Fibrous dysplasia as a possible false-positive finding in 68Ga-labeled prostate-specific membrane antigen positron emission tomography/computed tomography study in the follow-up of prostate cancer
Positron emission tomography/computed tomography (PET/CT) using 68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA) has become an important tool in restaging patients with prostate cancer (PCa). Despite its high sensitivity and specificity, this method may produce false-positive findings, as...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-10-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_111_18 |
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| author | André Marcondes Braga Ribeiro Eduardo Nóbrega Pereira Lima Maurìcio Murce Rocha |
| author_facet | André Marcondes Braga Ribeiro Eduardo Nóbrega Pereira Lima Maurìcio Murce Rocha |
| author_sort | André Marcondes Braga Ribeiro |
| collection | DOAJ |
| description | Positron emission tomography/computed tomography (PET/CT) using 68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA) has become an important tool in restaging patients with prostate cancer (PCa). Despite its high sensitivity and specificity, this method may produce false-positive findings, as indicated by previous studies. This case report aims to warn nuclear medicine physicians, oncologists, and urologists about the possibility of false-positive findings using this imaging modality, especially when the detected site is unusual for bone metastasis. A 68-year-old man with PCa underwent restaging tests after presenting with increased prostate-specific antigen.68Ga-PSMA PET/CT imaging revealed abnormal uptake in the left humeral head, which anatomically corresponded to the intramedullary and cortical sclerotic area. A biopsy was performed, and the pathology showed a lesion consisting of hard bone tissue with a small focal spot of fibrous dysplasia. Diagnostic issues related to 68Ga-PSMA PET/CT imaging should be disseminated to help physicians make appropriate treatment choices for each patient. |
| format | Article |
| id | doaj-art-7790da46a632499890ae7b3f4e33f228 |
| institution | OA Journals |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-7790da46a632499890ae7b3f4e33f2282025-08-20T01:57:55ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122019-10-01180440941210.4103/wjnm.WJNM_111_18Fibrous dysplasia as a possible false-positive finding in 68Ga-labeled prostate-specific membrane antigen positron emission tomography/computed tomography study in the follow-up of prostate cancerAndré Marcondes Braga Ribeiro0Eduardo Nóbrega Pereira Lima1Maurìcio Murce Rocha2Department of Nuclear Medicine, A. C. Camargo Cancer Center, São Paulo, BrazilDepartment of Nuclear Medicine, A. C. Camargo Cancer Center, São Paulo, BrazilDepartment of Urology, A. C. Camargo Cancer Center, São Paulo, BrazilPositron emission tomography/computed tomography (PET/CT) using 68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA) has become an important tool in restaging patients with prostate cancer (PCa). Despite its high sensitivity and specificity, this method may produce false-positive findings, as indicated by previous studies. This case report aims to warn nuclear medicine physicians, oncologists, and urologists about the possibility of false-positive findings using this imaging modality, especially when the detected site is unusual for bone metastasis. A 68-year-old man with PCa underwent restaging tests after presenting with increased prostate-specific antigen.68Ga-PSMA PET/CT imaging revealed abnormal uptake in the left humeral head, which anatomically corresponded to the intramedullary and cortical sclerotic area. A biopsy was performed, and the pathology showed a lesion consisting of hard bone tissue with a small focal spot of fibrous dysplasia. Diagnostic issues related to 68Ga-PSMA PET/CT imaging should be disseminated to help physicians make appropriate treatment choices for each patient.http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_111_18 68ga-labeled prostate-specific membrane antigenbone metastasisfalse-positive resultfibrous dysplasiaprostate cancer |
| spellingShingle | André Marcondes Braga Ribeiro Eduardo Nóbrega Pereira Lima Maurìcio Murce Rocha Fibrous dysplasia as a possible false-positive finding in 68Ga-labeled prostate-specific membrane antigen positron emission tomography/computed tomography study in the follow-up of prostate cancer World Journal of Nuclear Medicine 68ga-labeled prostate-specific membrane antigen bone metastasis false-positive result fibrous dysplasia prostate cancer |
| title | Fibrous dysplasia as a possible false-positive finding in 68Ga-labeled prostate-specific membrane antigen positron emission tomography/computed tomography study in the follow-up of prostate cancer |
| title_full | Fibrous dysplasia as a possible false-positive finding in 68Ga-labeled prostate-specific membrane antigen positron emission tomography/computed tomography study in the follow-up of prostate cancer |
| title_fullStr | Fibrous dysplasia as a possible false-positive finding in 68Ga-labeled prostate-specific membrane antigen positron emission tomography/computed tomography study in the follow-up of prostate cancer |
| title_full_unstemmed | Fibrous dysplasia as a possible false-positive finding in 68Ga-labeled prostate-specific membrane antigen positron emission tomography/computed tomography study in the follow-up of prostate cancer |
| title_short | Fibrous dysplasia as a possible false-positive finding in 68Ga-labeled prostate-specific membrane antigen positron emission tomography/computed tomography study in the follow-up of prostate cancer |
| title_sort | fibrous dysplasia as a possible false positive finding in 68ga labeled prostate specific membrane antigen positron emission tomography computed tomography study in the follow up of prostate cancer |
| topic | 68ga-labeled prostate-specific membrane antigen bone metastasis false-positive result fibrous dysplasia prostate cancer |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_111_18 |
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