Amyloid Nanofilm-Induced surface mineralization of 3D-Printed Polyetheretherketone scaffolds for in situ orbital bone regeneration and repair
Orbital bone defect repair is both challenging and crucial and requires the comprehensive consideration of anatomical complexity, functional preservation, aesthetic outcomes, postoperative risks, and long-term effects. Polyetheretherketone (PEEK) is a promising orthopedic substitute material due to...
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Elsevier
2024-12-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127524008906 |
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| author | Xiaoming Huang Min Li Shuting Zhang Yanyun Pang Cheng Zhi Zeyuan Chen Hanqing Wang Sidi Zhao Xu Zhang Tong Wu |
| author_facet | Xiaoming Huang Min Li Shuting Zhang Yanyun Pang Cheng Zhi Zeyuan Chen Hanqing Wang Sidi Zhao Xu Zhang Tong Wu |
| author_sort | Xiaoming Huang |
| collection | DOAJ |
| description | Orbital bone defect repair is both challenging and crucial and requires the comprehensive consideration of anatomical complexity, functional preservation, aesthetic outcomes, postoperative risks, and long-term effects. Polyetheretherketone (PEEK) is a promising orthopedic substitute material due to its cortical bone-like elastic modulus, biocompatibility, chemical stability, and natural radiolucency. However, PEEK is bioinert and lacks interfacial bioactivity, which limits its ability to promote bone growth and osseointegration. In this study, we fabricated porous PEEK scaffolds using Fused Deposition Modeling (FDM) 3D printing technology. We employed a phase-transitioned lysozyme (PTL) nanofilm as the organic matrix template to construct a robust hydroxyapatite (HAp) coating both inside and outside the porous PEEK scaffold, generating HAp@PTL@PO-PEEK. The PTL nanofilm acted as a strong glue, enhancing the interfacial bonding strength between the HAp coating and PEEK. In vitro cell biology experiments revealed that HAp@PTL@PO-PEEK promoted the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. Furthermore, the modified scaffolds exhibited excellent osteoconductivity and osteoinductivity in the in vivo repair of rabbit orbital bone defects, promoting new bone formation and guiding new bone growth into the scaffold. Therefore, HAp@PTL@PO-PEEK scaffolds hold potential for clinical craniomaxillofacial bone regeneration and repair. |
| format | Article |
| id | doaj-art-77cf7dc9c2144dc7b680f98c22d62a27 |
| institution | DOAJ |
| issn | 0264-1275 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| series | Materials & Design |
| spelling | doaj-art-77cf7dc9c2144dc7b680f98c22d62a272025-08-20T02:52:35ZengElsevierMaterials & Design0264-12752024-12-0124811351510.1016/j.matdes.2024.113515Amyloid Nanofilm-Induced surface mineralization of 3D-Printed Polyetheretherketone scaffolds for in situ orbital bone regeneration and repairXiaoming Huang0Min Li1Shuting Zhang2Yanyun Pang3Cheng Zhi4Zeyuan Chen5Hanqing Wang6Sidi Zhao7Xu Zhang8Tong Wu9Sichuan Eye Hospital, AIER Eye Hospital Group,No.153,Tianfu Fourth Street, High-tech Zone, Chengdu, 610047, ChinaTianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No. 12 Qixiangtai Road, Heping District, Tianjin 300070, PR China; Tianjin Medical University Institute of Stomatology, No. 12 Qixiangtai Road, Heping District, Tianjin 300070, PR ChinaTianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No. 12 Qixiangtai Road, Heping District, Tianjin 300070, PR China; Tianjin Medical University Institute of Stomatology, No. 12 Qixiangtai Road, Heping District, Tianjin 300070, PR ChinaTianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No. 12 Qixiangtai Road, Heping District, Tianjin 300070, PR China; Tianjin Medical University Institute of Stomatology, No. 12 Qixiangtai Road, Heping District, Tianjin 300070, PR ChinaTianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No. 12 Qixiangtai Road, Heping District, Tianjin 300070, PR China; Tianjin Medical University Institute of Stomatology, No. 12 Qixiangtai Road, Heping District, Tianjin 300070, PR ChinaTianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No. 12 Qixiangtai Road, Heping District, Tianjin 300070, PR China; Tianjin Medical University Institute of Stomatology, No. 12 Qixiangtai Road, Heping District, Tianjin 300070, PR ChinaTianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, No 4. Gansu Road, He-ping District, Tianjin, 300020, ChinaTianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, No 4. Gansu Road, He-ping District, Tianjin, 300020, ChinaTianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No. 12 Qixiangtai Road, Heping District, Tianjin 300070, PR China; Tianjin Medical University Institute of Stomatology, No. 12 Qixiangtai Road, Heping District, Tianjin 300070, PR China; Corresponding authors at: School and Hospital of Stomatology, Institute of Stomatology, Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin Medical University, Tianjin, China, No.12 Qixiangtai Road, Heping District, Tianjin, China.Sichuan Eye Hospital, AIER Eye Hospital Group, No. 153, Tianfu Fourth Street, High-tech Zone, Chengdu, 610047, China.Sichuan Eye Hospital, AIER Eye Hospital Group,No.153,Tianfu Fourth Street, High-tech Zone, Chengdu, 610047, China; Corresponding authors at: School and Hospital of Stomatology, Institute of Stomatology, Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin Medical University, Tianjin, China, No.12 Qixiangtai Road, Heping District, Tianjin, China.Sichuan Eye Hospital, AIER Eye Hospital Group, No. 153, Tianfu Fourth Street, High-tech Zone, Chengdu, 610047, China.Orbital bone defect repair is both challenging and crucial and requires the comprehensive consideration of anatomical complexity, functional preservation, aesthetic outcomes, postoperative risks, and long-term effects. Polyetheretherketone (PEEK) is a promising orthopedic substitute material due to its cortical bone-like elastic modulus, biocompatibility, chemical stability, and natural radiolucency. However, PEEK is bioinert and lacks interfacial bioactivity, which limits its ability to promote bone growth and osseointegration. In this study, we fabricated porous PEEK scaffolds using Fused Deposition Modeling (FDM) 3D printing technology. We employed a phase-transitioned lysozyme (PTL) nanofilm as the organic matrix template to construct a robust hydroxyapatite (HAp) coating both inside and outside the porous PEEK scaffold, generating HAp@PTL@PO-PEEK. The PTL nanofilm acted as a strong glue, enhancing the interfacial bonding strength between the HAp coating and PEEK. In vitro cell biology experiments revealed that HAp@PTL@PO-PEEK promoted the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. Furthermore, the modified scaffolds exhibited excellent osteoconductivity and osteoinductivity in the in vivo repair of rabbit orbital bone defects, promoting new bone formation and guiding new bone growth into the scaffold. Therefore, HAp@PTL@PO-PEEK scaffolds hold potential for clinical craniomaxillofacial bone regeneration and repair.http://www.sciencedirect.com/science/article/pii/S0264127524008906Orbital bone defectsBone reconstructionPolyetheretherketoneAmyloidBiomineralizationHydroxyapatite |
| spellingShingle | Xiaoming Huang Min Li Shuting Zhang Yanyun Pang Cheng Zhi Zeyuan Chen Hanqing Wang Sidi Zhao Xu Zhang Tong Wu Amyloid Nanofilm-Induced surface mineralization of 3D-Printed Polyetheretherketone scaffolds for in situ orbital bone regeneration and repair Materials & Design Orbital bone defects Bone reconstruction Polyetheretherketone Amyloid Biomineralization Hydroxyapatite |
| title | Amyloid Nanofilm-Induced surface mineralization of 3D-Printed Polyetheretherketone scaffolds for in situ orbital bone regeneration and repair |
| title_full | Amyloid Nanofilm-Induced surface mineralization of 3D-Printed Polyetheretherketone scaffolds for in situ orbital bone regeneration and repair |
| title_fullStr | Amyloid Nanofilm-Induced surface mineralization of 3D-Printed Polyetheretherketone scaffolds for in situ orbital bone regeneration and repair |
| title_full_unstemmed | Amyloid Nanofilm-Induced surface mineralization of 3D-Printed Polyetheretherketone scaffolds for in situ orbital bone regeneration and repair |
| title_short | Amyloid Nanofilm-Induced surface mineralization of 3D-Printed Polyetheretherketone scaffolds for in situ orbital bone regeneration and repair |
| title_sort | amyloid nanofilm induced surface mineralization of 3d printed polyetheretherketone scaffolds for in situ orbital bone regeneration and repair |
| topic | Orbital bone defects Bone reconstruction Polyetheretherketone Amyloid Biomineralization Hydroxyapatite |
| url | http://www.sciencedirect.com/science/article/pii/S0264127524008906 |
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