Relationship between dietary acid-base load and non-insulin-based resistance measures in patients with chronic kidney disease

Relationship between dietary acid-base load and non-insulin-based resistance measures in patients with chronic kidney disease

This study explored the associations between triglyceride glucose (TyG), TyG with body mass index (TyG-BMI), triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) and the effects of dietary acid-base load in patients with chronic...

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Main Authors: Hui Huang, Qian Wang, Ruimin Zhang, Fang Liu, Yue Niu, Yayong Luo, Junqian Wang, Shuang Li, Zhengchun Tang, Xueying Cao, Xiaolong Wang, Jian Yang, Sha Luo, Weizhu Deng, Weiguang Zhang, Ying Zheng, Yong Wang, Li Zhang, Guangyan Cai, Xiangmei Chen, Zheyi Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Endocrinology
Subjects:
chronic kidney disease
dietary acid-base load
triglyceride glucose-body mass index
metabolic score for insulin resistance
insulin resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1589528/full
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Summary:This study explored the associations between triglyceride glucose (TyG), TyG with body mass index (TyG-BMI), triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) and the effects of dietary acid-base load in patients with chronic kidney disease (CKD).MethodsA total of 288 patients with CKD were included in this study. Four non-insulin-based insulin resistance (IR) markers were used to assess IR levels in patients with CKD; dietary intake – 24-h dietary recall; and diet-based acidity – potential renal acid load (PRAL), net endogenous acid production (NEAP), and dietary acid load (DAL). Multiple linear regression analysis correlated dietary acid-base load and non-insulin-based IR markers.ResultsSpearman’s correlation indicated DAL was significantly associated with TyG-BMI (r = 0.251, P < 0.001) and METS-IR (r = 0.274, P < 0.001), but weakly correlated with the TG/HDL-C ratio (r = 0.14, P = 0.018). After adjusting for sex, age, energy, hypertension (HTN), diabetes, and estimated glomerular filtration rate, multiple linear regression analysis showed that DAL was associated with TyG-BMI (β = 0.336; P = 0.008) and METS-IR (β = 0.091; P = 0.007).ConclusionsPatients with the highest DAL scores had the highest TyG-BMI, TyG, TG/HDL-C ratio, and METS-IR. After adjusting for confounders, there was a significant positive association between DAL and TyG-BMI and METS-IR.
ISSN:1664-2392

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