scTail: precise polyadenylation site detection and its alternative usage analysis from reads 1 preserved 3′ scRNA-seq data
Abstract The first-strand reads (often reads 1) of three-prime single-cell RNA-seq (3′ scRNA-seq) can contain informative cDNA for analysis of polyadenylation sites (PAS), but are often overlooked or trimmed. Here, we describe a computational method, scTail, to identify PAS using first-strand reads...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-025-03710-7 |
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