Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic
Purpose. This study aimed to determine whether and how stress-induced thyroid hormone changes occur during the COVID-19 pandemic in the northern area of Tianjin. Methods. This study comprised two groups of study subjects in Tianjin: before (2019) and during (2020) the COVID-19 outbreak. Subjects wer...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/5720875 |
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| _version_ | 1832561290935009280 |
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| author | Dong Weiwei Wu Bei Wang Hong Wu Cailan Shao Hailin Xu Donghong Wang Xiaolai Hao Zhaohu Li Shijun Tan Jian Jia Qiang |
| author_facet | Dong Weiwei Wu Bei Wang Hong Wu Cailan Shao Hailin Xu Donghong Wang Xiaolai Hao Zhaohu Li Shijun Tan Jian Jia Qiang |
| author_sort | Dong Weiwei |
| collection | DOAJ |
| description | Purpose. This study aimed to determine whether and how stress-induced thyroid hormone changes occur during the COVID-19 pandemic in the northern area of Tianjin. Methods. This study comprised two groups of study subjects in Tianjin: before (2019) and during (2020) the COVID-19 outbreak. Subjects were included if they had FT3, FT4, and TSH concentrations and thyroid TPOAb or TgAb information available. People who were pregnant, were lactating, or had mental illness were excluded. We used propensity score matching to form a cohort in which patients had similar baseline characteristics, and their anxiety level was measured by the Hamilton Anxiety Rating Scale (HAMA). Results. Among the 1395 eligible people, 224 in Group A and 224 in Group B had similar propensity scores and were included in the analyses. The detection rate of abnormal thyroid function was decreased in pandemic Group B (69.2% vs. 93.3%, χ2 = 42.725, p<0.01), especially for hypothyroidism (14.29% vs. 35.71%, χ2 = 27.429, p<0.01) and isolated thyroid-related antibodies (25.89% vs. 38.39%, χ2 = 8.023, p<0.01). The level of FT4 (z = −2.821, p<0.01) and HAMA score (7.63 ± 2.07 vs. 5.40 ± 1.65, t = 16.873, p<0.01) went up in Group B; however, TSH (z = −5.238, p<0.01), FT3 (z = −3.089, p=0.002), TgAb (z = −11.814, p<0.01), and TPOAb (z = −9.299, p<0.01) were lower, and HAMA was positive with FT3 (r = 0.208, p<0.01) and FT4 (r = 0.247, p<0.01). Conclusion. People in the northern area of Tianjin during the COVID-19 outbreak were at an increased risk of higher FT4, lower FT3, and lower TSH. The HAMA scores increased in emergency situations and were positively correlated with the levels of FT3 and FT4. |
| format | Article |
| id | doaj-art-77ce08dd3bdb434e8c8ad493b9584d44 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-77ce08dd3bdb434e8c8ad493b9584d442025-02-03T01:25:21ZengWileyInternational Journal of Endocrinology1687-83452022-01-01202210.1155/2022/5720875Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 PandemicDong Weiwei0Wu Bei1Wang Hong2Wu Cailan3Shao Hailin4Xu Donghong5Wang Xiaolai6Hao Zhaohu7Li Shijun8Tan Jian9Jia Qiang10Department of Nuclear MedicineDepartment of Nuclear MedicineRehabilitation Medical DepartmentDepartment of Nuclear MedicineDepartment of Endocrinology MedicineDepartment of Endocrinology MedicineDepartment of Endocrinology MedicineDepartment of Endocrinology MedicineDepartment of HematologyDepartment of Nuclear MedicineDepartment of Nuclear MedicinePurpose. This study aimed to determine whether and how stress-induced thyroid hormone changes occur during the COVID-19 pandemic in the northern area of Tianjin. Methods. This study comprised two groups of study subjects in Tianjin: before (2019) and during (2020) the COVID-19 outbreak. Subjects were included if they had FT3, FT4, and TSH concentrations and thyroid TPOAb or TgAb information available. People who were pregnant, were lactating, or had mental illness were excluded. We used propensity score matching to form a cohort in which patients had similar baseline characteristics, and their anxiety level was measured by the Hamilton Anxiety Rating Scale (HAMA). Results. Among the 1395 eligible people, 224 in Group A and 224 in Group B had similar propensity scores and were included in the analyses. The detection rate of abnormal thyroid function was decreased in pandemic Group B (69.2% vs. 93.3%, χ2 = 42.725, p<0.01), especially for hypothyroidism (14.29% vs. 35.71%, χ2 = 27.429, p<0.01) and isolated thyroid-related antibodies (25.89% vs. 38.39%, χ2 = 8.023, p<0.01). The level of FT4 (z = −2.821, p<0.01) and HAMA score (7.63 ± 2.07 vs. 5.40 ± 1.65, t = 16.873, p<0.01) went up in Group B; however, TSH (z = −5.238, p<0.01), FT3 (z = −3.089, p=0.002), TgAb (z = −11.814, p<0.01), and TPOAb (z = −9.299, p<0.01) were lower, and HAMA was positive with FT3 (r = 0.208, p<0.01) and FT4 (r = 0.247, p<0.01). Conclusion. People in the northern area of Tianjin during the COVID-19 outbreak were at an increased risk of higher FT4, lower FT3, and lower TSH. The HAMA scores increased in emergency situations and were positively correlated with the levels of FT3 and FT4.http://dx.doi.org/10.1155/2022/5720875 |
| spellingShingle | Dong Weiwei Wu Bei Wang Hong Wu Cailan Shao Hailin Xu Donghong Wang Xiaolai Hao Zhaohu Li Shijun Tan Jian Jia Qiang Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic International Journal of Endocrinology |
| title | Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic |
| title_full | Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic |
| title_fullStr | Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic |
| title_full_unstemmed | Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic |
| title_short | Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic |
| title_sort | thyroid hormone changes in the northern area of tianjin during the covid 19 pandemic |
| url | http://dx.doi.org/10.1155/2022/5720875 |
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