New Perspectives in the Fight Against Multidrug-Resistant Bacteria: The Potential of Endolysin Biocomposites
The growing threat of multidrug-resistant bacteria requires innovative therapies beyond traditional antibiotics. This review highlights the potential of endolysin biocomposites using alginate oligosaccharides (AOSs) and modified cellulose (CL) as stabilizers. AOSs could enhance endolysin stability a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/5/457 |
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| author | Carlos E. Camacho-González Cesar S. Cardona-Felix Alejandro Pérez-Larios Víctor M. Zamora-Gasga Sonia G. Sáyago-Ayerdi Jorge A. Sánchez-Burgos |
| author_facet | Carlos E. Camacho-González Cesar S. Cardona-Felix Alejandro Pérez-Larios Víctor M. Zamora-Gasga Sonia G. Sáyago-Ayerdi Jorge A. Sánchez-Burgos |
| author_sort | Carlos E. Camacho-González |
| collection | DOAJ |
| description | The growing threat of multidrug-resistant bacteria requires innovative therapies beyond traditional antibiotics. This review highlights the potential of endolysin biocomposites using alginate oligosaccharides (AOSs) and modified cellulose (CL) as stabilizers. AOSs could enhance endolysin stability and potentially support colonic fermentation, producing short-chain fatty acids that may synergize with endolysins to combat pathogens and improve gut health. KZ144 and LysPA26 are proposed as optimal candidates for their broad pH range, divalent cation tolerance, and potential effectiveness against Gram-positive and Gram-negative pathogens. Integrating AOSs and CL into biocomposites could offer a novel dual-action strategy against gastrointestinal diseases while potentially reducing antibiotic dependence. |
| format | Article |
| id | doaj-art-77bcce4df2e8481eb63e37c97b88498f |
| institution | OA Journals |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-77bcce4df2e8481eb63e37c97b88498f2025-08-20T02:33:43ZengMDPI AGAntibiotics2079-63822025-04-0114545710.3390/antibiotics14050457New Perspectives in the Fight Against Multidrug-Resistant Bacteria: The Potential of Endolysin BiocompositesCarlos E. Camacho-González0Cesar S. Cardona-Felix1Alejandro Pérez-Larios2Víctor M. Zamora-Gasga3Sonia G. Sáyago-Ayerdi4Jorge A. Sánchez-Burgos5Food Research Laboratory, Technological Institute of Tepic, National Technological Institute of Mexico, Instituto Tecnológico Avenue No. 2595, Lagos del Country, Tepic C.P. 63175, Nayarit, MexicoInstituto Politécnico Nacional, CICIMAR, Av. Instituto Politécnico Nacional S/N, Col. Playa Palo de Santa Rita, La Paz C.P. 23096, Baja California, MexicoCentro Universitario de Los Altos, Universidad de Guadalajara, Av. Rafael Casillas Aceves No. 1200, Tepatitlán de Morelos C.P. 47620, Jalisco, MexicoFood Research Laboratory, Technological Institute of Tepic, National Technological Institute of Mexico, Instituto Tecnológico Avenue No. 2595, Lagos del Country, Tepic C.P. 63175, Nayarit, MexicoFood Research Laboratory, Technological Institute of Tepic, National Technological Institute of Mexico, Instituto Tecnológico Avenue No. 2595, Lagos del Country, Tepic C.P. 63175, Nayarit, MexicoFood Research Laboratory, Technological Institute of Tepic, National Technological Institute of Mexico, Instituto Tecnológico Avenue No. 2595, Lagos del Country, Tepic C.P. 63175, Nayarit, MexicoThe growing threat of multidrug-resistant bacteria requires innovative therapies beyond traditional antibiotics. This review highlights the potential of endolysin biocomposites using alginate oligosaccharides (AOSs) and modified cellulose (CL) as stabilizers. AOSs could enhance endolysin stability and potentially support colonic fermentation, producing short-chain fatty acids that may synergize with endolysins to combat pathogens and improve gut health. KZ144 and LysPA26 are proposed as optimal candidates for their broad pH range, divalent cation tolerance, and potential effectiveness against Gram-positive and Gram-negative pathogens. Integrating AOSs and CL into biocomposites could offer a novel dual-action strategy against gastrointestinal diseases while potentially reducing antibiotic dependence.https://www.mdpi.com/2079-6382/14/5/457endolysinscolonic fermentationalginate oligosaccharidesmodified cellulose |
| spellingShingle | Carlos E. Camacho-González Cesar S. Cardona-Felix Alejandro Pérez-Larios Víctor M. Zamora-Gasga Sonia G. Sáyago-Ayerdi Jorge A. Sánchez-Burgos New Perspectives in the Fight Against Multidrug-Resistant Bacteria: The Potential of Endolysin Biocomposites Antibiotics endolysins colonic fermentation alginate oligosaccharides modified cellulose |
| title | New Perspectives in the Fight Against Multidrug-Resistant Bacteria: The Potential of Endolysin Biocomposites |
| title_full | New Perspectives in the Fight Against Multidrug-Resistant Bacteria: The Potential of Endolysin Biocomposites |
| title_fullStr | New Perspectives in the Fight Against Multidrug-Resistant Bacteria: The Potential of Endolysin Biocomposites |
| title_full_unstemmed | New Perspectives in the Fight Against Multidrug-Resistant Bacteria: The Potential of Endolysin Biocomposites |
| title_short | New Perspectives in the Fight Against Multidrug-Resistant Bacteria: The Potential of Endolysin Biocomposites |
| title_sort | new perspectives in the fight against multidrug resistant bacteria the potential of endolysin biocomposites |
| topic | endolysins colonic fermentation alginate oligosaccharides modified cellulose |
| url | https://www.mdpi.com/2079-6382/14/5/457 |
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