Severe Legionnaires’ Disease Complicated by Rhabdomyolysis and Clinically Resistant to Moxifloxacin in a Splenectomised Patient: Too Much of a Coincidence?
We here report a case of Legionnaires’ disease in a splenectomised patient, complicated by rhabdomyolysis and acute renal failure and characterized by a poor clinical response to moxifloxacin. Splenectomy is not included among the factors, typically associated with higher risk or mortality in patien...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2015/793786 |
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| author | Theocharis Koufakis Ioannis Gabranis Marianneta Chatzopoulou Anastasios Margaritis Maria Tsiakalou |
| author_facet | Theocharis Koufakis Ioannis Gabranis Marianneta Chatzopoulou Anastasios Margaritis Maria Tsiakalou |
| author_sort | Theocharis Koufakis |
| collection | DOAJ |
| description | We here report a case of Legionnaires’ disease in a splenectomised patient, complicated by rhabdomyolysis and acute renal failure and characterized by a poor clinical response to moxifloxacin. Splenectomy is not included among the factors, typically associated with higher risk or mortality in patients with Legionellosis. However, our report is consistent with previous case reports describing severe Legionella infections in asplenic subjects. The possibility that functional or anatomic asplenia may be a factor predisposing to severe clinical course or poor response to therapy in patients with Legionella infection cannot be excluded, deserving further investigation in the future. More studies are required in order to clarify the underlying pathophysiological mechanisms that connect asplenia, immunological response to Legionella, and pathogen’s resistance to antibiotics. |
| format | Article |
| id | doaj-art-77beac9076d24583bf090b4e6a62d097 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-77beac9076d24583bf090b4e6a62d0972025-02-03T01:26:03ZengWileyCase Reports in Infectious Diseases2090-66252090-66332015-01-01201510.1155/2015/793786793786Severe Legionnaires’ Disease Complicated by Rhabdomyolysis and Clinically Resistant to Moxifloxacin in a Splenectomised Patient: Too Much of a Coincidence?Theocharis Koufakis0Ioannis Gabranis1Marianneta Chatzopoulou2Anastasios Margaritis3Maria Tsiakalou4Department of Internal Medicine, General Hospital of Larissa, 1 Tsakalof Street, 41221 Larissa, GreeceDepartment of Internal Medicine, General Hospital of Larissa, 1 Tsakalof Street, 41221 Larissa, GreeceDepartment of Microbiology, General Hospital of Larissa, 41221 Larissa, GreeceDepartment of Internal Medicine, General Hospital of Larissa, 1 Tsakalof Street, 41221 Larissa, GreeceDepartment of Microbiology, General Hospital of Larissa, 41221 Larissa, GreeceWe here report a case of Legionnaires’ disease in a splenectomised patient, complicated by rhabdomyolysis and acute renal failure and characterized by a poor clinical response to moxifloxacin. Splenectomy is not included among the factors, typically associated with higher risk or mortality in patients with Legionellosis. However, our report is consistent with previous case reports describing severe Legionella infections in asplenic subjects. The possibility that functional or anatomic asplenia may be a factor predisposing to severe clinical course or poor response to therapy in patients with Legionella infection cannot be excluded, deserving further investigation in the future. More studies are required in order to clarify the underlying pathophysiological mechanisms that connect asplenia, immunological response to Legionella, and pathogen’s resistance to antibiotics.http://dx.doi.org/10.1155/2015/793786 |
| spellingShingle | Theocharis Koufakis Ioannis Gabranis Marianneta Chatzopoulou Anastasios Margaritis Maria Tsiakalou Severe Legionnaires’ Disease Complicated by Rhabdomyolysis and Clinically Resistant to Moxifloxacin in a Splenectomised Patient: Too Much of a Coincidence? Case Reports in Infectious Diseases |
| title | Severe Legionnaires’ Disease Complicated by Rhabdomyolysis and Clinically Resistant to Moxifloxacin in a Splenectomised Patient: Too Much of a Coincidence? |
| title_full | Severe Legionnaires’ Disease Complicated by Rhabdomyolysis and Clinically Resistant to Moxifloxacin in a Splenectomised Patient: Too Much of a Coincidence? |
| title_fullStr | Severe Legionnaires’ Disease Complicated by Rhabdomyolysis and Clinically Resistant to Moxifloxacin in a Splenectomised Patient: Too Much of a Coincidence? |
| title_full_unstemmed | Severe Legionnaires’ Disease Complicated by Rhabdomyolysis and Clinically Resistant to Moxifloxacin in a Splenectomised Patient: Too Much of a Coincidence? |
| title_short | Severe Legionnaires’ Disease Complicated by Rhabdomyolysis and Clinically Resistant to Moxifloxacin in a Splenectomised Patient: Too Much of a Coincidence? |
| title_sort | severe legionnaires disease complicated by rhabdomyolysis and clinically resistant to moxifloxacin in a splenectomised patient too much of a coincidence |
| url | http://dx.doi.org/10.1155/2015/793786 |
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