Immunocompatibility of Bacteriophages as Nanomedicines
Bacteriophage-based medical research provides the opportunity to develop targeted nanomedicines with heightened efficiency and safety profiles. Filamentous phages also can and have been formulated as targeted drug-delivery nanomedicines, and phage may also serve as promising alternatives/complements...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/2012/247427 |
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| _version_ | 1832567236795039744 |
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| author | Tranum Kaur Nafiseh Nafissi Olla Wasfi Katlyn Sheldon Shawn Wettig Roderick Slavcev |
| author_facet | Tranum Kaur Nafiseh Nafissi Olla Wasfi Katlyn Sheldon Shawn Wettig Roderick Slavcev |
| author_sort | Tranum Kaur |
| collection | DOAJ |
| description | Bacteriophage-based medical research provides the opportunity to develop targeted nanomedicines with heightened efficiency and safety profiles. Filamentous phages also can and have been formulated as targeted drug-delivery nanomedicines, and phage may also serve as promising alternatives/complements to antibiotics. Over the past decade the use of phage for both the prophylaxis and the treatment of bacterial infection, has gained special significance in view of a dramatic rise in the prevalence of antibiotic resistance bacterial strains. Two potential medical applications of phages are the treatment of bacterial infections and their use as immunizing agents in diagnosis and monitoring patients with immunodeficiencies. Recently, phages have been employed as gene-delivery vectors (phage nanomedicine), for nearly half a century as tools in genetic research, for about two decades as tools for the discovery of specific target-binding proteins and peptides, and for almost a decade as tools for vaccine development. As phage applications to human therapeutic development grow at an exponential rate, it will become essential to evaluate host immune responses to initial and repetitive challenges by therapeutic phage in order to develop phage therapies that offer suitable utility. This paper examines and discusses phage nanomedicine applications and the immunomodulatory effects of bacteriophage exposure and treatment modalities. |
| format | Article |
| id | doaj-art-7798cb39ef1445e8ad92b2c20d71cbec |
| institution | Kabale University |
| issn | 1687-9503 1687-9511 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-7798cb39ef1445e8ad92b2c20d71cbec2025-02-03T01:02:03ZengWileyJournal of Nanotechnology1687-95031687-95112012-01-01201210.1155/2012/247427247427Immunocompatibility of Bacteriophages as NanomedicinesTranum Kaur0Nafiseh Nafissi1Olla Wasfi2Katlyn Sheldon3Shawn Wettig4Roderick Slavcev5School of Pharmacy, University of Waterloo, Health Sciences Campus, 10 Victoria Street South, Kitchener, ON, N2L 3C4, CanadaSchool of Pharmacy, University of Waterloo, Health Sciences Campus, 10 Victoria Street South, Kitchener, ON, N2L 3C4, CanadaSchool of Pharmacy, University of Waterloo, Health Sciences Campus, 10 Victoria Street South, Kitchener, ON, N2L 3C4, CanadaSchool of Pharmacy, University of Waterloo, Health Sciences Campus, 10 Victoria Street South, Kitchener, ON, N2L 3C4, CanadaSchool of Pharmacy, University of Waterloo, Health Sciences Campus, 10 Victoria Street South, Kitchener, ON, N2L 3C4, CanadaSchool of Pharmacy, University of Waterloo, Health Sciences Campus, 10 Victoria Street South, Kitchener, ON, N2L 3C4, CanadaBacteriophage-based medical research provides the opportunity to develop targeted nanomedicines with heightened efficiency and safety profiles. Filamentous phages also can and have been formulated as targeted drug-delivery nanomedicines, and phage may also serve as promising alternatives/complements to antibiotics. Over the past decade the use of phage for both the prophylaxis and the treatment of bacterial infection, has gained special significance in view of a dramatic rise in the prevalence of antibiotic resistance bacterial strains. Two potential medical applications of phages are the treatment of bacterial infections and their use as immunizing agents in diagnosis and monitoring patients with immunodeficiencies. Recently, phages have been employed as gene-delivery vectors (phage nanomedicine), for nearly half a century as tools in genetic research, for about two decades as tools for the discovery of specific target-binding proteins and peptides, and for almost a decade as tools for vaccine development. As phage applications to human therapeutic development grow at an exponential rate, it will become essential to evaluate host immune responses to initial and repetitive challenges by therapeutic phage in order to develop phage therapies that offer suitable utility. This paper examines and discusses phage nanomedicine applications and the immunomodulatory effects of bacteriophage exposure and treatment modalities.http://dx.doi.org/10.1155/2012/247427 |
| spellingShingle | Tranum Kaur Nafiseh Nafissi Olla Wasfi Katlyn Sheldon Shawn Wettig Roderick Slavcev Immunocompatibility of Bacteriophages as Nanomedicines Journal of Nanotechnology |
| title | Immunocompatibility of Bacteriophages as Nanomedicines |
| title_full | Immunocompatibility of Bacteriophages as Nanomedicines |
| title_fullStr | Immunocompatibility of Bacteriophages as Nanomedicines |
| title_full_unstemmed | Immunocompatibility of Bacteriophages as Nanomedicines |
| title_short | Immunocompatibility of Bacteriophages as Nanomedicines |
| title_sort | immunocompatibility of bacteriophages as nanomedicines |
| url | http://dx.doi.org/10.1155/2012/247427 |
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