Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing
The pathological microenvironment in diabetic wounds is delineated by heightened inflammatory responses and persistent proinflammatory macrophage activity, which significantly hinders the wound healing process. Exogenous electrical stimulation (ES), by modulating the electric field distribution in w...
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KeAi Communications Co., Ltd.
2025-05-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25000246 |
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| author | Zhiqing Liu Tianlong Wang Jinhui Zhao Lei Zhang Yiping Luo Yixing Chen Xinhui Wu Yaqi Liu Aihemaitijiang Aierken Dilixiati Duolikun Hui Jiang Xinyu Zhao Chang Li Yingchuan Li Wentao Cao Jianzhong Du Longpo Zheng |
| author_facet | Zhiqing Liu Tianlong Wang Jinhui Zhao Lei Zhang Yiping Luo Yixing Chen Xinhui Wu Yaqi Liu Aihemaitijiang Aierken Dilixiati Duolikun Hui Jiang Xinyu Zhao Chang Li Yingchuan Li Wentao Cao Jianzhong Du Longpo Zheng |
| author_sort | Zhiqing Liu |
| collection | DOAJ |
| description | The pathological microenvironment in diabetic wounds is delineated by heightened inflammatory responses and persistent proinflammatory macrophage activity, which significantly hinders the wound healing process. Exogenous electrical stimulation (ES), by modulating the electric field distribution in wounds, has shown significant potential in treating inflammatory wounds. However, this approach relies on additional power sources and complex circuit designs. Here, a bionic neuro-immuno-regulatory (BNIR) system was proposed for reshaping the endogenous electric fields (EFs) through collecting ion flow. The BNIR system comprises microporous structure scaffolds and nanosheets, enabling swift biofluid collection and electrical signal transmission, with the ability to promote cell proliferation and migration and exhibit antioxidant properties. More importantly, the BNIR system induced the transition of M1 macrophages to M2 macrophages through neuro-immuno-regulatory. In diabetic rat skin wounds, the BNIR system significantly enhanced healing by simultaneously neuro-immuno-regulatory, promoting angiogenesis, scavenging ROS, and facilitating tissue remodeling. This work aims to advance the development of a bionic system for electrosensitive tissue repair. |
| format | Article |
| id | doaj-art-77aa55c46c8b49d58f53298cca57375f |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-77aa55c46c8b49d58f53298cca57375f2025-01-26T05:04:27ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-05-0147266282Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healingZhiqing Liu0Tianlong Wang1Jinhui Zhao2Lei Zhang3Yiping Luo4Yixing Chen5Xinhui Wu6Yaqi Liu7Aihemaitijiang Aierken8Dilixiati Duolikun9Hui Jiang10Xinyu Zhao11Chang Li12Yingchuan Li13Wentao Cao14Jianzhong Du15Longpo Zheng16Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, ChinaDepartment of Critical Care Medicine, School of Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China; Corresponding author. 301 Middle Yanchang Road, Jing'an District, Shanghai, 200072, China.Department of Prosthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 201102, China; Corresponding authors. 166 Hechuan Road, Minhang District, Shanghai, 201100, China.Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai, 201804, China; School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China; Corresponding author. 301 Middle Yanchang Road, Jing'an District, Shanghai, 200072, China.Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Shanghai Trauma Emergency Center, Shanghai, 200072, China; Orthopedic Intelligent Minimally Invasive Diagnosis & Treatment Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Corresponding authors. 301 Middle Yanchang Road, Jing'an District, Shanghai, 200072, China.The pathological microenvironment in diabetic wounds is delineated by heightened inflammatory responses and persistent proinflammatory macrophage activity, which significantly hinders the wound healing process. Exogenous electrical stimulation (ES), by modulating the electric field distribution in wounds, has shown significant potential in treating inflammatory wounds. However, this approach relies on additional power sources and complex circuit designs. Here, a bionic neuro-immuno-regulatory (BNIR) system was proposed for reshaping the endogenous electric fields (EFs) through collecting ion flow. The BNIR system comprises microporous structure scaffolds and nanosheets, enabling swift biofluid collection and electrical signal transmission, with the ability to promote cell proliferation and migration and exhibit antioxidant properties. More importantly, the BNIR system induced the transition of M1 macrophages to M2 macrophages through neuro-immuno-regulatory. In diabetic rat skin wounds, the BNIR system significantly enhanced healing by simultaneously neuro-immuno-regulatory, promoting angiogenesis, scavenging ROS, and facilitating tissue remodeling. This work aims to advance the development of a bionic system for electrosensitive tissue repair.http://www.sciencedirect.com/science/article/pii/S2452199X25000246Conductive scaffoldWound exudate managementEndogenous electric fieldNeuro-immuno-regulatoryDiabetic wound healing |
| spellingShingle | Zhiqing Liu Tianlong Wang Jinhui Zhao Lei Zhang Yiping Luo Yixing Chen Xinhui Wu Yaqi Liu Aihemaitijiang Aierken Dilixiati Duolikun Hui Jiang Xinyu Zhao Chang Li Yingchuan Li Wentao Cao Jianzhong Du Longpo Zheng Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing Bioactive Materials Conductive scaffold Wound exudate management Endogenous electric field Neuro-immuno-regulatory Diabetic wound healing |
| title | Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing |
| title_full | Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing |
| title_fullStr | Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing |
| title_full_unstemmed | Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing |
| title_short | Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing |
| title_sort | endogenous electric field driven neuro immuno regulatory scaffold for effective diabetic wound healing |
| topic | Conductive scaffold Wound exudate management Endogenous electric field Neuro-immuno-regulatory Diabetic wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25000246 |
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