CD155 as a therapeutic target in alveolar echinococcosis: insights from an Echinococcus multilocularis infection mouse model

CD155 as a therapeutic target in alveolar echinococcosis: insights from an Echinococcus multilocularis infection mouse model

IntroductionAlveolar echinococcosis (AE) is a life-threatening zoonotic parasitic disease caused by the metacestode stage of Echinococcus multilocularis, characterized by granulomatous lesions and liver fibrosis. Immune exhaustion is the key mechanism by which E. multilocularis evades host immune re...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xue Zhang, Liang Li, Tao Sun, Ning Yang, Hui Liu, Jin Chu, Junlong Xue, Guodong Lü, Tuerganaili Aji, Xiaojuan Bi, Renyong Lin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Microbiology
Subjects:	Echinococcus multilocularis CD155 T-cell exhaustion alveolar echinococcosis metacestode vesicles
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2025.1624387/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Clinical confirmation of an infection with Echinococcus multilocularis (Mongolian genotype): first case report of human alveolar echinococcosis in Inner Mongolia, China
by: Xu Wang, et al.
Published: (2025-07-01)

Double Trouble on the Lower Leg—Unique Human Coinfection with <i>Echinococcus granulosus</i> and <i>Echinococcus multilocularis</i> Without Liver Involvement
by: David Beck, et al.
Published: (2025-04-01)

Alveolar and neotropical echinococcosis
by: S. B. Chuelov, et al.
Published: (2022-11-01)

EmsB Microsatellite Analysis of <i>Echinococcus multilocularis</i> Specimens Isolated from Belgian Patients with Alveolar Echinococcosis and from Animal Hosts
by: Sabrina Egrek, et al.
Published: (2025-06-01)

The genetic variation of mitochondrial sequences and pathological differences of Echinococcus multilocularis strains from different continents
by: Baoping Guo, et al.
Published: (2025-04-01)

Advances in Novel Diagnostic Techniques for Alveolar Echinococcosis
by: Huanhuan Liu, et al.
Published: (2025-02-01)

Alveolar Echinococcosis in 11-Month-Old Dog—Clinical Case
by: Zuzana Šufliarska, et al.
Published: (2025-05-01)

Comprehensive Survival Analysis of Alveolar Echinococcosis Patients, University Hospital Zurich, Zurich, Switzerland, 1973–2022
by: Ansgar Deibel, et al.
Published: (2025-05-01)

Evaluation of vascular invasion in hepatic alveolar echinococcosis using computed tomography: An observational study
by: Ilyar A. Baudinov, et al.
Published: (2025-03-01)

Retrospective multidisciplinary analysis of human alveolar echinococcosis in Hungary using spatial epidemiology approaches
by: Eszter Csulak, et al.
Published: (2024-12-01)

Investigation of the threonine metabolism of Echinococcus multilocularis: The threonine dehydrogenase as a potential drug target in alveolar echinococcosis
by: Marc Kaethner, et al.
Published: (2025-04-01)

Epidemiological and clinical characteristics of patients in the alveolar echinococcosis registry, France, 1982 to 2021
by: on behalf of the FrancEchino network
Published: (2025-08-01)

Induced hepatocyte-like cells derived from adipose-derived stem cells alleviates liver injury in mice infected with Echinococcus Multilocularis
by: Hui Liu, et al.
Published: (2024-11-01)

Management of Echinococcus multilocularis in pregnancy: A case report
by: Zoe Fanning, et al.
Published: (2025-01-01)

Diagnostic imaging modalities in the study of hepatic alveolar echinococcosis: A review of literature
by: Iliar Baudinov, et al.
Published: (2025-04-01)

Efficacy of a novel chewable tablet (Credelio Quattro™) containing lotilaner, moxidectin, praziquantel, and pyrantel for the treatment and control of Echinococcus multilocularis and E. granulosus infections in dogs
by: Samuel Charles, et al.
Published: (2025-03-01)

A framework for predicting zoonotic hosts using pseudo-absences: the case of Echinococcus multilocularis
by: Andrea Simoncini, et al.
Published: (2025-12-01)

First detection of Echinococcus multilocularis in golden jackals (Canis aureus) in Bosnia and Herzegovina
by: Naida Kapo, et al.
Published: (2025-08-01)

Autochthonous human case of Echinococcus ortleppi cystic echinococcosis in Brittany, Western part of France
by: Brice Autier, et al.
Published: (2025-06-01)

Effects of maternal Echinococcus multilocularis infection on colitis susceptibility and gut microbiota of offspring
by: Yihui Liu, et al.
Published: (2025-07-01)

Annual assessment of Echinococcus multilocularis surveillance reports submitted in 2025 in the context of Commission Delegated Regulation (EU) 2018/772
by: European Food Safety Authority (EFSA), et al.
Published: (2025-07-01)

Annual assessment of Echinococcus multilocularis surveillance reports submitted in 2024 in the context of commission delegated regulation (EU) 2018/772
by: European Food Safety Authority (EFSA), et al.
Published: (2024-07-01)

IDO1 promotes Echinococcus multilocularis infection by regulating the formation of neutrophil extracellular traps
by: Haining Zhang, et al.
Published: (2025-07-01)

Typing of Echinococcus multilocularis by Region-Specific Extraction and Next-Generation Sequencing of the mitogenome
by: Franziska Rachel, et al.
Published: (2025-02-01)

Evaluation of karyopathic effects and general safety of <i>Trichinella spiralis</i> and <i>Echinococcus multilocularis</i> extracts in mice
by: E. I. Koveshnikova, et al.
Published: (2020-12-01)

Suitability of red fox (Vulpes vulpes) and golden jackal (Canis aureus) as hosts of Echinococcus multilocularis based on egg production characteristics and literature data on the intestinal ecosystems of carnivores
by: Sibusiso Moloi, et al.
Published: (2024-01-01)

Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis
by: Zhihua Ou, et al.
Published: (2025-05-01)

Blocking NKG2A in Echinococcus multilocularis infection partially relieves impairment of NK cell function of the host
by: Ayinuer Aierken, et al.
Published: (2025-08-01)

TIM4+macrophages suppress the proinflammatory response to maintain the chronic alveolar echinococcosis infection
by: Liang Wang, et al.
Published: (2025-06-01)

Echinococcosis of the liver in Poland – review of the literature and our own clinical material
by: Antonina Respondek, et al.
Published: (2024-07-01)

Multisystem involvement of alveolar echinococcosis in a child
by: Mecit Kantarci, et al.
Published: (2014-11-01)

<i>Echinococcus multilocularis</i> Calreticulin Inhibits Lectin Pathway of Complement Activation by Directly Binding to Mannose-Binding Lectin
by: Yuxiao Shao, et al.
Published: (2025-04-01)

Echinococcus granulosus promotes MAPK pathway-mediated osteoclast differentiation by inhibiting Nrf2 in osseous echinococcosis
by: Yaqing Liu, et al.
Published: (2025-04-01)

Surgical and cryosurgical treatment of recurrent liver Alveolar Echinococcosis
by: B. I. Alperovich, et al.
Published: (2005-12-01)

Preliminary Proteomic and Metabolomic Analyses Reveal Potential Serum Biomarkers for Identifying Alveolar Echinococcosis in Mice
by: Qing Zhang, et al.
Published: (2025-06-01)

Reemergence of Echinococcus granulosus Infections after 2004 Termination of Control Program in Magallanes Region, Chile
by: Cristian A. Alvarez Rojas, et al.
Published: (2025-02-01)

A case of alveolar echinococcosis in the liver that ruptured into the pericardium treated by a combination of hepatectomy and albendazole
by: Yoichi Yamamoto, et al.
Published: (2022-04-01)

Multimodal imaging for the diagnosis of cardiac alveolar echinococcosis: a case report
by: Mengdie Zhu, et al.
Published: (2025-02-01)

Seasonal population dynamics and dietary switching of Vulpes spp. amplify Echinococcus spp. transmission in the Eastern Tibetan plateau: implications for wildlife-mediated zoonotic risks
by: Xu Wang, et al.
Published: (2025-07-01)

Molecular Characterization of Echinococcus vogeli from Human Case, Colombia, 2024
by: Jorge Alfredo Morcillo Muñoz, et al.
Published: (2025-08-01)