An off-target effect of class A CpG-oligonucleotides on suppressing the cyclic GMP-AMP synthase signaling in fibroblastic reticular cells

An off-target effect of class A CpG-oligonucleotides on suppressing the cyclic GMP-AMP synthase signaling in fibroblastic reticular cells

BackgroundClass A CpG-oligonucleotides (ODNs), a Toll-like receptor 9 (TLR9) agonist, have been applied for treating inflammatory diseases and cancer in preclinical studies and clinical trials. A recent study has reported that class A ODNs can activate the Cyclic GMP-AMP synthase (cGAS) signaling to...

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Bibliographic Details
Main Authors: Preethi Jayakumar, Ting Jiang, Hai Huang, Meihong Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
class A ODN
TLR9 agonist
CGAS
ZNF598
fibroblastic reticular cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1576151/full
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