Physicochemical Characteristics of Chitosan–Alginate Scaffold Containing Atorvastatin
In addition to being a lipid-lowering medication, atorvastatin (ATV) is an anti-inflammatory agent. When there is a bone defect or inflammation of adjacent tissues, it aids in bone repair. This study aimed to develop a chitosan–alginate (CS/ALG)–tripolyphosphate (TPP)–ATV hybrid hydrogel as a drug d...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Advances in Polymer Technology |
| Online Access: | http://dx.doi.org/10.1155/2023/9452164 |
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| author | Hananeh Hamedfar Tayebeh Zivari-Ghader Abolfazl Akbarzadeh Soodabeh Davaran |
| author_facet | Hananeh Hamedfar Tayebeh Zivari-Ghader Abolfazl Akbarzadeh Soodabeh Davaran |
| author_sort | Hananeh Hamedfar |
| collection | DOAJ |
| description | In addition to being a lipid-lowering medication, atorvastatin (ATV) is an anti-inflammatory agent. When there is a bone defect or inflammation of adjacent tissues, it aids in bone repair. This study aimed to develop a chitosan–alginate (CS/ALG)–tripolyphosphate (TPP)–ATV hybrid hydrogel as a drug delivery system, using a tissue engineering scaffold for the first time. For this purpose, a CS/ALG hydrogel crosslinked with TPP was developed. The delivery profile of ATV and its physicochemical properties such as particle size and hydrogel swelling percentage were determined. The structure and morphology of the hydrogels were analyzed using Fourier transform infrared spectroscopy and scanning electron microscopy. As a result, an alginate–chitosan hydrogel with a TPP crosslinker was prepared. The results revealed that drug loading was nearly complete, and the first hour revealed a 25% explosive release. The drug was gradually released over 10 hr at approximately 35%. The amount of crosslinker used significantly influenced the encapsulation gain and release profiles. Owing to its high porosity and swelling, the CS/ALG hydrogel crosslinked with PPT is an ideal scaffold for loading drugs, macromolecules, and cells. |
| format | Article |
| id | doaj-art-779da38643f44d958c677c77c112bd53 |
| institution | Kabale University |
| issn | 1098-2329 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Polymer Technology |
| spelling | doaj-art-779da38643f44d958c677c77c112bd532025-02-03T06:42:53ZengWileyAdvances in Polymer Technology1098-23292023-01-01202310.1155/2023/9452164Physicochemical Characteristics of Chitosan–Alginate Scaffold Containing AtorvastatinHananeh Hamedfar0Tayebeh Zivari-Ghader1Abolfazl Akbarzadeh2Soodabeh Davaran3Department of Medicinal Chemistry, Faculty of PharmacyDepartment of Medicinal Chemistry, Faculty of PharmacyFaculty of Pharmacy, Department of Medicinal Chemistry and Drug Applied Research CenterDepartment of Medicinal Chemistry, Faculty of PharmacyIn addition to being a lipid-lowering medication, atorvastatin (ATV) is an anti-inflammatory agent. When there is a bone defect or inflammation of adjacent tissues, it aids in bone repair. This study aimed to develop a chitosan–alginate (CS/ALG)–tripolyphosphate (TPP)–ATV hybrid hydrogel as a drug delivery system, using a tissue engineering scaffold for the first time. For this purpose, a CS/ALG hydrogel crosslinked with TPP was developed. The delivery profile of ATV and its physicochemical properties such as particle size and hydrogel swelling percentage were determined. The structure and morphology of the hydrogels were analyzed using Fourier transform infrared spectroscopy and scanning electron microscopy. As a result, an alginate–chitosan hydrogel with a TPP crosslinker was prepared. The results revealed that drug loading was nearly complete, and the first hour revealed a 25% explosive release. The drug was gradually released over 10 hr at approximately 35%. The amount of crosslinker used significantly influenced the encapsulation gain and release profiles. Owing to its high porosity and swelling, the CS/ALG hydrogel crosslinked with PPT is an ideal scaffold for loading drugs, macromolecules, and cells.http://dx.doi.org/10.1155/2023/9452164 |
| spellingShingle | Hananeh Hamedfar Tayebeh Zivari-Ghader Abolfazl Akbarzadeh Soodabeh Davaran Physicochemical Characteristics of Chitosan–Alginate Scaffold Containing Atorvastatin Advances in Polymer Technology |
| title | Physicochemical Characteristics of Chitosan–Alginate Scaffold Containing Atorvastatin |
| title_full | Physicochemical Characteristics of Chitosan–Alginate Scaffold Containing Atorvastatin |
| title_fullStr | Physicochemical Characteristics of Chitosan–Alginate Scaffold Containing Atorvastatin |
| title_full_unstemmed | Physicochemical Characteristics of Chitosan–Alginate Scaffold Containing Atorvastatin |
| title_short | Physicochemical Characteristics of Chitosan–Alginate Scaffold Containing Atorvastatin |
| title_sort | physicochemical characteristics of chitosan alginate scaffold containing atorvastatin |
| url | http://dx.doi.org/10.1155/2023/9452164 |
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