Bullous Lupus: An Atypical Case of Refractory Disease in a Patient with Sulfa Allergy
Bullous systemic lupus erythematosus (BSLE) is a rare cutaneous autoimmune disorder characterized by rapid, widespread vesiculobullous lesions in patients with Systemic Lupus Erythematosus (SLE). BSLE can present as the initial manifestation of SLE and may be a marker of severe disease. In this case...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2020/8873337 |
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| author | Maria Salgado Guerrero Oscar Mena Miranda Ana B. Arevalo Nevena Barjaktarovic Barbara Mendez |
| author_facet | Maria Salgado Guerrero Oscar Mena Miranda Ana B. Arevalo Nevena Barjaktarovic Barbara Mendez |
| author_sort | Maria Salgado Guerrero |
| collection | DOAJ |
| description | Bullous systemic lupus erythematosus (BSLE) is a rare cutaneous autoimmune disorder characterized by rapid, widespread vesiculobullous lesions in patients with Systemic Lupus Erythematosus (SLE). BSLE can present as the initial manifestation of SLE and may be a marker of severe disease. In this case report, we present a case of a 22-year-old African American woman with BSLE and impaired renal function with subsequent nephrotic range proteinuria concerning for lupus nephritis and autoimmune hemolytic anemia, refractory to systemic corticosteroids, immunoglobulin, and mycophenolate mofetil, requiring dapsone after careful desensitization due to prior history of angioedema with sulfa drugs. This case highlights the importance of the prompt recognition of BSLE as the initial manifestations of SLE and illustrates the association of BSLE with severe disease and the benefit of concomitant use of dapsone with corticosteroids and other immunosuppressant drugs, even in patients with a history of sulfa allergy. |
| format | Article |
| id | doaj-art-77d136989aa64846a740c2d5c91ed7ab |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-77d136989aa64846a740c2d5c91ed7ab2025-02-03T06:46:54ZengWileyCase Reports in Rheumatology2090-68892090-68972020-01-01202010.1155/2020/88733378873337Bullous Lupus: An Atypical Case of Refractory Disease in a Patient with Sulfa AllergyMaria Salgado Guerrero0Oscar Mena Miranda1Ana B. Arevalo2Nevena Barjaktarovic3Barbara Mendez4Department of Medicine, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY, USADepartment of Medicine, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY, USADepartment of Medicine, Mount Sinai Morningside-West, New York, NY, USAThe Wright Center for Community Health, Scranton, PA, USADivision of Rheumatology, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY, USABullous systemic lupus erythematosus (BSLE) is a rare cutaneous autoimmune disorder characterized by rapid, widespread vesiculobullous lesions in patients with Systemic Lupus Erythematosus (SLE). BSLE can present as the initial manifestation of SLE and may be a marker of severe disease. In this case report, we present a case of a 22-year-old African American woman with BSLE and impaired renal function with subsequent nephrotic range proteinuria concerning for lupus nephritis and autoimmune hemolytic anemia, refractory to systemic corticosteroids, immunoglobulin, and mycophenolate mofetil, requiring dapsone after careful desensitization due to prior history of angioedema with sulfa drugs. This case highlights the importance of the prompt recognition of BSLE as the initial manifestations of SLE and illustrates the association of BSLE with severe disease and the benefit of concomitant use of dapsone with corticosteroids and other immunosuppressant drugs, even in patients with a history of sulfa allergy.http://dx.doi.org/10.1155/2020/8873337 |
| spellingShingle | Maria Salgado Guerrero Oscar Mena Miranda Ana B. Arevalo Nevena Barjaktarovic Barbara Mendez Bullous Lupus: An Atypical Case of Refractory Disease in a Patient with Sulfa Allergy Case Reports in Rheumatology |
| title | Bullous Lupus: An Atypical Case of Refractory Disease in a Patient with Sulfa Allergy |
| title_full | Bullous Lupus: An Atypical Case of Refractory Disease in a Patient with Sulfa Allergy |
| title_fullStr | Bullous Lupus: An Atypical Case of Refractory Disease in a Patient with Sulfa Allergy |
| title_full_unstemmed | Bullous Lupus: An Atypical Case of Refractory Disease in a Patient with Sulfa Allergy |
| title_short | Bullous Lupus: An Atypical Case of Refractory Disease in a Patient with Sulfa Allergy |
| title_sort | bullous lupus an atypical case of refractory disease in a patient with sulfa allergy |
| url | http://dx.doi.org/10.1155/2020/8873337 |
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