Analysis of the clinical characteristics of immune checkpoint inhibitor-related hypophysitis
ObjectiveTo analyze the clinical characteristics of immune checkpoint inhibitor (ICI)-related hypophysitis. MethodsA retrospective analysis was conducted on patients diagnosed with ICI-related hypophysitis and treated at the Department of Endocrinology, The First Affiliated Hospital with Nanjing Med...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shanghai Chinese Clinical Medicine Press Co., Ltd.
2025-08-01
|
| Series: | Zhongguo Linchuang Yixue |
| Subjects: | |
| Online Access: | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20250397 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849223001123323904 |
|---|---|
| author | Zhixiao WANG Yun SHI Min SUN Xuqin ZHENG Tao YANG Min SHEN |
| author_facet | Zhixiao WANG Yun SHI Min SUN Xuqin ZHENG Tao YANG Min SHEN |
| author_sort | Zhixiao WANG |
| collection | DOAJ |
| description | ObjectiveTo analyze the clinical characteristics of immune checkpoint inhibitor (ICI)-related hypophysitis. MethodsA retrospective analysis was conducted on patients diagnosed with ICI-related hypophysitis and treated at the Department of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, between January 2020 and March 2025. Clinical manifestations and prognosis of patients were analyzed. ResultsEleven patients with ICI-related hypophysitis were included. The average age was (62.27±7.63) years, and 9 patients (81.82%) were male. The median time to onset was 9.1 months, and the median number of treatment cycles received was 5. The primary initial symptoms were fatigue and anorexia. Hyponatremia was present in 3 patients (27.27%). Evaluation of anterior pituitary function revealed adrenocorticotropic hormone deficiency as the most common manifestation (90.91%, 10/11), followed by hyperprolactinemia (81.82%, 9/11). Posterior pituitary function remained normal in all patients. Pituitary magnetic resonance imaging showed no abnormality in 4 patients (44.44%). Thyroid dysfunction was observed in 6 patients (54.55%), one of whom (9.09%) also exhibited pancreatic endocrine dysfunction. The average follow-up duration was 36.5 months. Eight patients (72.73%) were alive at the last follow-up. None of the patients recovered their pituitary hormone function. ConclusionsEndocrine adverse events induced by ICIs can involve multiple glandular systems. Clinicians should be highly vigilant for the possibility of ICI-induced hypophysitis in patients receiving ICIs who present with symptoms such as fatigue, anorexia, and hyponatremia. |
| format | Article |
| id | doaj-art-77ae8970b47e4865bfda9fbb569f8029 |
| institution | Kabale University |
| issn | 1008-6358 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Shanghai Chinese Clinical Medicine Press Co., Ltd. |
| record_format | Article |
| series | Zhongguo Linchuang Yixue |
| spelling | doaj-art-77ae8970b47e4865bfda9fbb569f80292025-08-26T01:29:39ZengShanghai Chinese Clinical Medicine Press Co., Ltd.Zhongguo Linchuang Yixue1008-63582025-08-0132452953510.12025/j.issn.1008-6358.2025.2025039720250397Analysis of the clinical characteristics of immune checkpoint inhibitor-related hypophysitisZhixiao WANG0Yun SHI1Min SUN2Xuqin ZHENG3Tao YANG4Min SHEN5Department of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, Jiangsu, ChinaDepartment of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, Jiangsu, ChinaDepartment of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, Jiangsu, ChinaDepartment of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, Jiangsu, ChinaDepartment of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, Jiangsu, ChinaDepartment of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, Jiangsu, ChinaObjectiveTo analyze the clinical characteristics of immune checkpoint inhibitor (ICI)-related hypophysitis. MethodsA retrospective analysis was conducted on patients diagnosed with ICI-related hypophysitis and treated at the Department of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, between January 2020 and March 2025. Clinical manifestations and prognosis of patients were analyzed. ResultsEleven patients with ICI-related hypophysitis were included. The average age was (62.27±7.63) years, and 9 patients (81.82%) were male. The median time to onset was 9.1 months, and the median number of treatment cycles received was 5. The primary initial symptoms were fatigue and anorexia. Hyponatremia was present in 3 patients (27.27%). Evaluation of anterior pituitary function revealed adrenocorticotropic hormone deficiency as the most common manifestation (90.91%, 10/11), followed by hyperprolactinemia (81.82%, 9/11). Posterior pituitary function remained normal in all patients. Pituitary magnetic resonance imaging showed no abnormality in 4 patients (44.44%). Thyroid dysfunction was observed in 6 patients (54.55%), one of whom (9.09%) also exhibited pancreatic endocrine dysfunction. The average follow-up duration was 36.5 months. Eight patients (72.73%) were alive at the last follow-up. None of the patients recovered their pituitary hormone function. ConclusionsEndocrine adverse events induced by ICIs can involve multiple glandular systems. Clinicians should be highly vigilant for the possibility of ICI-induced hypophysitis in patients receiving ICIs who present with symptoms such as fatigue, anorexia, and hyponatremia.https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20250397immune checkpoint inhibitorimmune-related adverse eventhypophysitisclinical characteristic |
| spellingShingle | Zhixiao WANG Yun SHI Min SUN Xuqin ZHENG Tao YANG Min SHEN Analysis of the clinical characteristics of immune checkpoint inhibitor-related hypophysitis Zhongguo Linchuang Yixue immune checkpoint inhibitor immune-related adverse event hypophysitis clinical characteristic |
| title | Analysis of the clinical characteristics of immune checkpoint inhibitor-related hypophysitis |
| title_full | Analysis of the clinical characteristics of immune checkpoint inhibitor-related hypophysitis |
| title_fullStr | Analysis of the clinical characteristics of immune checkpoint inhibitor-related hypophysitis |
| title_full_unstemmed | Analysis of the clinical characteristics of immune checkpoint inhibitor-related hypophysitis |
| title_short | Analysis of the clinical characteristics of immune checkpoint inhibitor-related hypophysitis |
| title_sort | analysis of the clinical characteristics of immune checkpoint inhibitor related hypophysitis |
| topic | immune checkpoint inhibitor immune-related adverse event hypophysitis clinical characteristic |
| url | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20250397 |
| work_keys_str_mv | AT zhixiaowang analysisoftheclinicalcharacteristicsofimmunecheckpointinhibitorrelatedhypophysitis AT yunshi analysisoftheclinicalcharacteristicsofimmunecheckpointinhibitorrelatedhypophysitis AT minsun analysisoftheclinicalcharacteristicsofimmunecheckpointinhibitorrelatedhypophysitis AT xuqinzheng analysisoftheclinicalcharacteristicsofimmunecheckpointinhibitorrelatedhypophysitis AT taoyang analysisoftheclinicalcharacteristicsofimmunecheckpointinhibitorrelatedhypophysitis AT minshen analysisoftheclinicalcharacteristicsofimmunecheckpointinhibitorrelatedhypophysitis |