An Increased Plasma D-Dimer Levels During Different Stages of Normal and Complicated Pregnancies Among Women in Bisha, Saudi Arabia
Tareg M Belali Faculty of Applied Medical Sciences, University of Bisha, Bisha, Saudi ArabiaCorrespondence: Tareg M Belali, University of Bisha, Bisha, Saudi Arabia, Tel +966 17623 8162, Email blaly@ub.edu.saIntroduction: Hypercoagulability is one of the most reported state among Pregnant women. Dur...
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Dove Medical Press
2025-08-01
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| description | Tareg M Belali Faculty of Applied Medical Sciences, University of Bisha, Bisha, Saudi ArabiaCorrespondence: Tareg M Belali, University of Bisha, Bisha, Saudi Arabia, Tel +966 17623 8162, Email blaly@ub.edu.saIntroduction: Hypercoagulability is one of the most reported state among Pregnant women. During pregnancy, the concentrations of D-dimer increase in a trimester-dependent- manner. The presence of gestational diabetes (GD) and gestational hypertension (GH) lead to further elevation in D-dimer levels. Pregnant women are at an increased risk of developing Venous thromboembolism (VTE), which can be fatal for both the mother and fetus. Elevated D-dimer levels during pregnancy could result in misdiagnosing other thrombotic diseases, emphasizing the need for further confirmatory testing for VTE. It is crucial to observe the plasma D-dimer concentrations among pregnant women at maternity and children’s hospitals as it plays a role in guiding the anticoagulant treatments and minimizing the incidence of VTE among pregnant women.Aim: The main objective of the current study was to detect the changes in the plasma D-dimer concentrations in healthy and complicated pregnancies across different gestational trimesters among women at the Maternity and Children’s Hospital, Bisha, Saudi Arabia.Methods: A cross-sectional study was conducted from March 2022 to March 2023, involving the analysis of plasma samples collected from 230 pregnant and non-pregnant women. Three samples were collected from each subject in each trimester. D-dimer measurement was conducted using an ACL Elite Pro Automated analyzer.Results: The findings of this study show that D-dimer levels increased progressively throughout the pregnancy trimesters across all study groups. The increase was more noticeable among women with gestational diabetes (278.39 ± 29.808 ng/mL) and gestational hypertension (320.63 ± 12.157 ng/mL), suggesting that these complications influence D-dimer levels more significantly than healthy and multiple pregnancies. Notably, a positive correlation was found between age and D-dimer levels across all groups (p < 0.05), with the highest mean levels in the 41– 48 age group.Conclusion: D-dimer levels rise progressively throughout pregnancy and are significantly elevated in women with gestational diabetes and hypertension. These findings underscore the importance of interpreting D-dimer values in the context of gestational age and pregnancy complications. Additionally, maternal age influences D-dimer concentrations, emphasizing the need to interpret results within the context of age-related physiological changes during pregnancy.Keywords: D-dimer, gestational diabetes, gestational hypertension |
| format | Article |
| id | doaj-art-77d8cbee0e49416fb3894407b401e565 |
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| language | English |
| publishDate | 2025-08-01 |
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| spelling | doaj-art-77d8cbee0e49416fb3894407b401e5652025-08-20T02:58:22ZengDove Medical PressJournal of Blood Medicine1179-27362025-08-01Volume 16Issue 1349358105493An Increased Plasma D-Dimer Levels During Different Stages of Normal and Complicated Pregnancies Among Women in Bisha, Saudi ArabiaBelali TM0Faculty of Applied Medical SciencesTareg M Belali Faculty of Applied Medical Sciences, University of Bisha, Bisha, Saudi ArabiaCorrespondence: Tareg M Belali, University of Bisha, Bisha, Saudi Arabia, Tel +966 17623 8162, Email blaly@ub.edu.saIntroduction: Hypercoagulability is one of the most reported state among Pregnant women. During pregnancy, the concentrations of D-dimer increase in a trimester-dependent- manner. The presence of gestational diabetes (GD) and gestational hypertension (GH) lead to further elevation in D-dimer levels. Pregnant women are at an increased risk of developing Venous thromboembolism (VTE), which can be fatal for both the mother and fetus. Elevated D-dimer levels during pregnancy could result in misdiagnosing other thrombotic diseases, emphasizing the need for further confirmatory testing for VTE. It is crucial to observe the plasma D-dimer concentrations among pregnant women at maternity and children’s hospitals as it plays a role in guiding the anticoagulant treatments and minimizing the incidence of VTE among pregnant women.Aim: The main objective of the current study was to detect the changes in the plasma D-dimer concentrations in healthy and complicated pregnancies across different gestational trimesters among women at the Maternity and Children’s Hospital, Bisha, Saudi Arabia.Methods: A cross-sectional study was conducted from March 2022 to March 2023, involving the analysis of plasma samples collected from 230 pregnant and non-pregnant women. Three samples were collected from each subject in each trimester. D-dimer measurement was conducted using an ACL Elite Pro Automated analyzer.Results: The findings of this study show that D-dimer levels increased progressively throughout the pregnancy trimesters across all study groups. The increase was more noticeable among women with gestational diabetes (278.39 ± 29.808 ng/mL) and gestational hypertension (320.63 ± 12.157 ng/mL), suggesting that these complications influence D-dimer levels more significantly than healthy and multiple pregnancies. Notably, a positive correlation was found between age and D-dimer levels across all groups (p < 0.05), with the highest mean levels in the 41– 48 age group.Conclusion: D-dimer levels rise progressively throughout pregnancy and are significantly elevated in women with gestational diabetes and hypertension. These findings underscore the importance of interpreting D-dimer values in the context of gestational age and pregnancy complications. Additionally, maternal age influences D-dimer concentrations, emphasizing the need to interpret results within the context of age-related physiological changes during pregnancy.Keywords: D-dimer, gestational diabetes, gestational hypertensionhttps://www.dovepress.com/an-increased-plasma-d-dimer-levels-during-different-stages-of-normal-a-peer-reviewed-fulltext-article-JBMD-dimergestational diabetesgestational hypertension |
| spellingShingle | Belali TM An Increased Plasma D-Dimer Levels During Different Stages of Normal and Complicated Pregnancies Among Women in Bisha, Saudi Arabia Journal of Blood Medicine D-dimer gestational diabetes gestational hypertension |
| title | An Increased Plasma D-Dimer Levels During Different Stages of Normal and Complicated Pregnancies Among Women in Bisha, Saudi Arabia |
| title_full | An Increased Plasma D-Dimer Levels During Different Stages of Normal and Complicated Pregnancies Among Women in Bisha, Saudi Arabia |
| title_fullStr | An Increased Plasma D-Dimer Levels During Different Stages of Normal and Complicated Pregnancies Among Women in Bisha, Saudi Arabia |
| title_full_unstemmed | An Increased Plasma D-Dimer Levels During Different Stages of Normal and Complicated Pregnancies Among Women in Bisha, Saudi Arabia |
| title_short | An Increased Plasma D-Dimer Levels During Different Stages of Normal and Complicated Pregnancies Among Women in Bisha, Saudi Arabia |
| title_sort | increased plasma d dimer levels during different stages of normal and complicated pregnancies among women in bisha saudi arabia |
| topic | D-dimer gestational diabetes gestational hypertension |
| url | https://www.dovepress.com/an-increased-plasma-d-dimer-levels-during-different-stages-of-normal-a-peer-reviewed-fulltext-article-JBM |
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