The impact of periodic leg movements during sleep on neurological recovery in patients with acute mild cerebral infarction
ObjectiveAcute minor cerebral infarction is a common cerebrovascular disease, and its prognosis is influenced by various factors. This study aims to explore the relationship between nocturnal periodic leg movements and neurological function 3 months after acute mild cerebral infarction.MethodsA retr...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1610871/full |
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| author | Shutong Sun Yixi Zheng Liwen Xu Wenyi Yu Tianyu Jing Tianyu Jing Gang Xu Tieyu Tang Cheng Chu |
| author_facet | Shutong Sun Yixi Zheng Liwen Xu Wenyi Yu Tianyu Jing Tianyu Jing Gang Xu Tieyu Tang Cheng Chu |
| author_sort | Shutong Sun |
| collection | DOAJ |
| description | ObjectiveAcute minor cerebral infarction is a common cerebrovascular disease, and its prognosis is influenced by various factors. This study aims to explore the relationship between nocturnal periodic leg movements and neurological function 3 months after acute mild cerebral infarction.MethodsA retrospective study was conducted based on hospital records, involving patients diagnosed with acute minor cerebral infarction who underwent polysomnography at Yangzhou University Affiliated Hospital from September 2023 to October 2024. Patients were followed up by phone 3 months later, and the modified Rankin Scale (mRS) was completed. Based on the scores, patients were divided into a good prognosis group (0–2 points) and a poor prognosis group (3–6 points). The correlation between sleep-related scales, polysomnography, and prognosis was analyzed using Spearman correlation analysis. Further, indicators related to prognosis (data with p < 0.05 in correlation analysis) along with age, hypertension, cholesterol, and radiate crown area cerebral infarction were included in a binary logistic regression analysis to assess factors affecting neurological function in patients with acute minor cerebral infarction after 3 months.ResultsA total of 766 patients were included, with 203 patients in the poor prognosis group. The results indicated that patients with a history of hypertension (OR = 0.589, 95% CI = 0.401 to 0.863), higher HCY levels (OR = 1.037, 95% CI = 1.005 to 1.070), radiate crown area cerebral infarction (OR = 1.655, 95% CI = 1.150 to 2.382), longer N1% (OR = 1.032, 95% CI = 1.013 to 1.052), and higher PLMI (OR = 1.006, 95% CI = 1.001 to 1.010) are risk factors for the prognosis of Acute minor cerebral infarction patients at 3 months (p < 0.05).ConclusionPLMS is an independent risk factor for impaired neurological recovery in patients with acute minor cerebral infarction. This finding suggests that systematic sleep monitoring should be conducted in clinical practice for acute minor cerebral infarction, and early identification and intervention targeting PLMS may become a new focus for improving long-term prognosis in patients. |
| format | Article |
| id | doaj-art-77bc8ad5b3fd4c789bf6d7337fd5f8eb |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-77bc8ad5b3fd4c789bf6d7337fd5f8eb2025-08-20T03:34:08ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-08-011610.3389/fneur.2025.16108711610871The impact of periodic leg movements during sleep on neurological recovery in patients with acute mild cerebral infarctionShutong Sun0Yixi Zheng1Liwen Xu2Wenyi Yu3Tianyu Jing4Tianyu Jing5Gang Xu6Tieyu Tang7Cheng Chu8Department of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaDepartment of Intensive Care Unit, The Jiangyin No.3 People’s Hospital, Wuxi, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaDepartment of Neurology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, ChinaObjectiveAcute minor cerebral infarction is a common cerebrovascular disease, and its prognosis is influenced by various factors. This study aims to explore the relationship between nocturnal periodic leg movements and neurological function 3 months after acute mild cerebral infarction.MethodsA retrospective study was conducted based on hospital records, involving patients diagnosed with acute minor cerebral infarction who underwent polysomnography at Yangzhou University Affiliated Hospital from September 2023 to October 2024. Patients were followed up by phone 3 months later, and the modified Rankin Scale (mRS) was completed. Based on the scores, patients were divided into a good prognosis group (0–2 points) and a poor prognosis group (3–6 points). The correlation between sleep-related scales, polysomnography, and prognosis was analyzed using Spearman correlation analysis. Further, indicators related to prognosis (data with p < 0.05 in correlation analysis) along with age, hypertension, cholesterol, and radiate crown area cerebral infarction were included in a binary logistic regression analysis to assess factors affecting neurological function in patients with acute minor cerebral infarction after 3 months.ResultsA total of 766 patients were included, with 203 patients in the poor prognosis group. The results indicated that patients with a history of hypertension (OR = 0.589, 95% CI = 0.401 to 0.863), higher HCY levels (OR = 1.037, 95% CI = 1.005 to 1.070), radiate crown area cerebral infarction (OR = 1.655, 95% CI = 1.150 to 2.382), longer N1% (OR = 1.032, 95% CI = 1.013 to 1.052), and higher PLMI (OR = 1.006, 95% CI = 1.001 to 1.010) are risk factors for the prognosis of Acute minor cerebral infarction patients at 3 months (p < 0.05).ConclusionPLMS is an independent risk factor for impaired neurological recovery in patients with acute minor cerebral infarction. This finding suggests that systematic sleep monitoring should be conducted in clinical practice for acute minor cerebral infarction, and early identification and intervention targeting PLMS may become a new focus for improving long-term prognosis in patients.https://www.frontiersin.org/articles/10.3389/fneur.2025.1610871/fullsleep periodic limb movementacute mild cerebral infarctionneurological functionprognosissleep disorders |
| spellingShingle | Shutong Sun Yixi Zheng Liwen Xu Wenyi Yu Tianyu Jing Tianyu Jing Gang Xu Tieyu Tang Cheng Chu The impact of periodic leg movements during sleep on neurological recovery in patients with acute mild cerebral infarction Frontiers in Neurology sleep periodic limb movement acute mild cerebral infarction neurological function prognosis sleep disorders |
| title | The impact of periodic leg movements during sleep on neurological recovery in patients with acute mild cerebral infarction |
| title_full | The impact of periodic leg movements during sleep on neurological recovery in patients with acute mild cerebral infarction |
| title_fullStr | The impact of periodic leg movements during sleep on neurological recovery in patients with acute mild cerebral infarction |
| title_full_unstemmed | The impact of periodic leg movements during sleep on neurological recovery in patients with acute mild cerebral infarction |
| title_short | The impact of periodic leg movements during sleep on neurological recovery in patients with acute mild cerebral infarction |
| title_sort | impact of periodic leg movements during sleep on neurological recovery in patients with acute mild cerebral infarction |
| topic | sleep periodic limb movement acute mild cerebral infarction neurological function prognosis sleep disorders |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1610871/full |
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