A Case of Tumour Twins: A Rare Presentation of Simultaneous Breast and Endometrial Malignancies
The probability of simultaneous Breast Carcinoma (BC) and Endometrial Carcinoma (EC) in one person is extremely low and might be only a co-incidence. Hereby, the authors present a case report of a 62-year-old female presented to the Outpatient Department (OPD) with complaints of postmenopausal bleed...
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JCDR Research and Publications Private Limited
2024-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/20438/65747_CE[Ra1]_F(SHU)_QC(SD_IS)_PF1_(VD_OM)_PFA(IS)_PB(VD_IS)_PN(IS).pdf |
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| author | Sreenidhi Sreeram Barathi Gunabooshanam Vasugi Gramani Arumugam Gouthaman |
| author_facet | Sreenidhi Sreeram Barathi Gunabooshanam Vasugi Gramani Arumugam Gouthaman |
| author_sort | Sreenidhi Sreeram |
| collection | DOAJ |
| description | The probability of simultaneous Breast Carcinoma (BC) and Endometrial Carcinoma (EC) in one person is extremely low and might be only a co-incidence. Hereby, the authors present a case report of a 62-year-old female presented to the Outpatient Department (OPD) with complaints of postmenopausal bleeding for a period of six months. On examination, her abdomen was enlarged, and a right breast mass was also noted incidentally. An ultrasound of the abdomen showed a thickened endometrium. A screening mammogram revealed a Breast Imaging-Reporting and Data System (BI-RADS) 4B lesion in the lower central quadrant of the right breast. Subsequently, an endometrial aspiration was done and showed features of atypical endometrial hyperplasia. A Tru-cut biopsy of the right breast mass was taken, showed features of a mucinous neoplasm favouring mucinous carcinoma, Nottingham’s histological grade 1. Immunohistochemistry (IHC) work-up favoured a Luminal A molecular subtype of mammary carcinoma. Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) imaging were also done which revealed a thickened endometrium with increased metabolic activity. Patient underwent a right Modified Radical Mastectomy (MRM), total abdominal hysterectomy with bilateral salpingo-oophorectomy, and lymph node sampling. Grossly, the MRM specimen showed a single, grey-white, firm, infiltrative lesion measuring 2.2×2.2×1.5 cm in the lower central quadrant. Microscopy showed a neoplastic tissue composed of nests of tumour cells floating in lakes of abundant extracellular mucin. The hysterectomy specimen revealed a grey-white to grey-brown endometrial polyp measuring 3.5×2.5 cm, which microscopically showed tumour cells arranged in sheets and in a glandular and papillary pattern with fibrovascular core. IHC for microsatellite instability and p53 were done. |
| format | Article |
| id | doaj-art-7789870bbb3540909ff9c54de99f4f1b |
| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-7789870bbb3540909ff9c54de99f4f1b2025-01-04T11:21:12ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2024-12-011812081110.7860/JCDR/2024/65747.20438A Case of Tumour Twins: A Rare Presentation of Simultaneous Breast and Endometrial MalignanciesSreenidhi Sreeram0Barathi Gunabooshanam1Vasugi Gramani Arumugam2Gouthaman3Postgraduate, Department of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.Associate Professor, Department of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.Associate Professor, Department of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.Professor, Department of Surgical Oncology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.The probability of simultaneous Breast Carcinoma (BC) and Endometrial Carcinoma (EC) in one person is extremely low and might be only a co-incidence. Hereby, the authors present a case report of a 62-year-old female presented to the Outpatient Department (OPD) with complaints of postmenopausal bleeding for a period of six months. On examination, her abdomen was enlarged, and a right breast mass was also noted incidentally. An ultrasound of the abdomen showed a thickened endometrium. A screening mammogram revealed a Breast Imaging-Reporting and Data System (BI-RADS) 4B lesion in the lower central quadrant of the right breast. Subsequently, an endometrial aspiration was done and showed features of atypical endometrial hyperplasia. A Tru-cut biopsy of the right breast mass was taken, showed features of a mucinous neoplasm favouring mucinous carcinoma, Nottingham’s histological grade 1. Immunohistochemistry (IHC) work-up favoured a Luminal A molecular subtype of mammary carcinoma. Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) imaging were also done which revealed a thickened endometrium with increased metabolic activity. Patient underwent a right Modified Radical Mastectomy (MRM), total abdominal hysterectomy with bilateral salpingo-oophorectomy, and lymph node sampling. Grossly, the MRM specimen showed a single, grey-white, firm, infiltrative lesion measuring 2.2×2.2×1.5 cm in the lower central quadrant. Microscopy showed a neoplastic tissue composed of nests of tumour cells floating in lakes of abundant extracellular mucin. The hysterectomy specimen revealed a grey-white to grey-brown endometrial polyp measuring 3.5×2.5 cm, which microscopically showed tumour cells arranged in sheets and in a glandular and papillary pattern with fibrovascular core. IHC for microsatellite instability and p53 were done.https://www.jcdr.net/articles/PDF/20438/65747_CE[Ra1]_F(SHU)_QC(SD_IS)_PF1_(VD_OM)_PFA(IS)_PB(VD_IS)_PN(IS).pdfmicrosatellite instabilitymucinous neoplasmpapillary |
| spellingShingle | Sreenidhi Sreeram Barathi Gunabooshanam Vasugi Gramani Arumugam Gouthaman A Case of Tumour Twins: A Rare Presentation of Simultaneous Breast and Endometrial Malignancies Journal of Clinical and Diagnostic Research microsatellite instability mucinous neoplasm papillary |
| title | A Case of Tumour Twins: A Rare Presentation of Simultaneous Breast and Endometrial Malignancies |
| title_full | A Case of Tumour Twins: A Rare Presentation of Simultaneous Breast and Endometrial Malignancies |
| title_fullStr | A Case of Tumour Twins: A Rare Presentation of Simultaneous Breast and Endometrial Malignancies |
| title_full_unstemmed | A Case of Tumour Twins: A Rare Presentation of Simultaneous Breast and Endometrial Malignancies |
| title_short | A Case of Tumour Twins: A Rare Presentation of Simultaneous Breast and Endometrial Malignancies |
| title_sort | case of tumour twins a rare presentation of simultaneous breast and endometrial malignancies |
| topic | microsatellite instability mucinous neoplasm papillary |
| url | https://www.jcdr.net/articles/PDF/20438/65747_CE[Ra1]_F(SHU)_QC(SD_IS)_PF1_(VD_OM)_PFA(IS)_PB(VD_IS)_PN(IS).pdf |
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