Multiplicity of benign breast disease lesions and breast cancer risk in African American women
The risk of developing subsequent breast cancer is higher in women diagnosed with benign breast disease (BBD) but these studies were primarily performed in non-Hispanic white populations. Still, these estimates have been used to inform breast cancer risk models that are being used clinically across...
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Frontiers Media S.A.
2024-05-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1410819/full |
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| author | Vidya Patil Julie J. Ruterbusch Wei Chen Julie L. Boerner Eman Abdulfatah Baraa Alosh Visakha Pardeshi Asra N. Shaik Sudeshna Bandyopadhyay Rouba Ali-Fehmi Michele L. Cote |
| author_facet | Vidya Patil Julie J. Ruterbusch Wei Chen Julie L. Boerner Eman Abdulfatah Baraa Alosh Visakha Pardeshi Asra N. Shaik Sudeshna Bandyopadhyay Rouba Ali-Fehmi Michele L. Cote |
| author_sort | Vidya Patil |
| collection | DOAJ |
| description | The risk of developing subsequent breast cancer is higher in women diagnosed with benign breast disease (BBD) but these studies were primarily performed in non-Hispanic white populations. Still, these estimates have been used to inform breast cancer risk models that are being used clinically across all racial and ethnic groups. Given the high breast cancer mortality rates among African American (AA) women, it is critical to study BBD in this population, to ensure the risk models that include this information perform adequately. This study utilized data from AA women who underwent benign breast biopsies at a hospital served by the University Pathology Group in Detroit, Michigan, from 1998 to 2010. Patients were followed for subsequent breast cancers through the population-based Metropolitan Detroit Cancer Surveillance System (MDCSS). BBD lesion scores were assigned to represent the severity or extent of benign breast lesions, with higher scores indicating a greater number of distinct lesion types. Of 3,461 eligible AA women with BBD in the cohort, 6.88% (n=238) subsequently developed breast cancer. Examined individually, six of the eleven lesions (apocrine metaplasia, ductal hyperplasia, lobular hyperplasia, intraductal papilloma, sclerosing adenosis, columnar alterations and radial scars) were significantly associated with increased risk of breast cancer after adjustment for age and year of biopsy and were further considered in multiple lesion models. For every different type of benign breast lesion, subsequent risk of breast cancer increased by 25% (RR=1.25, 95% CI: 1.10, 1.42) after adjustment for age at biopsy and proliferative versus non-proliferative disease. In summary, this study affirms the increased breast cancer risk in AA women with BBD, particularly in those with multiple lesions. These findings have implications for the management of breast cancer risk in millions of women affected by BBD, a high risk group that could benefit from personalized surveillance and risk reduction strategies. |
| format | Article |
| id | doaj-art-77dd82f1cac84200a4535a57320db267 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-77dd82f1cac84200a4535a57320db2672025-08-20T01:47:43ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-05-011410.3389/fonc.2024.14108191410819Multiplicity of benign breast disease lesions and breast cancer risk in African American womenVidya Patil0Julie J. Ruterbusch1Wei Chen2Julie L. Boerner3Eman Abdulfatah4Baraa Alosh5Visakha Pardeshi6Asra N. Shaik7Sudeshna Bandyopadhyay8Rouba Ali-Fehmi9Michele L. Cote10Simon Comprehensive Cancer Center, Indiana University, Indianapolis, IN, United StatesDepartment of Pathology, Wayne State University School of Medicine, Detroit, MI, United StatesDepartment of Pathology, Wayne State University School of Medicine, Detroit, MI, United StatesDepartment of Pathology, Wayne State University School of Medicine, Detroit, MI, United StatesDepartment of Pathology, Wayne State University School of Medicine, Detroit, MI, United StatesDepartment of Pathology, Wayne State University School of Medicine, Detroit, MI, United StatesDepartment of Pathology, Wayne State University School of Medicine, Detroit, MI, United StatesDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, United StatesDepartment of Pathology, Wayne State University School of Medicine, Detroit, MI, United StatesDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, United StatesDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, United StatesThe risk of developing subsequent breast cancer is higher in women diagnosed with benign breast disease (BBD) but these studies were primarily performed in non-Hispanic white populations. Still, these estimates have been used to inform breast cancer risk models that are being used clinically across all racial and ethnic groups. Given the high breast cancer mortality rates among African American (AA) women, it is critical to study BBD in this population, to ensure the risk models that include this information perform adequately. This study utilized data from AA women who underwent benign breast biopsies at a hospital served by the University Pathology Group in Detroit, Michigan, from 1998 to 2010. Patients were followed for subsequent breast cancers through the population-based Metropolitan Detroit Cancer Surveillance System (MDCSS). BBD lesion scores were assigned to represent the severity or extent of benign breast lesions, with higher scores indicating a greater number of distinct lesion types. Of 3,461 eligible AA women with BBD in the cohort, 6.88% (n=238) subsequently developed breast cancer. Examined individually, six of the eleven lesions (apocrine metaplasia, ductal hyperplasia, lobular hyperplasia, intraductal papilloma, sclerosing adenosis, columnar alterations and radial scars) were significantly associated with increased risk of breast cancer after adjustment for age and year of biopsy and were further considered in multiple lesion models. For every different type of benign breast lesion, subsequent risk of breast cancer increased by 25% (RR=1.25, 95% CI: 1.10, 1.42) after adjustment for age at biopsy and proliferative versus non-proliferative disease. In summary, this study affirms the increased breast cancer risk in AA women with BBD, particularly in those with multiple lesions. These findings have implications for the management of breast cancer risk in millions of women affected by BBD, a high risk group that could benefit from personalized surveillance and risk reduction strategies.https://www.frontiersin.org/articles/10.3389/fonc.2024.1410819/fullAfrican Americanbreast cancerbenign breast diseasebreast biopsyhyperplasia |
| spellingShingle | Vidya Patil Julie J. Ruterbusch Wei Chen Julie L. Boerner Eman Abdulfatah Baraa Alosh Visakha Pardeshi Asra N. Shaik Sudeshna Bandyopadhyay Rouba Ali-Fehmi Michele L. Cote Multiplicity of benign breast disease lesions and breast cancer risk in African American women Frontiers in Oncology African American breast cancer benign breast disease breast biopsy hyperplasia |
| title | Multiplicity of benign breast disease lesions and breast cancer risk in African American women |
| title_full | Multiplicity of benign breast disease lesions and breast cancer risk in African American women |
| title_fullStr | Multiplicity of benign breast disease lesions and breast cancer risk in African American women |
| title_full_unstemmed | Multiplicity of benign breast disease lesions and breast cancer risk in African American women |
| title_short | Multiplicity of benign breast disease lesions and breast cancer risk in African American women |
| title_sort | multiplicity of benign breast disease lesions and breast cancer risk in african american women |
| topic | African American breast cancer benign breast disease breast biopsy hyperplasia |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1410819/full |
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