Gut microbiota-derived butyrate enhances exercise-induced bone mineral density in humans
Bone Mineral Density (BMD) is one of the primary markers of bone health. Exercise provides constant mechanical stress to bone, which in turn increases BMD. Gut-bone axis is considered to play an important role in the regulation of exercise on bone. Also, the metabolites of gut microbiota (GM), espec...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Mechanobiology in Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949907025000129 |
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| author | Xiangya Dou Pengyu Fu Yuting Zhang Yiwen Zhang Kaiting Ning Baoqiang Yang Xuezhou Yang Yinbo Niu Dong-En Wang Huiyun Xu |
| author_facet | Xiangya Dou Pengyu Fu Yuting Zhang Yiwen Zhang Kaiting Ning Baoqiang Yang Xuezhou Yang Yinbo Niu Dong-En Wang Huiyun Xu |
| author_sort | Xiangya Dou |
| collection | DOAJ |
| description | Bone Mineral Density (BMD) is one of the primary markers of bone health. Exercise provides constant mechanical stress to bone, which in turn increases BMD. Gut-bone axis is considered to play an important role in the regulation of exercise on bone. Also, the metabolites of gut microbiota (GM), especially short-chain fatty acids (SCFAs), are thought to be involved in the progress. In this study, by analyzing serum and GM from humans with low and high BMD, we found that exercise indeed enhanced BMD, and butyrate secreted from GM was involved in the regulation. |
| format | Article |
| id | doaj-art-77926d0b4bfb40c582a373b010ebdb6c |
| institution | DOAJ |
| issn | 2949-9070 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Mechanobiology in Medicine |
| spelling | doaj-art-77926d0b4bfb40c582a373b010ebdb6c2025-08-20T03:22:09ZengElsevierMechanobiology in Medicine2949-90702025-06-013210012410.1016/j.mbm.2025.100124Gut microbiota-derived butyrate enhances exercise-induced bone mineral density in humansXiangya Dou0Pengyu Fu1Yuting Zhang2Yiwen Zhang3Kaiting Ning4Baoqiang Yang5Xuezhou Yang6Yinbo Niu7Dong-En Wang8Huiyun Xu9School of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaDepartment of Sports, Northwestern Polytechnical University, Xi’an, ChinaDepartment of Sports, Northwestern Polytechnical University, Xi’an, ChinaSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, ChinaSchool of Life Sciences, Northwestern Polytechnical University, Xi’an, China; Corresponding author.School of Life Sciences, Northwestern Polytechnical University, Xi’an, China; Corresponding author.Bone Mineral Density (BMD) is one of the primary markers of bone health. Exercise provides constant mechanical stress to bone, which in turn increases BMD. Gut-bone axis is considered to play an important role in the regulation of exercise on bone. Also, the metabolites of gut microbiota (GM), especially short-chain fatty acids (SCFAs), are thought to be involved in the progress. In this study, by analyzing serum and GM from humans with low and high BMD, we found that exercise indeed enhanced BMD, and butyrate secreted from GM was involved in the regulation.http://www.sciencedirect.com/science/article/pii/S2949907025000129BMDExerciseMechanical stimulusGut-bone axis |
| spellingShingle | Xiangya Dou Pengyu Fu Yuting Zhang Yiwen Zhang Kaiting Ning Baoqiang Yang Xuezhou Yang Yinbo Niu Dong-En Wang Huiyun Xu Gut microbiota-derived butyrate enhances exercise-induced bone mineral density in humans Mechanobiology in Medicine BMD Exercise Mechanical stimulus Gut-bone axis |
| title | Gut microbiota-derived butyrate enhances exercise-induced bone mineral density in humans |
| title_full | Gut microbiota-derived butyrate enhances exercise-induced bone mineral density in humans |
| title_fullStr | Gut microbiota-derived butyrate enhances exercise-induced bone mineral density in humans |
| title_full_unstemmed | Gut microbiota-derived butyrate enhances exercise-induced bone mineral density in humans |
| title_short | Gut microbiota-derived butyrate enhances exercise-induced bone mineral density in humans |
| title_sort | gut microbiota derived butyrate enhances exercise induced bone mineral density in humans |
| topic | BMD Exercise Mechanical stimulus Gut-bone axis |
| url | http://www.sciencedirect.com/science/article/pii/S2949907025000129 |
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