Cardiovascular Risk in Psoriasis: A Population-Based Analysis with Assessment of the Framingham Risk Score
Objective. To examine the utility of the Framingham risk score (FRS) in estimating cardiovascular risk in psoriasis. Methods. We compared the predicted 10-year risk of cardiovascular events, namely, cardiovascular death, myocardial infarction, heart failure, percutaneous transluminal coronary angiop...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2013/371569 |
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| author | Elena Myasoedova Bharath Manu Akkara Veetil Eric L. Matteson Hilal Maradit Kremers Marian T. McEvoy Cynthia S. Crowson |
| author_facet | Elena Myasoedova Bharath Manu Akkara Veetil Eric L. Matteson Hilal Maradit Kremers Marian T. McEvoy Cynthia S. Crowson |
| author_sort | Elena Myasoedova |
| collection | DOAJ |
| description | Objective. To examine the utility of the Framingham risk score (FRS) in estimating cardiovascular risk in psoriasis. Methods. We compared the predicted 10-year risk of cardiovascular events, namely, cardiovascular death, myocardial infarction, heart failure, percutaneous transluminal coronary angioplasty, and coronary artery bypass grafting using the FRS, to the observed risk of cardiovascular events in a population-based cohort of patients with psoriasis. Patients with incident or prevalent adult-onset psoriasis aged 30–79 years without prior history of cardiovascular disease were included. Results. Among the 1197 patients with predicted risk scores, the median FRS was 6.0%, while the observed 10-year cardiovascular risk was 6.9% (standardized incidence ratio (SIR): 1.14; 95% confidence interval (CI): 0.92–1.42). The SIR was not elevated for women nor for men. The differences between observed and predicted cardiovascular risks in patients <60 years (SIR: 1.01; 95% CI: 0.73–1.41) or ≥60 years (SIR: 1.26; 95% CI: 0.95–1.68) were not statistically significant. Conclusion. There was no apparent difference between observed and predicted cardiovascular risks in patients with psoriasis in our study. FRS reasonably estimated cardiovascular risk in both men and women as well as in younger and older psoriasis patients, suggesting that FRS can be used in risk stratification in psoriasis without further adjustment. |
| format | Article |
| id | doaj-art-77b3e09442954e94a004bcd88c0e8fea |
| institution | OA Journals |
| issn | 2090-908X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-77b3e09442954e94a004bcd88c0e8fea2025-08-20T02:07:06ZengWileyScientifica2090-908X2013-01-01201310.1155/2013/371569371569Cardiovascular Risk in Psoriasis: A Population-Based Analysis with Assessment of the Framingham Risk ScoreElena Myasoedova0Bharath Manu Akkara Veetil1Eric L. Matteson2Hilal Maradit Kremers3Marian T. McEvoy4Cynthia S. Crowson5Division of Rheumatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USADivision of Rheumatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USADivision of Rheumatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USADepartment of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USADepartment of Dermatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USADivision of Rheumatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USAObjective. To examine the utility of the Framingham risk score (FRS) in estimating cardiovascular risk in psoriasis. Methods. We compared the predicted 10-year risk of cardiovascular events, namely, cardiovascular death, myocardial infarction, heart failure, percutaneous transluminal coronary angioplasty, and coronary artery bypass grafting using the FRS, to the observed risk of cardiovascular events in a population-based cohort of patients with psoriasis. Patients with incident or prevalent adult-onset psoriasis aged 30–79 years without prior history of cardiovascular disease were included. Results. Among the 1197 patients with predicted risk scores, the median FRS was 6.0%, while the observed 10-year cardiovascular risk was 6.9% (standardized incidence ratio (SIR): 1.14; 95% confidence interval (CI): 0.92–1.42). The SIR was not elevated for women nor for men. The differences between observed and predicted cardiovascular risks in patients <60 years (SIR: 1.01; 95% CI: 0.73–1.41) or ≥60 years (SIR: 1.26; 95% CI: 0.95–1.68) were not statistically significant. Conclusion. There was no apparent difference between observed and predicted cardiovascular risks in patients with psoriasis in our study. FRS reasonably estimated cardiovascular risk in both men and women as well as in younger and older psoriasis patients, suggesting that FRS can be used in risk stratification in psoriasis without further adjustment.http://dx.doi.org/10.1155/2013/371569 |
| spellingShingle | Elena Myasoedova Bharath Manu Akkara Veetil Eric L. Matteson Hilal Maradit Kremers Marian T. McEvoy Cynthia S. Crowson Cardiovascular Risk in Psoriasis: A Population-Based Analysis with Assessment of the Framingham Risk Score Scientifica |
| title | Cardiovascular Risk in Psoriasis: A Population-Based Analysis with Assessment of the Framingham Risk Score |
| title_full | Cardiovascular Risk in Psoriasis: A Population-Based Analysis with Assessment of the Framingham Risk Score |
| title_fullStr | Cardiovascular Risk in Psoriasis: A Population-Based Analysis with Assessment of the Framingham Risk Score |
| title_full_unstemmed | Cardiovascular Risk in Psoriasis: A Population-Based Analysis with Assessment of the Framingham Risk Score |
| title_short | Cardiovascular Risk in Psoriasis: A Population-Based Analysis with Assessment of the Framingham Risk Score |
| title_sort | cardiovascular risk in psoriasis a population based analysis with assessment of the framingham risk score |
| url | http://dx.doi.org/10.1155/2013/371569 |
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