A bibliometric analysis of inflammation and thyroid carcinoma: research trends and future perspectives
Background and objectivesThyroid carcinoma, one of the most prevalent endocrine malignancies, has witnessed a gradual increase in incidence in recent years. Accumulating evidence has demonstrated that inflammation plays a pivotal role in the pathogenesis, progression, and prognosis of thyroid carcin...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1593006/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849706975627051008 |
|---|---|
| author | Yanhui Feng Caiqi Huang Xiaoman Liu Zhesi Xiao Lu Wang Zhengjia Lu Jia Ming |
| author_facet | Yanhui Feng Caiqi Huang Xiaoman Liu Zhesi Xiao Lu Wang Zhengjia Lu Jia Ming |
| author_sort | Yanhui Feng |
| collection | DOAJ |
| description | Background and objectivesThyroid carcinoma, one of the most prevalent endocrine malignancies, has witnessed a gradual increase in incidence in recent years. Accumulating evidence has demonstrated that inflammation plays a pivotal role in the pathogenesis, progression, and prognosis of thyroid carcinoma, with a significant association between certain malignancies and chronic inflammatory processes. This study conducts a bibliometric analysis of literature on inflammation and thyroid carcinoma over 24 years, aiming to identify trends and research dynamics. The findings are expected to deepen understanding of thyroid carcinoma mechanisms and guide new therapeutic strategies.MethodsWe used the advanced search function of the Web of Science Core Collection to systematically screen and curate articles on inflammation and thyroid carcinoma published between 2000 and 2024. Using Microsoft Excel 2019, we analyzed and visualized publication volume and growth trends. For co-occurrence and clustering analysis of countries, institutions, authors, journals, references, and keywords, we employed VOSviewer, CiteSpace, and the ‘bibliometrix’ package in R. Keyword visualization identified 10 major clusters, including sodium iodide symporter, total thyroidectomy, peroxisome proliferator-activated receptor, papillary thyroid microcarcinoma, therapeutic radiopharmaceuticals, zoological gardens, endoscopic thyroidectomy, mixed cryoglobulinemia, fine needle aspiration, and clinical evaluation. The most frequent keywords were cancer, thyroid cancer, and inflammation.ResultsWe included a total of 1,441 articles published between 2000 and 2024, contributed by 8,326 authors from 2,054 institutions across 70 countries. These articles were published in 625 journals, encompassing 59,808 references and 6,340 keywords. The publication output demonstrated a consistent upward trend over the study period. Among the contributing nations, China emerged as the most prolific country in terms of publication volume. The leading institution was the University of Pisa in Italy. The most productive author was Antonelli, Alessandro, and the leading journal was Thyroid.ConclusionThis bibliometric analysis shows that research on inflammation and thyroid carcinoma is a rapidly evolving field, marked by diverse themes and in-depth studies. Advances in technology and extensive research are expected to clarify how inflammation drives thyroid carcinoma initiation and progression. This deeper understanding will lead to new approaches in diagnosis, prevention, and treatment of thyroid carcinoma. |
| format | Article |
| id | doaj-art-77bb7c7f53c14acbae60dfc1180a30ce |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-77bb7c7f53c14acbae60dfc1180a30ce2025-08-20T03:16:03ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.15930061593006A bibliometric analysis of inflammation and thyroid carcinoma: research trends and future perspectivesYanhui FengCaiqi HuangXiaoman LiuZhesi XiaoLu WangZhengjia LuJia MingBackground and objectivesThyroid carcinoma, one of the most prevalent endocrine malignancies, has witnessed a gradual increase in incidence in recent years. Accumulating evidence has demonstrated that inflammation plays a pivotal role in the pathogenesis, progression, and prognosis of thyroid carcinoma, with a significant association between certain malignancies and chronic inflammatory processes. This study conducts a bibliometric analysis of literature on inflammation and thyroid carcinoma over 24 years, aiming to identify trends and research dynamics. The findings are expected to deepen understanding of thyroid carcinoma mechanisms and guide new therapeutic strategies.MethodsWe used the advanced search function of the Web of Science Core Collection to systematically screen and curate articles on inflammation and thyroid carcinoma published between 2000 and 2024. Using Microsoft Excel 2019, we analyzed and visualized publication volume and growth trends. For co-occurrence and clustering analysis of countries, institutions, authors, journals, references, and keywords, we employed VOSviewer, CiteSpace, and the ‘bibliometrix’ package in R. Keyword visualization identified 10 major clusters, including sodium iodide symporter, total thyroidectomy, peroxisome proliferator-activated receptor, papillary thyroid microcarcinoma, therapeutic radiopharmaceuticals, zoological gardens, endoscopic thyroidectomy, mixed cryoglobulinemia, fine needle aspiration, and clinical evaluation. The most frequent keywords were cancer, thyroid cancer, and inflammation.ResultsWe included a total of 1,441 articles published between 2000 and 2024, contributed by 8,326 authors from 2,054 institutions across 70 countries. These articles were published in 625 journals, encompassing 59,808 references and 6,340 keywords. The publication output demonstrated a consistent upward trend over the study period. Among the contributing nations, China emerged as the most prolific country in terms of publication volume. The leading institution was the University of Pisa in Italy. The most productive author was Antonelli, Alessandro, and the leading journal was Thyroid.ConclusionThis bibliometric analysis shows that research on inflammation and thyroid carcinoma is a rapidly evolving field, marked by diverse themes and in-depth studies. Advances in technology and extensive research are expected to clarify how inflammation drives thyroid carcinoma initiation and progression. This deeper understanding will lead to new approaches in diagnosis, prevention, and treatment of thyroid carcinoma.https://www.frontiersin.org/articles/10.3389/fonc.2025.1593006/fullthyroid carcinomainflammationbibliometric analysisWeb of ScienceVOSviewerCiteSpace |
| spellingShingle | Yanhui Feng Caiqi Huang Xiaoman Liu Zhesi Xiao Lu Wang Zhengjia Lu Jia Ming A bibliometric analysis of inflammation and thyroid carcinoma: research trends and future perspectives Frontiers in Oncology thyroid carcinoma inflammation bibliometric analysis Web of Science VOSviewer CiteSpace |
| title | A bibliometric analysis of inflammation and thyroid carcinoma: research trends and future perspectives |
| title_full | A bibliometric analysis of inflammation and thyroid carcinoma: research trends and future perspectives |
| title_fullStr | A bibliometric analysis of inflammation and thyroid carcinoma: research trends and future perspectives |
| title_full_unstemmed | A bibliometric analysis of inflammation and thyroid carcinoma: research trends and future perspectives |
| title_short | A bibliometric analysis of inflammation and thyroid carcinoma: research trends and future perspectives |
| title_sort | bibliometric analysis of inflammation and thyroid carcinoma research trends and future perspectives |
| topic | thyroid carcinoma inflammation bibliometric analysis Web of Science VOSviewer CiteSpace |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1593006/full |
| work_keys_str_mv | AT yanhuifeng abibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives AT caiqihuang abibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives AT xiaomanliu abibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives AT zhesixiao abibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives AT luwang abibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives AT zhengjialu abibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives AT jiaming abibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives AT yanhuifeng bibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives AT caiqihuang bibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives AT xiaomanliu bibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives AT zhesixiao bibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives AT luwang bibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives AT zhengjialu bibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives AT jiaming bibliometricanalysisofinflammationandthyroidcarcinomaresearchtrendsandfutureperspectives |