Oncolytic alphavirus-induced extracellular vesicles counteract the immunosuppressive effect of melanoma-derived extracellular vesicles

Oncolytic alphavirus-induced extracellular vesicles counteract the immunosuppressive effect of melanoma-derived extracellular vesicles

Abstract Extracellular vesicles (EVs)-mediated communication by cancer cells contributes towards the pro-tumoral reprogramming of the tumor microenvironment. Viral infection has been observed to alter the biogenesis and cargo of EVs secreted from host cells in the context of infectious biology. Howe...

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Main Authors: Darshak K. Bhatt, Annemarie Boerma, Silvina Odete Bustos, Andréia Hanada Otake, Alexis Germán Murillo Carrasco, Patrícia Pintor Reis, Roger Chammas, Toos Daemen, Luciana Nogueira de Sousa Andrade
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Extracellular vesicles
Oncolytic virus
Immunomodulatory
Melanoma
Online Access:https://doi.org/10.1038/s41598-024-82331-9
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