New Targets of Neuroprotection in Ischemic Stroke
Ischemic stroke represents one of the most challenging diseases in translational neurology. Despite the considerable efforts made to develop efficacious therapies that prevent damage once a stroke has occurred, there are still no established treatments for humans. The only available treatment is int...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2008.94 |
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| _version_ | 1832554641555980288 |
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| author | Marco Bacigaluppi Dirk M. Hermann |
| author_facet | Marco Bacigaluppi Dirk M. Hermann |
| author_sort | Marco Bacigaluppi |
| collection | DOAJ |
| description | Ischemic stroke represents one of the most challenging diseases in translational neurology. Despite the considerable efforts made to develop efficacious therapies that prevent damage once a stroke has occurred, there are still no established treatments for humans. The only available treatment is intravenous or intra-arterial thrombolysis that is limited to the very first hours after the stroke. Starting with recent findings about the pathophysiology of stroke and presenting an overview on current experimental models of this clinically highly relevant neurological disease, this paper will provide an overview on existing and emerging treatment concepts in ischemic stroke. Thus, our review will present an analysis of established and innovative strategies of neuroprotection and neurorestoration, highlighting both pharmacological and cell-based treatment concepts. In the last section of our paper, we will examine more closely how experimental data are presently translated to humans, with particular emphasis on the bioaccumulation and efficacy of drugs. From this point of view, we will try to develop ideas of how causative treatments in ischemic stroke may be established. |
| format | Article |
| id | doaj-art-77acd8a7cdfa469fb5209456cdbb02c7 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-77acd8a7cdfa469fb5209456cdbb02c72025-02-03T05:50:57ZengWileyThe Scientific World Journal1537-744X2008-01-01869871210.1100/tsw.2008.94New Targets of Neuroprotection in Ischemic StrokeMarco Bacigaluppi0Dirk M. Hermann1Department of Neurology, University Hospital Zurich (USZ), CH-8091 Zurich, SwitzerlandDepartment of Neurology, University Hospital Zurich (USZ), CH-8091 Zurich, SwitzerlandIschemic stroke represents one of the most challenging diseases in translational neurology. Despite the considerable efforts made to develop efficacious therapies that prevent damage once a stroke has occurred, there are still no established treatments for humans. The only available treatment is intravenous or intra-arterial thrombolysis that is limited to the very first hours after the stroke. Starting with recent findings about the pathophysiology of stroke and presenting an overview on current experimental models of this clinically highly relevant neurological disease, this paper will provide an overview on existing and emerging treatment concepts in ischemic stroke. Thus, our review will present an analysis of established and innovative strategies of neuroprotection and neurorestoration, highlighting both pharmacological and cell-based treatment concepts. In the last section of our paper, we will examine more closely how experimental data are presently translated to humans, with particular emphasis on the bioaccumulation and efficacy of drugs. From this point of view, we will try to develop ideas of how causative treatments in ischemic stroke may be established.http://dx.doi.org/10.1100/tsw.2008.94 |
| spellingShingle | Marco Bacigaluppi Dirk M. Hermann New Targets of Neuroprotection in Ischemic Stroke The Scientific World Journal |
| title | New Targets of Neuroprotection in Ischemic Stroke |
| title_full | New Targets of Neuroprotection in Ischemic Stroke |
| title_fullStr | New Targets of Neuroprotection in Ischemic Stroke |
| title_full_unstemmed | New Targets of Neuroprotection in Ischemic Stroke |
| title_short | New Targets of Neuroprotection in Ischemic Stroke |
| title_sort | new targets of neuroprotection in ischemic stroke |
| url | http://dx.doi.org/10.1100/tsw.2008.94 |
| work_keys_str_mv | AT marcobacigaluppi newtargetsofneuroprotectioninischemicstroke AT dirkmhermann newtargetsofneuroprotectioninischemicstroke |