PIAS4 regulates pluripotency exit and cell fate commitment in porcine embryonic stem cells

PIAS4 regulates pluripotency exit and cell fate commitment in porcine embryonic stem cells

Post-translational modifications (PTMs) are dynamic processes that regulate cell states by enhancing proteome diversity. However, the overall impact of PTMs on pluripotency exit in porcine embryonic stem cells (pESCs) remains largely unknown. Here, we present a systematic assay to identify E3 ubiqui...

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Bibliographic Details
Main Authors: Wei Qin, Yu Wang, Hongfei Duan, Qiao Li, Dagang Tao, Peng Su, Linhui Wu, Delong Li, Tian Xu, Shengsong Xie, Xia Zhang, Jilong Zhou, Yi-Liang Miao
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2025-07-01
Series:Fundamental Research
Subjects:
Pluripotency exit
porcine Extended Potential Stem Cells
PIAS4
CRISPR screening
Post-transcriptional modification
Ubiquitin ligase
Online Access:http://www.sciencedirect.com/science/article/pii/S2667325824004473
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