Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine
Hepatic epithelioid hemangioendothelioma (HEH) is extremely rare, occurring in 1 to 2 per 100,000, with chemotherapy options not well defined. Our case involved a 49-year-old female who had hepatic masses and metastasis to the lungs with a liver biopsy revealing HEH. After developing a rash from sor...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/326795 |
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| author | Matthew P. Soape Rashmi Verma J. Drew Payne Mitchell Wachtel Fred Hardwicke Everardo Cobos |
| author_facet | Matthew P. Soape Rashmi Verma J. Drew Payne Mitchell Wachtel Fred Hardwicke Everardo Cobos |
| author_sort | Matthew P. Soape |
| collection | DOAJ |
| description | Hepatic epithelioid hemangioendothelioma (HEH) is extremely rare, occurring in 1 to 2 per 100,000, with chemotherapy options not well defined. Our case involved a 49-year-old female who had hepatic masses and metastasis to the lungs with a liver biopsy revealing HEH. After developing a rash from sorafenib, thalidomide was started with the progression of disease stabilized. Resection is only an option in 10% of the cases; therefore, chemotherapy is the only line of treatment. Newer chemotherapy alternatives are targeting angiogenesis via the vascular endothelial growth factor. Thalidomide was first used as an antiemetic, but, sadly, soon linked to phocomelia birth defects. Given the mechanism of action against angiogenesis, thalidomide has a valid role in vascular tumors. In conclusion, the use of thalidomide as chemotherapy is novel and promising, especially in the setting of a rare vascular liver tumor such as HEH. |
| format | Article |
| id | doaj-art-779d2ba851a84f5cb3234a1f476d92d4 |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-779d2ba851a84f5cb3234a1f476d92d42025-08-20T03:35:37ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362015-01-01201510.1155/2015/326795326795Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of MedicineMatthew P. Soape0Rashmi Verma1J. Drew Payne2Mitchell Wachtel3Fred Hardwicke4Everardo Cobos5Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USATexas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USATexas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USATexas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USATexas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USATexas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USAHepatic epithelioid hemangioendothelioma (HEH) is extremely rare, occurring in 1 to 2 per 100,000, with chemotherapy options not well defined. Our case involved a 49-year-old female who had hepatic masses and metastasis to the lungs with a liver biopsy revealing HEH. After developing a rash from sorafenib, thalidomide was started with the progression of disease stabilized. Resection is only an option in 10% of the cases; therefore, chemotherapy is the only line of treatment. Newer chemotherapy alternatives are targeting angiogenesis via the vascular endothelial growth factor. Thalidomide was first used as an antiemetic, but, sadly, soon linked to phocomelia birth defects. Given the mechanism of action against angiogenesis, thalidomide has a valid role in vascular tumors. In conclusion, the use of thalidomide as chemotherapy is novel and promising, especially in the setting of a rare vascular liver tumor such as HEH.http://dx.doi.org/10.1155/2015/326795 |
| spellingShingle | Matthew P. Soape Rashmi Verma J. Drew Payne Mitchell Wachtel Fred Hardwicke Everardo Cobos Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine Case Reports in Gastrointestinal Medicine |
| title | Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine |
| title_full | Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine |
| title_fullStr | Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine |
| title_full_unstemmed | Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine |
| title_short | Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine |
| title_sort | treatment of hepatic epithelioid hemangioendothelioma finding uses for thalidomide in a new era of medicine |
| url | http://dx.doi.org/10.1155/2015/326795 |
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