IMMUNOTHERAPY FOR ROTAVIRUS INFECTION IN CHILDREN |
| title_short | FEATURES OF THE IMMUNE RESPONSE AND EFFICACY IMMUNOTHERAPY FOR ROTAVIRUS INFECTION IN CHILDREN |
| title_sort | features of the immune response and efficacy immunotherapy for rotavirus infection in children |
| topic | rotavirus infection immunity cytokines 2b-interferon probiotics children |
| url | https://detinf.elpub.ru/jour/article/view/375 |
| work_keys_str_mv | AT sggorbunov featuresoftheimmuneresponseandefficacyimmunotherapyforrotavirusinfectioninchildren AT lnmazankova featuresoftheimmuneresponseandefficacyimmunotherapyforrotavirusinfectioninchildren AT idmaykova featuresoftheimmuneresponseandefficacyimmunotherapyforrotavirusinfectioninchildren AT oidemina featuresoftheimmuneresponseandefficacyimmunotherapyforrotavirusinfectioninchildren AT epkoval featuresoftheimmuneresponseandefficacyimmunotherapyforrotavirusinfectioninchildren |